GB2118172A - Preparation of a 2-alkyl-4- amino-5-aminomethylpyrimidine - Google Patents
Preparation of a 2-alkyl-4- amino-5-aminomethylpyrimidine Download PDFInfo
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- GB2118172A GB2118172A GB08302225A GB8302225A GB2118172A GB 2118172 A GB2118172 A GB 2118172A GB 08302225 A GB08302225 A GB 08302225A GB 8302225 A GB8302225 A GB 8302225A GB 2118172 A GB2118172 A GB 2118172A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Abstract
A process for the preparation of a 2-alkyl-4-amino-5-aminomethyl pyrimidine comprises subjecting a 2- alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst. The product is obtained in much higher yield than in known processes.
Description
SPECIFICATION
A process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine
This invention relates to a novel process for the preparation of a 2-alkyl-4-amino-5aminomethylpyrimidine.
It has been known that a 2-alkyl-4-amino-5-aminomethylpyrimidine is an important intermediate for the syntheses of Vitamin B1 and its analogues (Encyclopedia of Chemical Technology, Second
Edition, vol. 20, 173 (1969), John Wiley s Sons, Inc.).
As methods for preparing a 2-alkyl-4-amino-5-aminomethylpyrimidine, there have hitherto been known, for instance, a process in which a 2-alkyl-4-amino-5-cyanopyrimidine is reduced (Yakugaku
Zasshi (Journal of Pharmaceutics), Japan,73,977 (1953), J.A.C.S. 66 876 (1944)); a process in which a 2-alkyl-4-amino-5-acetamidomethylpyrimidine is hydrolyzed (Chem. Ber. 106 893 (1973)); and so on.
The present inventors have made earnest studies for the purpose of developing a novel process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine.
As the result, they have found that a 2-alkyl-4-amino-5-aminomethylpyrimidine may be prepared in much higher yield as compared with the processes known to the art, by subjecting a 2-alkyl-4amino-5-formylpyrimidine to reductive amination by catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst, and accomplished the present invention.
The starting material, i.e., the 2-alkyl-4-amino-5-formylpyrimidine used in the present invention, has the following structural formula:
wherein R includes a lower-alkyl group such as methyl, ethyl, propyl and butyl.
The starting material may easily be synthesized, for example, by hydrolyzing a 2-alkyl-4-amino-5dialkoxymethylpyridine in the presence of an acid. The starting 2-alkyl-4-amino-5-formylpyrimidine may also be employed in the form of a salt with a mineral acid such as sulfuric acid, nitric acid, hydrochloric acid, phosphoric acid and the like.
As the reduction catalyst used in the present process, there are useful a VIII group metal such as palladium, platinum, rhodium, ruthenium, nickel, cobalt and iron; and a metal such as copper and chromium. These metals are usually employed in the form of a metal per se. However, they may also be used in the form of a sait, an oxide or an alloy. Further, nickel may be in the form of a Raney-Nickel which has been developed according to an ordinary method known to the art. These catalysts may be employed alone or in admixture of two or more kinds thereof. Further, the catalyst may also be activated by, for example, hydrogen prior to the use thereof. Furthermore, these catalysts may also be employed after supported on a carrier such as an activated carbon, alumina, silica, silicon carbide, diatomaceous earth, pumice stone, zeolite, molecular sieves and the like.
The catalyst may typically be used in an amount of 0.001 to 3 gram atoms, preferably of 0.002 to 2 gram atoms in terms of the metal, per one mole of the starting 2-alkyl-4-amino-5-formylpyrimidine.
The hydrogen may typically be used in an amount of not less than one mole, preferably of 5 to 400 moles per one mole of the starting 2-alkyi-4-amino-5-formylpyrimidine. The ammonia may be used in the form of a liquid ammonia, an ammonia gas or an aqueous ammonia, in an amount of not less than one mole, preferably of 4 to 500 moles per one mole of the starting 2-alkyl-4-amino-5formylpyrimidine.
The reaction may be carried out in a solvent inert to the reaction. The solvents includes a lower aliphatic alcohol such as methanol, ethanol, propanol and butanol; an ether such as dioxane, tetrahydrofuran and diethyl ether; a hydrocarbon such as benzene, toluene, xylene, hexane and cyclohexane; and water.
The reaction is carried out at a temperature of O to 2000 C, preferably room temperature to 1200 C. While the reaction proceeds even under ambient pressure, it usually is carried out under a partial pressure of hydrogen of 1 to 100 Kg/cm2G since the reaction can proceed more speedily under positive pressure. For the reaction, a period of around 0.5 to 10 hours is sufficient.
According to a preferred embodiment of the present invention, the reduction reaction of the 2 alkyl4-am ino-5-formylpyrimidine is carried out in the presence of a salt of divalent nickel (Ni++) in addition to the reduction catalyst mentioned above.
As the salt of divalent nickel to be used in the present invention, there may be mentioned nickel chloride, nickel bromide, nickel sulfate, nickel nitrate, nickel phosphate, nickel carbonate, nickel hydroxide, nickel acetate, nickel oxalate, nickel benzoate, nickel ammonium chloride, nickel ammonium sulfate, nickel potassium sulfate and so on. These salts of divalent nickel may be employed alone or in combination of two or more kinds thereof. These divalent nickel salts may be used in the form of a hydrate (one which has a crystalline water). The amount of the salt to be used is in the range of 0.1 to 5 moles, preferably 0.4 to 1.0 mole per one mole of the starting 2-alkyl-4-amino-5-formylpyrimidine.If the amount is smaller than the lower limit of the above-mentioned range, it is not so expected that the suppression of the formation of such by-products as 2-alkyl-4-amino-5-hydroxymethylpyrimidine, di (2-alkyl-4-amino-5-pyrimidylmethyl)amine and the like will be effected. On the other hand, if the amount is larger than the upper limit of the above-mentioned range, the yield of the desired product is liable to be decreased.
As the reaction procedure, there may be carried out, for example, a process in which a 2-alkyl-4amino-5-formylpyrimidine is reacted with ammonia and hydrogen at the same time or a process in which a 2-alkyl-4-amino-5-formylpyrimidine is reacted first with ammonia followed by the reaction with hydrogen by introducing the same into the system, both in the presence of a salt of divalent nickel and a reduction catalyst. Further, the reaction may also be carried out by subjecting first a 2-alkyl-4amino-5-formylpyrimidine to reaction with ammonia in the presence of a salt of divalent nickel followed by the reaction with hydrogen while introducing the same into the system after addition of a reduction catalyst thereto.
According to another preferred embodiment of the present invention, the preparation of the 2alkyi-4-amino-5-aminomethylpyrimidine is carried out by subjecting the 2-alkyl-4-amino-5formylpyrimidine to reaction with ammonia in an inert solvent, adding the thus obtained reaction product, without isolating the same from the reaction mixture, to an inert solvent containing ammonia, hydrogen and the reduction catalyst mentioned above to reduce the reaction product mentioned above.
In the process according to the preferred embodiment, the 2-alkyl-4-amino-5-formylpyrimidine is reacted first with ammonia in an inert solvent.
The ammonia may be used in the form of a liquid ammonia, an ammonia gas or an aqueous ammonia, in an amount of not less than one mole preferably of 4 to 500 moles per one mole of the starting 2-alkyl-4-amino-5-formylpyrimidine.
The inert solvent may include the same as mentioned previously.
The amount of the solvent to be used may preferably be in the range of 3 to 30 parts by weight per one part by weight of the starting 2-alkyl-4-amino-5-formylpyrimidine.
The first reaction with ammonia is carried out at a temperature of O to 1300 C, preferably room temperature to 1 1 OOC. While the reaction proceeds under ambient pressure, it usually is carried out under a partial pressure of ammonia of 1 to 100 Kg/cm2G since the reaction can proceed mOre speedily under positive pressure. For the reaction, a period of around 0.5 to 10 hours is sufficient.
It may be supposed that the 2-alkyl-4-amino-5-formylpyrimidine has been converted, by the reaction, into an aldimine represented by the following general formula:
wherein R has the same meaning as defined above.
Next, the reaction mixture containing a reaction product which is supposed to be represented by the above general formula is added, optionally after removing the ammonia insoluble in the inert solvent, to an inert solvent containing ammonia, hydrogen and a reduction catalyst to reduce the reaction product mentioned above. The addition may be carried out by adding the reaction mixture containing the above-mentioned reaction product at one time. However, it usually is preferred to introduce it gradually and continuously over around 0.5 to 8 hours.
The catalyst may typically be used in the same amount as mentioned previously.
As the ammonia, a liquid ammonia, an ammonia gas and an aqueous ammonia may be used like they are used in the step of the reaction between the above-mentioned 2-alkyl-4-amino-5formylpyrimidine and ammonia. The amount thereof to be used is not less than one mole, preferably 4 to 300 moles per one mole of the starting 2-alkyl-4-amino-5-formylpyrimidine.
The hydrogen may typically be used in the same amount as mentioned previously.
The inert solvent used in this step of procedure may preferably be the same as used in the step of the reaction between the above-mentioned 2-alkyl-4-amino-5-formylpyrimidine and ammonia. The amount thereof to be used may preferably be in the range of 2 to 20 parts by weight per one part by weight of the starting 2-alkyl-4-amino-5-formylpyrimidine.
The reaction in this second step is carried out at a temperature of O to 2000 C, preferably room temperature to 1200 C. While the reaction may proceed under ambient pressure, it usually is carried out under a partial pressure of hydrogen of 1 to 100 Kg/cm2G. It may be sufficient to carry out the reaction for around 0.5 to 2 hours after addition of the reaction mixture containing the reaction product obtained from a 2-alkyl-4-amino-5-formylpyrimidine and ammonia.
The salt of diva lent nickel mentioned above may optionally be added to the reaction system of the above-mentioned first and/or second steps of the reaction, in order to enhance the yield of the desired product.
After completion of the reaction, the 2-alkyl-4-amino-5-aminomethylpyrimidine represented by the following general formula may be obtained in a free form or in the form of a salt with a mineral acid, for instance, by isolating it according to an ordinary method after cooling the reaction mixture and then removing the insolubles such as the catalyst by filtration.
wherein R has the same meaning as defined above.
Next, the Examples of the present invention will be described below. In each Example, the yield of the product is based on the 2-alkyl-4-amino-5-formylpyrimidine used as the starting material.
Example 1
In a 100 ml of an autoclave made of stainless steel were introduced 1.37 g (10 mmoles) of 2 methyl-4-amino-5-formylpyrimidine, 1 5 ml of methanol (solvent) and 0.5 g of a catalyst in which 5 wt % of palladium had been supported on an activated carbon, and the atmosphere within the system was replaced by nitrogen gas followed by addition thereto of 13.4 g of a liquid ammonia.
While stirring the contents, the temperature was raised and maintained at around 60"C for 1 hour. Thereafter, hydrogen gas was pressured thereinto at the same temperature so that the pressure might be around 40 Kg/cm2G, and the reaction was carried out at the same temperature for 3 hours.
After completion of the reaction, the reaction mixture was cooled and the unreacted ammonia gas and hydrogen gas are purged and released. Then the autoclave was opened and the catalyst was filtered off. Subsequently, a 1 N-HCI was added to the filtrate, and the mixture was adjusted to pH at around 3.
Then, the yields of the desired product, 2-methyl-4-amino-5-aminomethylpyrimidine and the byproduct, 2-methyl-4-amino-5-hydroxymethylpyrimidine were determined quantitatively as a dihydrochloride and a monohydrochloride, respectively, according to an internal standard method by way of liquid chromatography.
As the result, it was confirmed that the 2-methyl-4-amino-5-aminomethylpyrimidine and the 2 methyl-4-amino-5-hydroxymethylpyrimidine had been produced in yields of 90% and 5%, respectively.
Example 2
An experiment was run in the same manner as in Example 1 except that 1.51 g (10 mmoles) of 2ethyl-4-amino-5-formylpyrimidine was used as the starting material in place of the 2-methyl-4-amino5-formylpyrimidine and that 1 5 ml of ethanol was used as the solvent in place of the methanol.
As the result, it was found that 2-ethyl-4-amino-5-aminomethylpyrimidine had been produced in a yield of 91% and that 2-ethyl-4-amino-5-hydroxymethylpyrimidine had been by-produced in a yield of 4.5%.
Example 3
In a 100 ml of an autoclave made of stainless steel were introduced 1.37 g (10 mmoles) of 2 methyl-4-amino-5-formylpyrimidine, 1 5 ml of ethanol (solvent) and 1.0 g of Stabilized Nickel (trade name, Uni 03; manufactured by Nikki Kagaku Co., Ltd., nickel: around 50 wt % and diatomaceous earth: around 50 wt %). After the atmosphere within the system was replaced by nitrogen gas, 9.0 g of a liquid ammonia was added thereto. While stirring the contents, the temperature was raised and then maintained at around 900C for 30 minutes. Then, a hydrogen gas was pressured thereinto at the same temperature so that the pressure might be around 50 Kg/cm2G, and the reaction was carried out at the same temperature for 2 hours.
Treatment after completion of the reaction was carried out in the same manner as in Example 1.
As the result, it was confirmed that 2-methyl-4-amino-5-aminomethylpyrimidine and 2-methyl4-amino-5-hydroxymethylpyrimidine had been produced in yields of 89% and 5%, respectively.
Example 4
An experiment was run in the same manner as in Example 1 except that 1.0 g of a catalyst in which 5 wt % of platinum had been supported on alumina was used as the catalyst in place of the
Stabilized Nickel.
As the result, it was found that 2-methyl-4-amino-5-aminomethylpyrimidine and 2-methyl-4amino-5-hydroxymethylpyrimidine had been produced in yields of 87% and 6%, respectively.
Example 5
An experiment was run in the same manner as in Example 3, except that 1.0 g of a copperchromium powder was used as the catalyst in place of the Stabilized Nickel and that the pressure of the charged hydrogen gas was changed to be around 80 Kg/cm2G.
As the result, it was found that 2-methyl-4-amino-5-aminomethylpyrimidine had been produced in a yield of 77% and that 2-methyl-4-amino-5-hydroxymethylpyrimidine was by-produced in a yield of 20%.
Example 6
In a 100 ml of an autoclave made of stainless steel were introduced 1.74 g (10 mmoles) of 2methyl-4-amino-5-formylpyrimidine hydrochloride, 25 g of a 28 wt % aqueous ammonia and 1.0 g of a
Raney-Nickel (nickel content: around 40 wt %) which had been developed and washed with water (water: around 5 ml). After the atmosphere within the system was replaced by nitrogen gas, hydrogen gas was pressured thereinto so that the pressure might be around 40 Kg/cm2G. Subsequently, the temperature of the contents was raised with stirring, and the reaction was carried out at around 900C for 3 hours. After-treatment was conducted in the same manner as in Example 1.
As the result, it was found that 2-methyl-4-amino-5-aminomethylpyrimidine had been produced in a yield of 74% and that 2-methyl-4-amino-5-hydroxymethylpyrimidine was by-produced in a yield of 14%.
Example 7
In a 100 ml autoclave made of stainless steel, there were introduced 1.37 g (10 mmoles) of 2methyl-4-amino-5-formylpyrimidine, 30 ml of a 1 7 wt % methanolic solution of ammonia and a catalyst which had been prepared by developing 2.0 g of a Raney-Nickel (nickel content: around 40 wt %) followed by water-washing and replacement of the water with methanol (methanol: around 8 ml). Then, the temperature of the contents was raised with stirring, and the temperature was maintained at around 900C for 30 minutes. Thereafter, a hydrogen gas was pressured thereinto at the same temperature so that the pressure might be around 40 Kg/cm2G, and the reaction was carried out at the same temperature for 2 hours. Treatment after completion of the reaction was conducted in the same manner as in Example 1.
As the result, it was found that 2-methyl-4-amino-5-aminomethylpyrimidine and 2-methyl-4amino-5-hydroxymethylpyrimidine had been produced in yields of 85% and 4%, respectively.
Example 8
In a 100 ml autoclave made of stainless steel were introduced 1.37 g (10 mmoles) of 2-methyl 4-amino-5-formylpyrimidine, 24 g of a 20 wt % solution of ammonia in methanol and 0.74 g (5.7 mmoles) of anhydrous nickel chloride. After the atmosphere within the system was replaced by nitrogen gas, the temperature of the contents was raised with stirring and maintained at around 900C for one hour. After cooling, the autoclave was opened and 0.46 g of Stabilized Nickel (trade name,
N103B: manufactured by Nikki Kagaku Co., Ltd.; nickel: around 50 wt %, diatomaceous earth: around 50 wt %). After the atmosphere within the system was replaced by nitrogen gas, hydrogen gas was pressured thereinto so that the pressure might be around 30 Kg/cm2G.Then, the temperature of the content was raised with stirring and the reaction was carried out at around 900C for 2 hours.
After completion of the reaction, the reaction mixture was cooled and then unreacted gases etc.
were purged and released from the autoclave. Thereafter, the autoclave was opened and the catalyst was filtered off. After the washing obtained when the catalyst was washed with methanol was combined with the filtrate, the so combined liquid was concentrated under reduced pressure to remove major part of the ammonia. Then, a 1 N-HCI was added thereto to adjust the pH at around 3, and the mixture was subjected to liquid chromatography to determine respective reaction products quantitatively according to the internal standard method. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpydmidine 94.5%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.3%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 2.5%
Example 9
In a 100 ml autoclave made of stainless steel were introduced 1.37 g (10 mmoles) of 2-methyl 4-amino-5-formylpyrimidine, 24 g of a 20 wt % solution of ammonia in methanol, 0.74 g (5.7 mmoles)
of anhydrous nickel chloride and 0.46 g of Stabilized Nickel N103B. After the atmosphere within the
system was replaced by nitrogen gas, the temperature of the contents was raised with stirring and
maintained at around 900C for 30 minutes. Then, hydrogen gas was pressured thereinto at the same
temperature so that the pressure might be around 30 Kg/cm2G., and the reaction was carried out at the
same temperature followed by quantitative determination of the respective reaction products
according to the same procedure as in Example 8. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 93.8%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.5%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 2.5%
Example 10
An experiment was run in the same manner as in Example 9 except that the nickel chloride used in Example 9 was not employed.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 88.3%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 4.1%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amihe 5.8%
Example 11
In a 100 ml autoclave made of stainless steel, there were introduced 1.37 g (10 mmoles) of 2methyl-4-amino-5-formylpyrimidine, 24 g of a 20 wt % solution of ammonia in methanol and 1.34 g (5.4 mmoles) of nickel acetate tetrahydrate. After the atmosphere in the system was replaced by nitrogen gas, the temperature of the contents was raised with stirring and maintained at around 900C for one hour. After cooling, the autoclave was opened.Then, a catalyst which had been prepared by developing 2.0 g of a Raney-Nickel (nickel content: around 40 wt %) and washing with water followed by replacement of the water with methanol (methanol: around 6 ml) according to an ordinary method was introduced and the atmosphere in the system was replaced with nitrogen gas. Thereafter, hydrogen gas was pressured thereinto so that the pressure might be around 40 Kg/cm2G. Then, the temperature of the content was raised with stirring and the reaction was carried out with stirring at 900C for 2 hours. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 92.9%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.6%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 2.5%
Example 12
An experiment was run in the same manner as in Example 8 except that 0.75 g (5.3 mmoles in terms of the total nickel salts) of Nick, Ni(OH)2 4H2O was used in place of the nickel chloride in
Example 8. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimldine 93.4%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.4%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 2.9%
Example 13
An experiment was run in the same manner as in Example 8 except that 1.51 g (10 mmoles) of 2ethyl-4-amino-5-formylpyrimidine was used as the starting material in place of the 2-methyl-4-amino5-formylpyrimidine and 30 g of a 20 wt % solution of ammonia in ethanol was used in place of the 20 wt % solution of ammonia in methanol. The results are as follows.
Yield of 2-ethyl-4-amino-5-aminomethylpyrimidine 95.1% Yield of 2-ethyl-4-amino-5-hydroxymethylpyrimidine 1.5%
Yield of di-(2-ethyl-4-amino-5-pyrimidylmethyl)amine 2.0%
Example 14
In a 100 ml autoclave made of stainless steel, equipped with a high pressure feed pump, there were introduced 11 g of a 20 wt % solution of ammonia in methanol, 0.67 g of Stabilized Nickel (trade name, N1 03B; manufactured by Nikki Kagaku Co., Ltd.; nickel: around 50 wt %, diatomaceous earth: around 50 wt %) and hydrogen gas so that the pressure might be around 30 Kg/cm2G. The temperature of the mixture was raised with stirring and maintained at 1 100C.
In another 100 ml autoclave made of stainless steel, there were introduced 2 g (14.6 mmoles) of 2-methyl-4-amino-5-formylpyrimidine and 24 g of a 20 wt % solution of ammonia in methanol and then the mixture was subjected to reaction with stirring at 900C for 2 hours, followed by cooling and opening of the autoclave. The total amount of the thus obtained reaction mixture was pressured over two hours, by using the high pressure feed pump, into the previously prepared mixture which had been maintained at 11 00C, and the reaction was continued for 30 minutes at the same temperature.
After completion of the reaction, the autoclave was cooled and the unreacted gases and the like were purged and released from the autoclave. Then, the autoclave was opened and the catalyst therein was collected by filtration. Then, the washing which was obtained by washing the catalyst with methanol was combined with the filtrate and the so combined liquid was concentrated under reduced pressure to remove the ammonia. The pH value of the resultant residue was adjusted at around 3 with a 1 N-HCI and the respective reaction products were determined quantitatively by liquid chromatography according to the internal standard method. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 94.8%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.6%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 0.9%
Example 15
An experiment was carried out in the same manner as in Example 14 except tht the used amount of Stabilized Nickel N1 03B was changed to be 1.33 g; the used amount of 2-methyl-4-amino-5formylpyrimidine was changed to be 4 g (29.2 mmoles); and the period of time for continuous feeding under pressure by the use of the high pressure feed pump was changed to be 4 hours. The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 92.9%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 0.8%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 1.5%
Example 16
In a 100 ml autoclave made of stainless steel, equipped with a high pressure feed pump, there were introduced 10 g of a mixed solvent of methanol and dioxane (weight ratio,6:4),2 g of a liquid ammonia, 1.33 g of Stabilized Nickel N 103B and hydrogen gas so that the pressure might be 20
Kg/cm2G. Then, the temperature of the mixture was raised with stirring and maintained at 1 1 OOC.
On the other hand, in another 100 ml autoclave made of stainless steel, there were reacted 4 g (29.2 mmoles) of 2-methyl-4-amino-5-formylpyrimidine and 25 g of a liquid ammonia in 1 8 g of a mixed solvent of methanol and dioxane with stirring at 600C for 3 hours. After cooling, the autoclave was opened and the excess amount of ammonia was removed. Then, the total amount of the so obtained reaction mixture was introduced under pressure, by using the high pressure feed pump, into the previously prepared mixture which had been maintained at a temperature of 1 1 OOC, over 4 hours, and the reaction was continued at the same temperature for 30 minutes.
After completion of the reaction, treatment was carried out in the same manner as in Example 14.
The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 90.4%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 1.1% Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 1.8%
Example 17
In a 100 ml autoclave made of stainless steel, equipped with a high pressure feed pump, there were introduced 12 g of a 20 wt % solution of ammonia in methanol, 0.67 g of Stabilized Nickel N103B and hydrogen gas so that the pressure might be around 30 Kg/cm2G. Then, the temperature of the mixture was raised and maintained at 1000C with stirring.
On the other hand, in a 100 ml two-necked flask equipped with a gas-inlet tube having a glass filter and a reflux condenser having a silica-gel tube, there were introduced 4 g (29.2 mmoles) of 2methyl-4-amino-5-formylpyrimidine and 26 g of a 20 wt % solution of ammonia in methanol. While introducing an NH3 gas at a rate of 100 ml/min with stirring, the reaction was carried out at 400C for 10 hours followed by cooling. The total amount of the thus obtained reaction mixture was pressured over 4 hours, by the use of the high pressure feed pump, into the previously prepared mixture which had been maintained at 1000C, and the reaction was continued at the same temperature for 30 minutes.
After completion of the reaction, treatment was carried out in the same manner as in Example 14.
The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 90.5%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidine 1.1% Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 1.6%
Example 18
In a 100 ml autoclave made of stainless steel, equipped with a high pressure feed pump, there were introduced a catalyst which had been prepared by developing 2 g of a Raney-Nickel (nickel content: around 40 wt %) and washing with water according to an ordinary method followed by replacement of the water with methanol (methanol: around 12 g), 3 g of a liquid ammonia and hydrogen gas so that the pressure might be around 30 Kg/cm2G. Then, the temperature of the mixture was raised with stirring and maintained at 900 C.
On the other hand, in another 100 ml autoclave made of stainless steel, there were introduced 2 g (14.6 mmoles) of 2-methyl-4-amino-5-formylpyrimidine and 28 g of a 20 wt % solution of ammonia in methanol, and the reaction was carried out at 900C for 2 hours with stirring. After cooling, the autoclave was opened. Then, the total amount of the thus obtained reaction mixture was pressured over 2 hours, by using the high pressure feed pump, into the previously prepared mixture which had been maintained at 900C and the reaction was continued at the same temperature for 30 minutes.
After completion of the reaction, treatment was conducted in the same manner as in Example 14.
The results are as follows.
Yield of 2-methyl-4-amino-5-aminomethylpyrimidine 91.7%
Yield of 2-methyl-4-amino-5-hydroxymethylpyrimidirie 1.8%
Yield of di-(2-methyl-4-amino-5-pyrimidylmethyl)amine 1.2%
Claims (14)
1. A process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, characterized in that a 2-alkyl-4-amino-5-formylpyrimidine is subjected to catalystic reaction with hydrogen and ammonia in the presence of a reduction catalyst.
2. A process as claimed in Claim 1, wherein a salt of divalent nickel is incorporated in the reaction system in addition to the reduction catalyst.
3. A process as claimed in Claim 2, wherein the salt of divalent nickel is used in an amount of 0.1 to 5 moles per one mole of the 2-aikyl-4-amino-5-formylpyrimidine.
4. A process as claimed in Claim 1 or 2, which comprises subjecting the 2-alkyl-4-amino-5formylpyrimidine to reaction with ammonia in an inert solvent; adding the thus obtained reaction product, without isolating the same from the reaction mixture, to an inert solvent containing ammonia, hydrogen and the reduction catalyst to reduce said reaction product.
5. A process as claimed in Claim 1, 2 or 4, wherein the hydrogen is used in an amount of 5 to 400 moles per one mole of the 2-alkyl-4-amino-5-formylpyrimidine.
6. A process as claimed in Claim 1, 2 or 4, wherein the reduction catalyst contains a metal atom selected from the group consisting of palladium, rhodium, platinium, ruthenium, nickel, cobalt, iron, copper and chromium, and is used in an amount of 0.001 to 3 gram atoms in terms of the metal, per one mole of the 2-al kyl-4-amino- 5-formylpyrimidine.
7. A process as claimed in Claim 1 or 2, wherein the catalytic reaction is carried out at a temperature of 0 to 2000C.
8. A process as claimed in Claim 1 or 2, wherein the ammonia is used in the form of a liquid ammonia, an ammonia gas or an aqueous ammonia in an amount of 4 to 500 moles per one mole of the 2-al kyl-4-amino-5-formylpyrimidine.
9. A process as claimed in Claim 4, wherein the ammonia for the reaction with the 2-alkyl-4amino-5-formylpyrimidine is used in the form of a liquid ammonia, an ammonia gas or an aqueous ammonia, in an amount of 4 to 500 moles per one mole of the 2-alkyl-4-amino-5-formylpyrimidine.
10. A process as claimed in Claim 14, wherein the solvent for the reaction of the 2-alkyl-4amino-5-formylpyrimidine with ammonia is used in an amount of 3 to 30 parts by weight per one part by weight of the 2-alkyl-4-amino-5-formylpyrimidine.
11. A process as claimed in Claim 4, wherein the reaction of the 2-aikyl-4-amino-5- formylpyrimidine with ammonia is carried out at a temperature of 0 to 1 300C under a partial pressure of ammonia of 1 to 100 Kg/cm2G.
12. A process as claimed in Claim 1, 2 or 4, wherein the catalytic reaction is carried out at a temperature of 0 to 2000C.
13. A process as claimed in Claim 4, wherein the ammonia for the catalytic reaction is used in the form of a liquid ammonia, an ammonia gas or an aqueous ammonia in an amount of 4 to 300 moles per one mole of the 2-alkyl-4-amino-5-formylpyrimidine.
14. A process as claimed in Claim 4, wherein the solvent for the catalytic reaction is used in an amount of 2 to 20 parts by weight per one part by weight of the 2-alkyl-4-amino-5-formylpyrimidine.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1550382A JPS58134081A (en) | 1982-02-04 | 1982-02-04 | Preparation of 4-amino-5-dialkoxymethylpyrimidine derivative |
| JP2212282A JPS58140079A (en) | 1982-02-16 | 1982-02-16 | Preparation of 2-alkyl-4-amino-5-aminomethylpyrimidine |
| JP57154661A JPS5944364A (en) | 1982-09-07 | 1982-09-07 | Preparation of 2-lakyl-4-amino-5-aminomethylpyrimidine |
| JP15891682A JPS5948464A (en) | 1982-09-14 | 1982-09-14 | Preparation of 2-alkyl-4-amino-5-aminomethylpyrimidine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8302225D0 GB8302225D0 (en) | 1983-03-02 |
| GB2118172A true GB2118172A (en) | 1983-10-26 |
| GB2118172B GB2118172B (en) | 1985-11-27 |
Family
ID=27456393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08302225A Expired GB2118172B (en) | 1982-02-04 | 1983-01-27 | Preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH653023A5 (en) |
| DE (1) | DE3303789A1 (en) |
| GB (1) | GB2118172B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210394150A1 (en) * | 2021-04-01 | 2021-12-23 | Fudan University | Full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186928A (en) * | 1983-04-07 | 1984-10-23 | Ube Ind Ltd | Production of primary amine |
| CN109293580A (en) * | 2018-12-04 | 2019-02-01 | 南京金浩医药科技有限公司 | A kind of preparation process of 2- methyl -4- amino -5- aminomethyl pyrimidine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4152353A (en) * | 1977-08-29 | 1979-05-01 | The Dow Chemical Company | Method of producing amines from alcohols, aldehydes, ketones and mixtures thereof |
-
1983
- 1983-01-27 GB GB08302225A patent/GB2118172B/en not_active Expired
- 1983-02-03 CH CH61783A patent/CH653023A5/en not_active IP Right Cessation
- 1983-02-04 DE DE19833303789 patent/DE3303789A1/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210394150A1 (en) * | 2021-04-01 | 2021-12-23 | Fudan University | Full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine |
| US11554356B2 (en) * | 2021-04-01 | 2023-01-17 | Fudan University | Full continuous flow preparation method of 2-methyl-4-amino-5-aminomethylpyrimidine |
Also Published As
| Publication number | Publication date |
|---|---|
| CH653023A5 (en) | 1985-12-13 |
| GB2118172B (en) | 1985-11-27 |
| DE3303789A1 (en) | 1983-08-11 |
| DE3303789C2 (en) | 1988-08-18 |
| GB8302225D0 (en) | 1983-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19970127 |