LTIP609A - Multinuclear complexes, contrast media containing them and use - Google Patents
Multinuclear complexes, contrast media containing them and useInfo
- Publication number
- LTIP609A LTIP609A LTIP609A LTIP609A LTIP609A LT IP609 A LTIP609 A LT IP609A LT IP609 A LTIP609 A LT IP609A LT IP609 A LTIP609 A LT IP609A LT IP609 A LTIP609 A LT IP609A
- Authority
- LT
- Lithuania
- Prior art keywords
- media containing
- contrast media
- complexes
- multinuclear complexes
- multinuclear
- Prior art date
Links
- 229940039231 contrast media Drugs 0.000 title 1
- 239000002872 contrast media Substances 0.000 title 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
- C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Liquid Crystal (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
- Steroid Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Lubricants (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Electric Propulsion And Braking For Vehicles (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to the use as contrast enhacing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W2O2( mu 2O)2, in which the complexed entity comprises at least two contrast enhancing atoms.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909006977A GB9006977D0 (en) | 1990-03-28 | 1990-03-28 | Compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP609A true LTIP609A (en) | 1994-12-27 |
LT3535B LT3535B (en) | 1995-11-27 |
Family
ID=10673438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP609A LT3535B (en) | 1990-03-28 | 1993-06-03 | Multinuclear complexes, contrast media containing them and use |
Country Status (18)
Country | Link |
---|---|
US (2) | US5458869A (en) |
EP (2) | EP0521977B1 (en) |
JP (1) | JPH06507147A (en) |
AT (1) | ATE142508T1 (en) |
AU (1) | AU645796B2 (en) |
CA (1) | CA2079212A1 (en) |
DE (1) | DE69122092T2 (en) |
DK (1) | DK0521977T3 (en) |
ES (1) | ES2091323T3 (en) |
FI (1) | FI924297A0 (en) |
GB (1) | GB9006977D0 (en) |
HK (1) | HK219596A (en) |
HU (2) | HU9203086D0 (en) |
LT (1) | LT3535B (en) |
LV (1) | LV10056B (en) |
NO (1) | NO923739L (en) |
SG (1) | SG43931A1 (en) |
WO (1) | WO1991014460A1 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992017215A1 (en) | 1990-03-28 | 1992-10-15 | Nycomed Salutar, Inc. | Contrast media |
GB9006977D0 (en) * | 1990-03-28 | 1990-05-23 | Nycomed As | Compositions |
NZ242156A (en) * | 1991-03-27 | 1994-07-26 | Salutar Inc | Diagnostic imaging reagent having at least two metal atoms and a non-metal bridging group |
US5330742A (en) * | 1991-08-05 | 1994-07-19 | Mallinckrodt Medical, Inc. | Methods and compositions for magnetic resonance imaging |
DE69231966T2 (en) * | 1991-08-05 | 2001-11-15 | Mallinckrodt Inc | HEAVY METAL CLUSTER FOR USE AS AN IMAGE |
US5364953A (en) * | 1992-11-05 | 1994-11-15 | Mallinckrodt Medical, Inc. | High relaxivity, paramagnetic, metal clusters for magnetic resonance imaging |
GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
US5717121A (en) * | 1995-06-07 | 1998-02-10 | Nycomed Salutar, Inc. | Preparation and use of contrast agents |
GB9601340D0 (en) * | 1996-01-23 | 1996-03-27 | Nycomed Salutar Inc | Contrast media |
WO1997030459A1 (en) * | 1996-02-14 | 1997-08-21 | Philips Electronics N.V. | X-ray examination apparatus with x-ray filter |
US5804161A (en) * | 1996-05-14 | 1998-09-08 | Nycomed Salutar Inc. | Contrast agents |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
WO2000035887A2 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6511648B2 (en) | 1998-12-18 | 2003-01-28 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6596259B1 (en) | 1998-12-22 | 2003-07-22 | University Of Puerto Rico | Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same |
US7807137B1 (en) | 1998-12-22 | 2010-10-05 | University Of Puerto Rico | Iron-based contrast agent |
US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
AU783857B2 (en) | 2000-06-01 | 2005-12-15 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a beta protein production |
US6770259B2 (en) | 2000-11-03 | 2004-08-03 | Bristol-Myers Squibb Pharma Company | Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation |
AU2002315208A1 (en) * | 2001-06-12 | 2002-12-23 | University Of Florida | Method and device for producing near-infrared radiation |
EP1423152A4 (en) | 2001-08-08 | 2006-12-27 | Bristol Myers Squibb Pharma Co | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US6838074B2 (en) | 2001-08-08 | 2005-01-04 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
US7485283B2 (en) | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
JP4322781B2 (en) * | 2004-11-08 | 2009-09-02 | 富士フイルム株式会社 | Imaging device |
US20070014721A1 (en) * | 2005-06-30 | 2007-01-18 | Harris Thomas D | Hydrazide conjugates as imaging agents |
US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
US20070098640A1 (en) * | 2005-11-02 | 2007-05-03 | General Electric Company | Nanoparticle-based imaging agents for X-ray/computed tomography |
US9149545B2 (en) * | 2005-11-02 | 2015-10-06 | General Electric Company | Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same |
US20070179094A1 (en) | 2006-01-31 | 2007-08-02 | Bayer Schering Pharma Ag | Modulation of MDL-1 activity for treatment of inflammatory disease |
CA2967254C (en) | 2008-02-29 | 2019-03-26 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including imaging cancer |
EP2296550B1 (en) * | 2008-07-07 | 2018-03-28 | Koninklijke Philips N.V. | K-edge imaging |
EP2419096B1 (en) | 2009-04-15 | 2019-11-13 | Lantheus Medical Imaging, Inc. | Stabilization of radiopharmaceutical compositions using ascorbic acid |
WO2011035140A1 (en) | 2009-09-18 | 2011-03-24 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of contrast moieties to the lungs |
SG10201500929XA (en) | 2010-02-08 | 2015-04-29 | Lantheus Medical Imaging Inc | Methods and apparatus for synthesizing imaging agents, and intermediates thereof |
EP2540321A1 (en) | 2011-06-30 | 2013-01-02 | Bayer Intellectual Property GmbH | Bis Tridentate W3O2 Clusters for X-Ray imaging |
AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
EP2733148A1 (en) | 2012-11-15 | 2014-05-21 | Bayer Pharma Aktiengesellschaft | Tungsten complexes with di-dentate ligands |
AU2014228815B2 (en) | 2013-03-15 | 2019-04-18 | The Regents Of The University Of California | Peptides having reduced toxicity that stimulate cholesterol efflux |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US468759A (en) | 1892-02-09 | Gabeiel a | ||
US3763188A (en) * | 1972-01-19 | 1973-10-02 | Du Pont | Spiro(1,1-polyethylenedi(oxymethyl))-3-oxetanes |
US3860611A (en) * | 1972-01-19 | 1975-01-14 | Du Pont | Macrocyclic polyether polyols and condensation polymers derived therefrom |
US3952015A (en) * | 1973-11-12 | 1976-04-20 | Carl George Krespan | Macrocyclic compounds having oxa and aza linkages in the ring and containing spirooxetane groups |
US4079124A (en) * | 1976-04-21 | 1978-03-14 | Medi-Physics, Inc. | Method of preparing X-ray contrast media containing ores of hafnium, tantalum and tungsten |
US4176173A (en) * | 1977-07-18 | 1979-11-27 | Medi-Physics, Inc. | Radiographic compositions |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4652519A (en) | 1983-02-03 | 1987-03-24 | Yeda Research And Development Company Limited | Bifunctional chelating agents and process for their production |
US4826673A (en) | 1985-01-09 | 1989-05-02 | Mallinckrodt, Inc. | Methods and compositions for enhancing magnetic resonance imaging |
CA1282069C (en) | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
IT1213029B (en) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | PARAMAGNETIC METAL ION CHELATES. |
DE3855239T2 (en) | 1987-07-16 | 1996-10-31 | Nycomed Imaging As | Aminocarboxylic acid and derivatives |
FR2630547A1 (en) * | 1988-04-22 | 1989-10-27 | Centre Nat Rech Scient | COLD MARKING OF MOLECULES OF PEPTIDE OR PROTEIN NATURE |
US5260050A (en) * | 1988-09-29 | 1993-11-09 | Ranney David F | Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes |
EP0361960A3 (en) * | 1988-09-29 | 1992-01-02 | RANNEY, David F. | Methods and compositions for magnetic resonance imaging |
GB9006977D0 (en) * | 1990-03-28 | 1990-05-23 | Nycomed As | Compositions |
US5186923A (en) * | 1990-10-10 | 1993-02-16 | Brigham And Womens Hospital | Enhancement of cellular accumulation of lipophilic cationic organometallic compounds by reduction of intramembrane potential |
DE69231966T2 (en) * | 1991-08-05 | 2001-11-15 | Mallinckrodt Inc | HEAVY METAL CLUSTER FOR USE AS AN IMAGE |
-
1990
- 1990-03-28 GB GB909006977A patent/GB9006977D0/en active Pending
-
1991
- 1991-03-27 US US07/927,484 patent/US5458869A/en not_active Expired - Fee Related
- 1991-03-27 DE DE69122092T patent/DE69122092T2/en not_active Expired - Fee Related
- 1991-03-27 WO PCT/EP1991/000587 patent/WO1991014460A1/en active IP Right Grant
- 1991-03-27 ES ES91906843T patent/ES2091323T3/en not_active Expired - Lifetime
- 1991-03-27 HU HU923086V patent/HU9203086D0/en unknown
- 1991-03-27 DK DK91906843.7T patent/DK0521977T3/en active
- 1991-03-27 SG SG1996005936A patent/SG43931A1/en unknown
- 1991-03-27 HU HU9203086A patent/HUT69168A/en unknown
- 1991-03-27 AU AU75578/91A patent/AU645796B2/en not_active Ceased
- 1991-03-27 JP JP3506810A patent/JPH06507147A/en active Pending
- 1991-03-27 EP EP91906843A patent/EP0521977B1/en not_active Expired - Lifetime
- 1991-03-27 AT AT91906843T patent/ATE142508T1/en not_active IP Right Cessation
- 1991-03-27 CA CA002079212A patent/CA2079212A1/en not_active Abandoned
- 1991-03-27 EP EP94203047A patent/EP0645146A1/en not_active Withdrawn
-
1992
- 1992-09-25 FI FI924297A patent/FI924297A0/en unknown
- 1992-09-25 NO NO92923739A patent/NO923739L/en unknown
- 1992-12-30 LV LVP-92-681A patent/LV10056B/en unknown
-
1993
- 1993-06-03 LT LTIP609A patent/LT3535B/en not_active IP Right Cessation
-
1994
- 1994-12-22 US US08/363,163 patent/US5614168A/en not_active Expired - Fee Related
-
1996
- 1996-12-24 HK HK219596A patent/HK219596A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
LV10056B (en) | 1995-02-20 |
US5614168A (en) | 1997-03-25 |
HU9203086D0 (en) | 1992-12-28 |
DE69122092T2 (en) | 1997-03-06 |
HK219596A (en) | 1997-01-03 |
LV10056A (en) | 1994-05-10 |
US5458869A (en) | 1995-10-17 |
ES2091323T3 (en) | 1996-11-01 |
FI924297A (en) | 1992-09-25 |
LT3535B (en) | 1995-11-27 |
DE69122092D1 (en) | 1996-10-17 |
FI924297A0 (en) | 1992-09-25 |
EP0521977A1 (en) | 1993-01-13 |
WO1991014460A1 (en) | 1991-10-03 |
HUT69168A (en) | 1995-08-28 |
NO923739L (en) | 1992-11-06 |
DK0521977T3 (en) | 1996-09-30 |
AU645796B2 (en) | 1994-01-27 |
JPH06507147A (en) | 1994-08-11 |
AU7557891A (en) | 1991-10-21 |
ATE142508T1 (en) | 1996-09-15 |
SG43931A1 (en) | 1997-11-14 |
EP0521977B1 (en) | 1996-09-11 |
EP0645146A1 (en) | 1995-03-29 |
GB9006977D0 (en) | 1990-05-23 |
NO923739D0 (en) | 1992-09-25 |
CA2079212A1 (en) | 1991-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TK9A | Rectifications: patents |
Free format text: NYCOMED IMAGING AS, NYCOVEIEN 2, P.O. BOX 4220 TORSHOV, N-0401 OSLO 4, NO, 19951130 |
|
MM9A | Lapsed patents |
Effective date: 19980602 |