GB2042887B - Albumin microaggregates for radioactive scanning of reticuloendothelial systems - Google Patents

Albumin microaggregates for radioactive scanning of reticuloendothelial systems

Info

Publication number
GB2042887B
GB2042887B GB7906298A GB7906298A GB2042887B GB 2042887 B GB2042887 B GB 2042887B GB 7906298 A GB7906298 A GB 7906298A GB 7906298 A GB7906298 A GB 7906298A GB 2042887 B GB2042887 B GB 2042887B
Authority
GB
United Kingdom
Prior art keywords
albumin
microaggregates
reticuloendothelial systems
radioactive scanning
reducing metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7906298A
Other versions
GB2042887A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
New England Nuclear Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Nuclear Corp filed Critical New England Nuclear Corp
Priority to GB7906298A priority Critical patent/GB2042887B/en
Priority to FR7905669A priority patent/FR2450611A1/en
Priority to NL7901767A priority patent/NL190050C/en
Priority to SE7902009A priority patent/SE431286B/en
Priority to DE19792909355 priority patent/DE2909355C2/en
Priority to JP3540079A priority patent/JPS55130921A/en
Publication of GB2042887A publication Critical patent/GB2042887A/en
Application granted granted Critical
Publication of GB2042887B publication Critical patent/GB2042887B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Micro aggregates of albumin wherein the albumin particles comprise a reducing metal e.g. tin bound thereto and also Tc-99 m radioactively labeled such microaggregates are useful for imaging of reticuloendothelial systems (RES), especially the liver, spleen and bone marrow. Compositions may also contain a stabilizing ligand for the reducing metal e.g. a phosphonate, phosphate, aminocarboxylate, polyhydroxycarboxylate or polycarboxylates.
GB7906298A 1979-02-22 1979-02-22 Albumin microaggregates for radioactive scanning of reticuloendothelial systems Expired GB2042887B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB7906298A GB2042887B (en) 1979-02-22 1979-02-22 Albumin microaggregates for radioactive scanning of reticuloendothelial systems
FR7905669A FR2450611A1 (en) 1979-02-22 1979-03-05 ALBUMIN MICRO-AGGREGATES FOR RADIOACTIVE EXPLORATION OF CROSS-ENDOTHELIAL SYSTEMS
NL7901767A NL190050C (en) 1979-02-22 1979-03-06 PREPARATION SUITABLE FOR USE, AFTER MARKING WITH TC-99M, AS A RADIO-DIAGNOSTIC AGENT.
SE7902009A SE431286B (en) 1979-02-22 1979-03-06 ALBUMIN MICROAGGER FOR RADIOACTIVE INVESTIGATION OF RETICULOENDOTELIAL SYSTEM AND SET FOR PRODUCING THEREOF
DE19792909355 DE2909355C2 (en) 1979-02-22 1979-03-09 Composition for the radioactive display of the reticulo-endothelial system, method for the preparation of the composition and a radiodiagnostic containing the composition
JP3540079A JPS55130921A (en) 1979-02-22 1979-03-26 Albumin microaggregate for radioactive scanning in reticuloendotissue system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7906298A GB2042887B (en) 1979-02-22 1979-02-22 Albumin microaggregates for radioactive scanning of reticuloendothelial systems

Publications (2)

Publication Number Publication Date
GB2042887A GB2042887A (en) 1980-10-01
GB2042887B true GB2042887B (en) 1983-10-12

Family

ID=10503365

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7906298A Expired GB2042887B (en) 1979-02-22 1979-02-22 Albumin microaggregates for radioactive scanning of reticuloendothelial systems

Country Status (6)

Country Link
JP (1) JPS55130921A (en)
DE (1) DE2909355C2 (en)
FR (1) FR2450611A1 (en)
GB (1) GB2042887B (en)
NL (1) NL190050C (en)
SE (1) SE431286B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410507A (en) 1981-08-28 1983-10-18 Solco Basel Ag Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310038D0 (en) * 1983-04-13 1983-05-18 Amersham Int Plc Technetium-99 labelled tin colloid
SE463651B (en) * 1983-12-21 1991-01-07 Nycomed As DIAGNOSTIC AND CONTRACTOR
SU1708350A1 (en) * 1988-04-15 1992-01-30 Оренбургский Государственный Медицинский Институт Bacillus subtilis strain as radionuclide carrier
ES2096521B1 (en) * 1994-08-10 1997-11-16 Univ La Laguna BIODEGRADABLE SYNTHETIC POLYMER MICROSPHERES IN THE MANUFACTURE AND ELABORATION OF REACTIVE EQUIPMENT FOR THE PREPARATION OF RADIOPHARMACEUTICAL MEDICINES.
EP1683517A1 (en) * 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
WO2011071155A1 (en) * 2009-12-10 2011-06-16 シスメックス株式会社 Method for detection of basic peptide and reagent for detection of basic peptide
US10556916B2 (en) * 2014-04-01 2020-02-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Zirconium-89 oxine complex as a cell labeling agent for positron emission tomography

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281134A1 (en) * 1974-08-06 1976-03-05 Commissariat Energie Atomique 99M TECHNETIUM MARKING PROCESS
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410507A (en) 1981-08-28 1983-10-18 Solco Basel Ag Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use

Also Published As

Publication number Publication date
JPS55130921A (en) 1980-10-11
NL7901767A (en) 1980-09-09
NL190050C (en) 1993-10-18
DE2909355A1 (en) 1980-09-11
GB2042887A (en) 1980-10-01
JPH0343254B2 (en) 1991-07-01
SE431286B (en) 1984-01-30
DE2909355C2 (en) 1985-09-12
FR2450611B1 (en) 1983-02-25
FR2450611A1 (en) 1980-10-03
NL190050B (en) 1993-05-17
SE7902009L (en) 1980-09-07

Similar Documents

Publication Publication Date Title
GB2042887B (en) Albumin microaggregates for radioactive scanning of reticuloendothelial systems
EP0661311A3 (en) Compound fine particles and compositions for forming film.
GB2306484B (en) Coded particles for process sequence tracking in combinatorial compound library preparation
DE3278081D1 (en) Method and apparatus for distributing powdered particles
TW239075B (en)
LTIP609A (en) Multinuclear complexes, contrast media containing them and use
EP0462554A3 (en) Charged particle beam apparatus
WO1991010645A3 (en) Chelants
AU5607880A (en) Iron alloy powder for electromagnetic applications
FR2507816B1 (en) FOCUSING DEFLECTION SYSTEM FOR LOADED PARTICLE BEAM
ZA858973B (en) Magnetic particles for diagnostics purposes
EP0678770A3 (en) Solid particle dispersions for imaging systems.
GB2147764B (en) Microscope for producing high resolution images without precision optics
PT971678E (en) COMPOSITE MATERIAL FOR DENTAL RECONSTITUTION AND METHOD OF RECONSTITUTION OF UMDENT
DE3163087D1 (en) Radioactive diagnostic agent for bone scanning and non-radioactive carrier therefor
DE69023885D1 (en) METHOD FOR COOLING A RAY OF CHARGED PARTICLES.
EP0439367A3 (en) Magnetic particles containing iron as the main component and process for producing the same
WO1997010852A3 (en) Xsns-type bi-functional sulphide-containing sulphonamide chelating agents for radioactive isotopes
WO1997010853A3 (en) N2s2-type bi-functional nicotinamide chelating agents for radioactive isotopes
HUT36157A (en) Composition suitable for polimerization
CA2082628A1 (en) Low-dust or dust-free dye preparations
MX9603001A (en) Oral magnetic particle formulation.
GB2052146B (en) Unitary electromagnet for double deflection scanning of charged particle beam
ZA851409B (en) Bis(aminomethyl)bicyclo(2.2.1)heptanes useful as metal ion control agents and radioactive metals complexed therewith
DE3063755D1 (en) Technetium-99m labeled acetanilidoiminodiacetates for liver function diagnosis and process for their preparation

Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950222