GB2200115B - Novel peptide derivatives, their production and use - Google Patents
Novel peptide derivatives, their production and useInfo
- Publication number
- GB2200115B GB2200115B GB8801040A GB8801040A GB2200115B GB 2200115 B GB2200115 B GB 2200115B GB 8801040 A GB8801040 A GB 8801040A GB 8801040 A GB8801040 A GB 8801040A GB 2200115 B GB2200115 B GB 2200115B
- Authority
- GB
- United Kingdom
- Prior art keywords
- production
- peptide derivatives
- novel peptide
- novel
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3701526 | 1987-01-21 | ||
DE3707339 | 1987-03-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8801040D0 GB8801040D0 (en) | 1988-02-17 |
GB2200115A GB2200115A (en) | 1988-07-27 |
GB2200115B true GB2200115B (en) | 1990-11-14 |
Family
ID=25851692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8801040A Expired - Lifetime GB2200115B (en) | 1987-01-21 | 1988-01-18 | Novel peptide derivatives, their production and use |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS6419053A (da) |
KR (1) | KR880009041A (da) |
AU (1) | AU1037588A (da) |
BE (1) | BE1002212A5 (da) |
CH (1) | CH676988A5 (da) |
DK (1) | DK22588A (da) |
FR (1) | FR2609716A1 (da) |
GB (1) | GB2200115B (da) |
IL (1) | IL85136A0 (da) |
IT (1) | IT1219811B (da) |
MY (1) | MY102311A (da) |
NL (1) | NL8800100A (da) |
SE (1) | SE8800169L (da) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6538006B1 (en) | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
USRE43596E1 (en) | 1992-08-25 | 2012-08-21 | G.D. Searle Llc | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
DE3732971A1 (de) * | 1987-09-30 | 1989-04-20 | Hoechst Ag | Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
DE3733296A1 (de) * | 1987-10-02 | 1989-04-20 | Merck Patent Gmbh | Aminosaeurederivate |
EP0397779A1 (en) * | 1988-02-01 | 1990-11-22 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
JP2524814B2 (ja) * | 1988-08-25 | 1996-08-14 | キッセイ薬品工業株式会社 | α―ヒドロキシ―β―アミノ酸の製造方法 |
CA2010531A1 (en) * | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
US5185284A (en) * | 1989-05-22 | 1993-02-09 | Mitsubishi Denki Kabushiki Kaisha | Method of making a semiconductor memory device |
US5098924A (en) * | 1989-09-15 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Diol sulfonamide and sulfinyl renin inhibitors |
TW225540B (da) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
DK0554400T3 (da) * | 1990-11-19 | 1998-02-16 | Monsanto Co | Retrovirale proteaseinhibitorer |
US5602175A (en) * | 1990-11-19 | 1997-02-11 | G.D. Searle & Co. | Retroviral protease inhibitors |
US5614522A (en) * | 1990-11-19 | 1997-03-25 | G.D. Searle & Co. | Retroviral protease inhibitors |
US5475013A (en) * | 1990-11-19 | 1995-12-12 | Monsanto Company | Retroviral protease inhibitors |
DK0731088T3 (da) | 1990-11-19 | 2000-10-16 | Monsanto Co | Retrovirale proteaseinhibitorer |
JPH06505963A (ja) * | 1990-11-19 | 1994-07-07 | モンサント カンパニー | レトロウイルスプロテアーゼ阻害剤 |
US5475027A (en) * | 1990-11-19 | 1995-12-12 | G.D. Searle & Co. | Retroviral protease inhibitors |
AU4253193A (en) * | 1992-05-20 | 1993-12-13 | G.D. Searle & Co. | Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors |
WO1993023379A1 (en) | 1992-05-21 | 1993-11-25 | Monsanto Company | Retroviral protease inhibitors |
EP0656888B1 (en) * | 1992-08-25 | 1998-01-07 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6743929B1 (en) | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
CA2142998C (en) * | 1992-08-25 | 2008-01-29 | Michael L. Vazquez | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors |
US6022994A (en) | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6046190A (en) * | 1992-08-25 | 2000-04-04 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
US5830897A (en) * | 1992-08-27 | 1998-11-03 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
CA2141570A1 (en) * | 1992-10-30 | 1994-05-11 | Michael L. Vazquez | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
US6337398B1 (en) | 1992-10-30 | 2002-01-08 | G.D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5756498A (en) * | 1992-10-30 | 1998-05-26 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
US5578606A (en) | 1992-10-30 | 1996-11-26 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
DE69319351T2 (de) | 1992-10-30 | 1998-11-19 | Monsanto Co | Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen |
AU5665194A (en) * | 1992-10-30 | 1994-05-24 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors |
US5514801A (en) | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
US5830888A (en) * | 1993-04-16 | 1998-11-03 | Monsanto Company | Macrocyclic retroviral protease inhibitors |
US5750648A (en) * | 1993-08-20 | 1998-05-12 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
US5602119A (en) * | 1993-10-29 | 1997-02-11 | Vazquez; Michael L. | Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
DK0749421T3 (da) * | 1994-03-07 | 2000-03-20 | Vertex Pharma | Sulfonamidderivater som aspartylproteaseinhibitorer |
EP1059285A3 (en) * | 1994-07-07 | 2001-10-31 | Pharm-Eco Laboratories, Inc. | Process for the preparation of 1,3-diamino-2-propanol and 1,3-diamino-2-propanone derivatives |
US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
AU693219B2 (en) * | 1994-07-07 | 1998-06-25 | Pharm-Eco Laboratories, Incorporated | Amino acid-derived diaminopropanols |
US5831117A (en) * | 1995-01-20 | 1998-11-03 | G. D. Searle & Co. | Method of preparing retroviral protease inhibitor intermediates |
US6143747A (en) | 1995-01-20 | 2000-11-07 | G. D. Searle & Co. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6140505A (en) | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
EP1188766A1 (en) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
JP4124818B2 (ja) | 1995-03-10 | 2008-07-23 | ジー.ディー.サール アンド カンパニー | ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター |
US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6407134B1 (en) | 1995-03-10 | 2002-06-18 | G. D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
US6063963A (en) * | 1995-07-05 | 2000-05-16 | Pharm-Eco Laboratories, Inc. | Amino acid-derived diaminopropanols |
AU7722296A (en) * | 1995-11-15 | 1997-06-05 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
JPH11324710A (ja) | 1998-05-20 | 1999-11-26 | Hitachi Ltd | ガスタービン発電プラント |
PT1086076E (pt) | 1998-06-19 | 2005-05-31 | Vertex Pharma | Inibidores de sulfonamida de aspartil protease |
US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
US7251926B2 (en) | 2001-07-26 | 2007-08-07 | Hitachi, Ltd. | Gas turbine installation |
JP3888095B2 (ja) | 2001-07-26 | 2007-02-28 | 株式会社日立製作所 | ガスタービン設備 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081783B1 (en) * | 1981-12-10 | 1985-06-19 | Merck & Co. Inc. | Renin inhibitory peptides having phe 13 deletion |
EP0152255A2 (en) * | 1984-02-03 | 1985-08-21 | Sankyo Company Limited | New renin-inhibitory peptides and their use |
EP0163237A2 (en) * | 1984-05-29 | 1985-12-04 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
EP0184550A2 (de) * | 1984-11-13 | 1986-06-11 | Ciba-Geigy Ag | 5-Amino-4-hydroxyvalerylamid-Derivate |
EP0184855A2 (en) * | 1984-12-14 | 1986-06-18 | Abbott Laboratories | Resin inhibiting compounds |
EP0228192A2 (en) * | 1985-11-29 | 1987-07-08 | Sankyo Company Limited | Renin-inhibitory oligopeptides, their preparation and use |
DE3601248A1 (de) * | 1986-01-17 | 1987-07-23 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4645759A (en) * | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
EP0486478A3 (en) * | 1984-08-06 | 1992-08-12 | The Upjohn Company | Renin-inhibiting peptides |
-
1988
- 1988-01-18 CH CH157/88A patent/CH676988A5/de not_active IP Right Cessation
- 1988-01-18 GB GB8801040A patent/GB2200115B/en not_active Expired - Lifetime
- 1988-01-18 NL NL8800100A patent/NL8800100A/nl not_active Application Discontinuation
- 1988-01-19 IL IL85136A patent/IL85136A0/xx unknown
- 1988-01-19 BE BE8800067A patent/BE1002212A5/fr not_active IP Right Cessation
- 1988-01-19 MY MYPI88000039A patent/MY102311A/en unknown
- 1988-01-19 AU AU10375/88A patent/AU1037588A/en not_active Abandoned
- 1988-01-19 FR FR8800636A patent/FR2609716A1/fr not_active Withdrawn
- 1988-01-19 DK DK022588A patent/DK22588A/da not_active Application Discontinuation
- 1988-01-20 SE SE8800169A patent/SE8800169L/xx not_active Application Discontinuation
- 1988-01-20 KR KR1019880000498A patent/KR880009041A/ko not_active Application Discontinuation
- 1988-01-20 JP JP63010571A patent/JPS6419053A/ja active Pending
- 1988-01-21 IT IT47556/88A patent/IT1219811B/it active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081783B1 (en) * | 1981-12-10 | 1985-06-19 | Merck & Co. Inc. | Renin inhibitory peptides having phe 13 deletion |
EP0152255A2 (en) * | 1984-02-03 | 1985-08-21 | Sankyo Company Limited | New renin-inhibitory peptides and their use |
EP0163237A2 (en) * | 1984-05-29 | 1985-12-04 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
EP0184550A2 (de) * | 1984-11-13 | 1986-06-11 | Ciba-Geigy Ag | 5-Amino-4-hydroxyvalerylamid-Derivate |
EP0184855A2 (en) * | 1984-12-14 | 1986-06-18 | Abbott Laboratories | Resin inhibiting compounds |
EP0228192A2 (en) * | 1985-11-29 | 1987-07-08 | Sankyo Company Limited | Renin-inhibitory oligopeptides, their preparation and use |
DE3601248A1 (de) * | 1986-01-17 | 1987-07-23 | Hoechst Ag | Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
Non-Patent Citations (3)
Title |
---|
Hypertension 8(6) Part 2 II-2 to II-5 (1986) * |
Struct. Funct. Proc. Am. Pept. Sym. 8th, ed. V. J. Hruby andD. H. Rich, pp. 511-20 ( * |
Tetrahedron Letters 24(41) 4401-4 (1983) * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE43596E1 (en) | 1992-08-25 | 2012-08-21 | G.D. Searle Llc | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
USRE43802E1 (en) | 1992-08-25 | 2012-11-13 | G.D. Searle Llc | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6538006B1 (en) | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
Also Published As
Publication number | Publication date |
---|---|
IT1219811B (it) | 1990-05-24 |
NL8800100A (nl) | 1988-08-16 |
KR880009041A (ko) | 1988-09-13 |
GB8801040D0 (en) | 1988-02-17 |
BE1002212A5 (fr) | 1990-10-16 |
IT8847556A0 (it) | 1988-01-21 |
JPS6419053A (en) | 1989-01-23 |
SE8800169D0 (sv) | 1988-01-20 |
DK22588D0 (da) | 1988-01-19 |
DK22588A (da) | 1988-07-22 |
MY102311A (en) | 1992-05-28 |
CH676988A5 (da) | 1991-03-28 |
AU1037588A (en) | 1988-09-01 |
FR2609716A1 (fr) | 1988-07-22 |
IL85136A0 (en) | 1988-06-30 |
SE8800169L (sv) | 1988-07-22 |
GB2200115A (en) | 1988-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |