GB1535223A - N-(6-acyloxybenzothiazol-2-yl)-n'-phenyl(or substituted phenyl)ureas - Google Patents
N-(6-acyloxybenzothiazol-2-yl)-n'-phenyl(or substituted phenyl)ureasInfo
- Publication number
- GB1535223A GB1535223A GB9679/76A GB967976A GB1535223A GB 1535223 A GB1535223 A GB 1535223A GB 9679/76 A GB9679/76 A GB 9679/76A GB 967976 A GB967976 A GB 967976A GB 1535223 A GB1535223 A GB 1535223A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- phenyl
- formula
- carbon atoms
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Novel phenylurea derivatives of the formula I are prepared by reacting an N-(6-hydroxybenzothiazol-2-yl)-N'-phenylurea of the formula II with an anhydride of acetic acid, propionic acid, isopropionic acid, butyric acid, isobutyric acid or benzoic acid in the presence of pyridine. In the formulae I and II, R is a hydrogen atom, a halogen atom, an alkyl group having 1-3 carbon atoms or an alkoxy group, and R' represents an alkyl radical having 1-3 carbon atoms or the phenyl radical. The novel phenylurea derivatives of the formula I are suitable for modifying the immune response, and they have a specific action against those cells which are active in the immune response. <IMAGE>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/635,832 US4046770A (en) | 1974-08-30 | 1975-11-28 | N-(6-acyloxybenzothiazol-2-yl)-N'-phenyl (or substituted phenyl)ureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1535223A true GB1535223A (en) | 1978-12-13 |
Family
ID=24549286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9679/76A Expired GB1535223A (en) | 1975-11-28 | 1976-03-11 | N-(6-acyloxybenzothiazol-2-yl)-n'-phenyl(or substituted phenyl)ureas |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5268176A (en) |
| AR (1) | AR208767A1 (en) |
| AT (1) | AT348539B (en) |
| AU (1) | AU501516B2 (en) |
| BE (1) | BE840048A (en) |
| CA (1) | CA1067499A (en) |
| CH (1) | CH608795A5 (en) |
| DD (1) | DD126038A5 (en) |
| DE (1) | DE2612541A1 (en) |
| DK (1) | DK105676A (en) |
| ES (1) | ES451021A1 (en) |
| FR (1) | FR2332752A1 (en) |
| GB (1) | GB1535223A (en) |
| GR (1) | GR61856B (en) |
| HU (1) | HU173987B (en) |
| IE (1) | IE43213B1 (en) |
| IL (1) | IL49187A (en) |
| MX (1) | MX3136E (en) |
| NL (1) | NL7602660A (en) |
| PL (1) | PL100058B1 (en) |
| PT (1) | PT64930B (en) |
| SE (1) | SE417712B (en) |
| SU (1) | SU648096A3 (en) |
| ZA (1) | ZA761477B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2949651A4 (en) * | 2013-01-22 | 2016-10-19 | Consejo Superior Investigacion | Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4380640A (en) * | 1980-01-21 | 1983-04-19 | Ciba-Geigy Corporation | Novel benzthiazolylurea derivatives, compositions containing them and their use as herbicides |
-
1976
- 1976-03-09 GR GR50270A patent/GR61856B/en unknown
- 1976-03-09 IE IE483/76A patent/IE43213B1/en unknown
- 1976-03-09 CA CA247,497A patent/CA1067499A/en not_active Expired
- 1976-03-10 ZA ZA761477A patent/ZA761477B/en unknown
- 1976-03-10 IL IL49187A patent/IL49187A/en unknown
- 1976-03-11 DK DK105676A patent/DK105676A/en unknown
- 1976-03-11 GB GB9679/76A patent/GB1535223A/en not_active Expired
- 1976-03-11 AU AU11836/76A patent/AU501516B2/en not_active Expired
- 1976-03-12 MX MX7076U patent/MX3136E/en unknown
- 1976-03-12 NL NL7602660A patent/NL7602660A/en not_active Application Discontinuation
- 1976-03-15 HU HU76EI672A patent/HU173987B/en unknown
- 1976-03-16 JP JP51029082A patent/JPS5268176A/en active Pending
- 1976-03-17 AR AR262593A patent/AR208767A1/en active
- 1976-03-22 PT PT64930A patent/PT64930B/en unknown
- 1976-03-22 SE SE7603521A patent/SE417712B/en unknown
- 1976-03-24 AT AT217876A patent/AT348539B/en not_active IP Right Cessation
- 1976-03-24 DE DE19762612541 patent/DE2612541A1/en not_active Withdrawn
- 1976-03-25 DD DD192035A patent/DD126038A5/xx unknown
- 1976-03-26 BE BE1007282A patent/BE840048A/en unknown
- 1976-03-26 FR FR7608856A patent/FR2332752A1/en active Granted
- 1976-03-29 CH CH763906A patent/CH608795A5/en not_active IP Right Cessation
- 1976-04-08 SU SU762343063A patent/SU648096A3/en active
- 1976-04-14 PL PL1976188772A patent/PL100058B1/en unknown
- 1976-08-26 ES ES451021A patent/ES451021A1/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2949651A4 (en) * | 2013-01-22 | 2016-10-19 | Consejo Superior Investigacion | Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases |
| US9592224B2 (en) | 2013-01-22 | 2017-03-14 | Donsejo Superior De Investigaciones Científicas (Csic) | Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases |
| EP3348550A1 (en) * | 2013-01-22 | 2018-07-18 | Consejo Superior de Investigaciones Cientificas (CSIC) | Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| IE43213B1 (en) | 1981-01-14 |
| IL49187A0 (en) | 1976-05-31 |
| ES451021A1 (en) | 1977-12-16 |
| SE7603521L (en) | 1977-05-29 |
| IL49187A (en) | 1979-01-31 |
| SE417712B (en) | 1981-04-06 |
| CH608795A5 (en) | 1979-01-31 |
| PT64930B (en) | 1977-08-24 |
| AT348539B (en) | 1979-02-26 |
| BE840048A (en) | 1976-09-27 |
| FR2332752B1 (en) | 1978-10-20 |
| HU173987B (en) | 1979-10-28 |
| AU501516B2 (en) | 1979-06-21 |
| DE2612541A1 (en) | 1977-06-02 |
| DD126038A5 (en) | 1977-06-15 |
| DK105676A (en) | 1977-05-29 |
| ATA217876A (en) | 1978-07-15 |
| ZA761477B (en) | 1977-10-26 |
| SU648096A3 (en) | 1979-02-15 |
| GR61856B (en) | 1979-01-30 |
| IE43213L (en) | 1977-05-28 |
| JPS5268176A (en) | 1977-06-06 |
| AU1183676A (en) | 1977-09-15 |
| CA1067499A (en) | 1979-12-04 |
| MX3136E (en) | 1980-05-06 |
| PL100058B1 (en) | 1978-08-31 |
| NL7602660A (en) | 1977-06-01 |
| PT64930A (en) | 1976-04-01 |
| FR2332752A1 (en) | 1977-06-24 |
| AR208767A1 (en) | 1977-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |