GB2134791A - Antibacterial dressing - Google Patents

Antibacterial dressing Download PDF

Info

Publication number
GB2134791A
GB2134791A GB08403619A GB8403619A GB2134791A GB 2134791 A GB2134791 A GB 2134791A GB 08403619 A GB08403619 A GB 08403619A GB 8403619 A GB8403619 A GB 8403619A GB 2134791 A GB2134791 A GB 2134791A
Authority
GB
United Kingdom
Prior art keywords
moss
dressing
sphagnum
antibacterial
silver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08403619A
Other versions
GB2134791B (en
GB8403619D0 (en
Inventor
Dr Edmund Carus
John Tracey Scales
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernon Carus Ltd
Institute of Orthopaedics
Original Assignee
Vernon Carus Ltd
Institute of Orthopaedics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838303841A external-priority patent/GB8303841D0/en
Application filed by Vernon Carus Ltd, Institute of Orthopaedics filed Critical Vernon Carus Ltd
Priority to GB08403619A priority Critical patent/GB2134791B/en
Publication of GB8403619D0 publication Critical patent/GB8403619D0/en
Publication of GB2134791A publication Critical patent/GB2134791A/en
Application granted granted Critical
Publication of GB2134791B publication Critical patent/GB2134791B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

A surgical dressing comprises Sphagnum moss treated with an effective quantity of an antibacterial agent comprising for example, one or more of metallic silver, gold, palladium, platinum and tin. A silver/carbon composite may also be used.

Description

SPECIFICATION Antibacterial dressing This invention relates to an antibacterial surgical dressing.
Sphagnum moss possesses a unique structure with leaves which contain wide, elongated cells having perforated walls. These cells provide a very high liquid absorptive capacity for the moss. A leaf may retain 20 to 25 times its own weight of water. The elongate cells are interconnected by short stalks, which facilitate ingress of liquid by capillary action. The cells are strengthened by spiral rings of resilient material which make the leaves elastic, this being a vital property for use in surgical dressings. Moss is also effective in wound healing since blood constituents are transmitted to adjacent leaf cells. In addition there is a concentration of leucocytes and the interface between the moss and the wound.
According to the present invention an antibacterial dressing comprises sphagnum moss treated with an effective quantity of an antibacterial agent.
In comparison to artificial fibres, moss has a vast inherent surface area. Very effective impregnation of moss with antibacterial agents may be achieved with thorough dissemination of the agent.
Particularly preferred antibacterial agents may comprise metallic silver, gold, palladium, platinum and tin or mixtures or composites containing these metals. Silver/carbon complexes may also be used. These may be applied by vacuum deposition or by sputtering onto dried specimens of the moss. Silver is especially preferred, this metal having been found to release silver ions at a sufficiently slow rate to be effective without risk of harming the patient. The slow release is believed to be facilitated by a galvanic interaction with the moss or with added metallic or non-metallic compounds.
The moss may comprise one or more species selected from: Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum although alternative mosses may be used.
The moss is preferably crimped to break any large stalks prior to treatment with the bactericide. The moss may be mixed with other natural or man-made fibres to produce a composite dressing.
A discontinuous coating of metal has been found to be advantageous in that wound-healing properties of the moss are not inhibited.
The dressing has been found to be effective against both gram positive and gram negative bacteria.
The dressing may incorporate a membrane which is permeable to air and vapours but is impermeable to liquids.
Such a membrane facilitates oxygen transfer but does allow penetration of bacteria to the wound.
Claims
1. An antibacterial surgical dressing comprising Sphagnum moss treated with an effective quantity of an antibacterial agent.
2. A dressing as claimed in claim 1, wherein the antibacterial agent is selected from: metallic silver, gold, palladium, platinum or tin or mixtures thereof.
3. A dressing as claimed in claim 1 or 2, comprising a silver/carbon composite material.
4. A dressing as claimed in claim 2, wherein the agent is applied to dried moss by vacuum disposition or by sputtering.
5. A dressing as claimed in any preceding claim, wherein the moss comprises one or more species selected from Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum.
6. A dressing as claimed in any preceding claim, wherein the moss is crimped prior to treatment with the antibacterial agent.
7. A dressing as claimed in any preceding claim, further comprising a man made or natural fibre.
8. A dressing as claimed in any preceding claim, comprising a membrane which is permeable to air but impermeable to liquids.
9. A dressing substantially as hereinbefore described.
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (9)

**WARNING** start of CLMS field may overlap end of DESC **. SPECIFICATION Antibacterial dressing This invention relates to an antibacterial surgical dressing. Sphagnum moss possesses a unique structure with leaves which contain wide, elongated cells having perforated walls. These cells provide a very high liquid absorptive capacity for the moss. A leaf may retain 20 to 25 times its own weight of water. The elongate cells are interconnected by short stalks, which facilitate ingress of liquid by capillary action. The cells are strengthened by spiral rings of resilient material which make the leaves elastic, this being a vital property for use in surgical dressings. Moss is also effective in wound healing since blood constituents are transmitted to adjacent leaf cells. In addition there is a concentration of leucocytes and the interface between the moss and the wound. According to the present invention an antibacterial dressing comprises sphagnum moss treated with an effective quantity of an antibacterial agent. In comparison to artificial fibres, moss has a vast inherent surface area. Very effective impregnation of moss with antibacterial agents may be achieved with thorough dissemination of the agent. Particularly preferred antibacterial agents may comprise metallic silver, gold, palladium, platinum and tin or mixtures or composites containing these metals. Silver/carbon complexes may also be used. These may be applied by vacuum deposition or by sputtering onto dried specimens of the moss. Silver is especially preferred, this metal having been found to release silver ions at a sufficiently slow rate to be effective without risk of harming the patient. The slow release is believed to be facilitated by a galvanic interaction with the moss or with added metallic or non-metallic compounds. The moss may comprise one or more species selected from: Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum although alternative mosses may be used. The moss is preferably crimped to break any large stalks prior to treatment with the bactericide. The moss may be mixed with other natural or man-made fibres to produce a composite dressing. A discontinuous coating of metal has been found to be advantageous in that wound-healing properties of the moss are not inhibited. The dressing has been found to be effective against both gram positive and gram negative bacteria. The dressing may incorporate a membrane which is permeable to air and vapours but is impermeable to liquids. Such a membrane facilitates oxygen transfer but does allow penetration of bacteria to the wound. Claims
1. An antibacterial surgical dressing comprising Sphagnum moss treated with an effective quantity of an antibacterial agent.
2. A dressing as claimed in claim 1, wherein the antibacterial agent is selected from: metallic silver, gold, palladium, platinum or tin or mixtures thereof.
3. A dressing as claimed in claim 1 or 2, comprising a silver/carbon composite material.
4. A dressing as claimed in claim 2, wherein the agent is applied to dried moss by vacuum disposition or by sputtering.
5. A dressing as claimed in any preceding claim, wherein the moss comprises one or more species selected from Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum.
6. A dressing as claimed in any preceding claim, wherein the moss is crimped prior to treatment with the antibacterial agent.
7. A dressing as claimed in any preceding claim, further comprising a man made or natural fibre.
8. A dressing as claimed in any preceding claim, comprising a membrane which is permeable to air but impermeable to liquids.
9. A dressing substantially as hereinbefore described.
GB08403619A 1983-02-11 1984-02-10 Antibacterial dressing Expired GB2134791B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB08403619A GB2134791B (en) 1983-02-11 1984-02-10 Antibacterial dressing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838303841A GB8303841D0 (en) 1983-02-11 1983-02-11 Antibacterial dressing
GB08403619A GB2134791B (en) 1983-02-11 1984-02-10 Antibacterial dressing

Publications (3)

Publication Number Publication Date
GB8403619D0 GB8403619D0 (en) 1984-03-14
GB2134791A true GB2134791A (en) 1984-08-22
GB2134791B GB2134791B (en) 1987-05-20

Family

ID=26285208

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08403619A Expired GB2134791B (en) 1983-02-11 1984-02-10 Antibacterial dressing

Country Status (1)

Country Link
GB (1) GB2134791B (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255248A2 (en) * 1986-07-24 1988-02-03 Minnesota Mining And Manufacturing Company Antimicrobial wound dressing
DE4324994C1 (en) * 1993-07-26 1995-02-23 Demetron Gmbh Equipment and sanitary articles for hospitals
WO1995013704A1 (en) * 1993-11-18 1995-05-26 Westaim Technologies Inc. Anti-microbial materials
US5531726A (en) * 1993-09-21 1996-07-02 Johnson & Johnson, Inc. Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid
US5681575A (en) * 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US6017553A (en) * 1992-05-19 2000-01-25 Westaim Technologies, Inc. Anti-microbial materials
US6080490A (en) * 1990-12-24 2000-06-27 Westaim Technologies Inc. Actively sterile surfaces
US6365220B1 (en) 1997-11-03 2002-04-02 Nucryst Pharmaceuticals Corp. Process for production of actively sterile surfaces
US6897349B2 (en) 1997-11-14 2005-05-24 Acrymed Silver-containing compositions, devices and methods for making
WO2007077459A2 (en) * 2006-01-05 2007-07-12 Ntnu Technology Transfer As Moss-derived antimicrobial composition
EP1864634A3 (en) * 1997-09-22 2009-09-30 Argentum International, LLC Multilayer conductive appliance having wound healing and analgesic properties
US8192764B2 (en) 2006-01-13 2012-06-05 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
US8227365B2 (en) 2005-06-08 2012-07-24 Ramachandran Nageswaran Biocidal ceramic compositions, methods and articles of manufacture
US8293965B2 (en) 2006-04-28 2012-10-23 Kimberly-Clark Worldwide, Inc. Antimicrobial site dressings
US8361553B2 (en) 2004-07-30 2013-01-29 Kimberly-Clark Worldwide, Inc. Methods and compositions for metal nanoparticle treated surfaces
US8399027B2 (en) 2005-04-14 2013-03-19 3M Innovative Properties Company Silver coatings and methods of manufacture
US8486426B2 (en) 2002-07-29 2013-07-16 Kimberly-Clark Worldwide, Inc. Methods and compositions for treatment of dermal conditions
US8574610B2 (en) 2006-09-07 2013-11-05 Biolargo Life Technologies, Inc. Material having antimicrobial activity when wet
US8679523B2 (en) 1999-12-30 2014-03-25 Kimberly-Clark Worldwide, Inc. Oxygen-delivery closed cell foam matrix for wound treatment
US8900624B2 (en) 2004-07-30 2014-12-02 Kimberly-Clark Worldwide, Inc. Antimicrobial silver compositions
US9005449B2 (en) 2011-09-07 2015-04-14 Embro Corporation Use of moss to reduce disinfection by-products in water treated with disinfectants
US9289378B2 (en) 2004-09-20 2016-03-22 Avent, Inc. Antimicrobial amorphous compositions
US9795809B2 (en) 2013-12-23 2017-10-24 Embro Corporation Use of moss to improve dental health
US10251392B2 (en) 2004-07-30 2019-04-09 Avent, Inc. Antimicrobial devices and compositions

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861570B1 (en) 1997-09-22 2005-03-01 A. Bart Flick Multilayer conductive appliance having wound healing and analgesic properties
US8455710B2 (en) 1997-09-22 2013-06-04 Argentum Medical, Llc Conductive wound dressings and methods of use
US7214847B1 (en) 1997-09-22 2007-05-08 Argentum Medical, L.L.C. Multilayer conductive appliance having wound healing and analgesic properties
US5814094A (en) 1996-03-28 1998-09-29 Becker; Robert O. Iontopheretic system for stimulation of tissue healing and regeneration
US8801681B2 (en) 1995-09-05 2014-08-12 Argentum Medical, Llc Medical device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB422948A (en) * 1933-05-15 1935-01-22 Dozent Dr Fritz Feigl Method of producing therapeutically and disinfectantly active substances
GB474614A (en) * 1935-05-03 1937-11-02 Syngala Fabrik Fuer Chemisch S Method of producing therapeutically and disinfectantly active substances
GB863875A (en) * 1957-05-11 1961-03-29 Gustav Adolf Barth Improved metallized wound dressing
GB1270410A (en) * 1969-09-25 1972-04-12 Allor Corp Colloidal composition and method of preparing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB422948A (en) * 1933-05-15 1935-01-22 Dozent Dr Fritz Feigl Method of producing therapeutically and disinfectantly active substances
GB474614A (en) * 1935-05-03 1937-11-02 Syngala Fabrik Fuer Chemisch S Method of producing therapeutically and disinfectantly active substances
GB863875A (en) * 1957-05-11 1961-03-29 Gustav Adolf Barth Improved metallized wound dressing
GB1270410A (en) * 1969-09-25 1972-04-12 Allor Corp Colloidal composition and method of preparing the same

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728323A (en) * 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
EP0255248A3 (en) * 1986-07-24 1988-12-14 Minnesota Mining And Manufacturing Company Antimicrobial wound dressing
EP0255248A2 (en) * 1986-07-24 1988-02-03 Minnesota Mining And Manufacturing Company Antimicrobial wound dressing
US6080490A (en) * 1990-12-24 2000-06-27 Westaim Technologies Inc. Actively sterile surfaces
US5681575A (en) * 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US5770255A (en) * 1992-05-19 1998-06-23 Westaim Technologies, Inc. Anti-microbial coating for medical devices
US6017553A (en) * 1992-05-19 2000-01-25 Westaim Technologies, Inc. Anti-microbial materials
DE4324994C1 (en) * 1993-07-26 1995-02-23 Demetron Gmbh Equipment and sanitary articles for hospitals
US5531726A (en) * 1993-09-21 1996-07-02 Johnson & Johnson, Inc. Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid
WO1995013704A1 (en) * 1993-11-18 1995-05-26 Westaim Technologies Inc. Anti-microbial materials
EP1864634A3 (en) * 1997-09-22 2009-09-30 Argentum International, LLC Multilayer conductive appliance having wound healing and analgesic properties
US6365220B1 (en) 1997-11-03 2002-04-02 Nucryst Pharmaceuticals Corp. Process for production of actively sterile surfaces
US6897349B2 (en) 1997-11-14 2005-05-24 Acrymed Silver-containing compositions, devices and methods for making
US8203029B2 (en) 1997-11-14 2012-06-19 Kimberly-Clark Worldwide, Inc. Silver-containing compositions, devices and methods for making
US7576255B2 (en) 1997-11-14 2009-08-18 Acrymed, Inc. Silver-containing compositions, devices, and methods for making
US8679523B2 (en) 1999-12-30 2014-03-25 Kimberly-Clark Worldwide, Inc. Oxygen-delivery closed cell foam matrix for wound treatment
US9687503B2 (en) 1999-12-30 2017-06-27 Avent, Inc. Devices for delivering oxygen to the wounds
US8486426B2 (en) 2002-07-29 2013-07-16 Kimberly-Clark Worldwide, Inc. Methods and compositions for treatment of dermal conditions
US8361553B2 (en) 2004-07-30 2013-01-29 Kimberly-Clark Worldwide, Inc. Methods and compositions for metal nanoparticle treated surfaces
US8900624B2 (en) 2004-07-30 2014-12-02 Kimberly-Clark Worldwide, Inc. Antimicrobial silver compositions
US10251392B2 (en) 2004-07-30 2019-04-09 Avent, Inc. Antimicrobial devices and compositions
US9888691B2 (en) 2004-07-30 2018-02-13 Avent, Inc. Antimicrobial silver compositions
US9289378B2 (en) 2004-09-20 2016-03-22 Avent, Inc. Antimicrobial amorphous compositions
US8399027B2 (en) 2005-04-14 2013-03-19 3M Innovative Properties Company Silver coatings and methods of manufacture
US8227365B2 (en) 2005-06-08 2012-07-24 Ramachandran Nageswaran Biocidal ceramic compositions, methods and articles of manufacture
WO2007077459A2 (en) * 2006-01-05 2007-07-12 Ntnu Technology Transfer As Moss-derived antimicrobial composition
WO2007077459A3 (en) * 2006-01-05 2007-11-29 Ntnu Technology Transfer As Moss-derived antimicrobial composition
US8192764B2 (en) 2006-01-13 2012-06-05 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
US8293965B2 (en) 2006-04-28 2012-10-23 Kimberly-Clark Worldwide, Inc. Antimicrobial site dressings
US8574610B2 (en) 2006-09-07 2013-11-05 Biolargo Life Technologies, Inc. Material having antimicrobial activity when wet
US9005449B2 (en) 2011-09-07 2015-04-14 Embro Corporation Use of moss to reduce disinfection by-products in water treated with disinfectants
US9795809B2 (en) 2013-12-23 2017-10-24 Embro Corporation Use of moss to improve dental health

Also Published As

Publication number Publication date
GB2134791B (en) 1987-05-20
GB8403619D0 (en) 1984-03-14

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940210