SE7612308L - METHODS OF PREPARING 2,6-DIMETHYL-3-METHOXICARBONYL-4- (2'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-5-CARBONIC ACID AISOBUTYLES AND USING IT AS A KPRPMARTERAPERTIC. - Google Patents

METHODS OF PREPARING 2,6-DIMETHYL-3-METHOXICARBONYL-4- (2'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-5-CARBONIC ACID AISOBUTYLES AND USING IT AS A KPRPMARTERAPERTIC.

Info

Publication number
SE7612308L
SE7612308L SE7612308A SE7612308A SE7612308L SE 7612308 L SE7612308 L SE 7612308L SE 7612308 A SE7612308 A SE 7612308A SE 7612308 A SE7612308 A SE 7612308A SE 7612308 L SE7612308 L SE 7612308L
Authority
SE
Sweden
Prior art keywords
dihydropyridine
nitrophenyl
dimethyl
methoxicarbonyl
kprpmarterapertic
Prior art date
Application number
SE7612308A
Other languages
Swedish (sv)
Other versions
SE423542B (en
Inventor
E Wehringer
F Bossert
A Heise
S Kazda
K Stoepel
W Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SE7612308L publication Critical patent/SE7612308L/en
Publication of SE423542B publication Critical patent/SE423542B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate of the formula <IMAGE> is prepared by reacting methyl 2'-nitrobenzylideneacetoacetate either with isobutyl beta -aminocrotonate or with isobutyl acetoacetate and ammonia. The novel compound can be used as a coronary therapeutic.
SE7612308A 1975-11-05 1976-11-04 SET TO PREPARATE 2,6-DIMETHYL-3METOXICARBONYL-4- (2'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-5-CARBONIC ACID ISOBUTYL ESTER SE423542B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2549568A DE2549568C3 (en) 1975-11-05 1975-11-05 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl) -1,4-dihydropyridine-5-carboxylic acid isobutyl ester, several processes for its preparation and pharmaceuticals containing it

Publications (2)

Publication Number Publication Date
SE7612308L true SE7612308L (en) 1977-05-06
SE423542B SE423542B (en) 1982-05-10

Family

ID=5960951

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7612308A SE423542B (en) 1975-11-05 1976-11-04 SET TO PREPARATE 2,6-DIMETHYL-3METOXICARBONYL-4- (2'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-5-CARBONIC ACID ISOBUTYL ESTER

Country Status (27)

Country Link
JP (1) JPS5259161A (en)
AT (1) AT352129B (en)
AU (1) AU498964B2 (en)
BE (1) BE847968A (en)
BG (6) BG24803A3 (en)
CA (1) CA1085406A (en)
CH (2) CH623038A5 (en)
CS (1) CS200499B2 (en)
DE (1) DE2549568C3 (en)
DK (1) DK146762C (en)
ES (2) ES452986A1 (en)
FI (1) FI60704C (en)
FR (1) FR2330395A1 (en)
GB (1) GB1516793A (en)
GR (1) GR61241B (en)
HK (1) HK12681A (en)
IE (1) IE43984B1 (en)
IL (1) IL50817A (en)
LU (2) LU88275I2 (en)
NL (2) NL175915C (en)
NO (1) NO145574C (en)
NZ (1) NZ182502A (en)
PL (2) PL105940B1 (en)
PT (1) PT65797B (en)
RO (1) RO70295A (en)
SE (1) SE423542B (en)
ZA (1) ZA766622B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE3212736A1 (en) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen USE OF DIHYDROPYRIDINES IN MEDICINAL PRODUCTS WITH SALIDIURETIC EFFECT
DE3222367A1 (en) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Use of 1,4-dihydropyridines in antiarteriosclerotics and preparation thereof
JPS5982192U (en) * 1982-11-27 1984-06-02 エムケ−精工株式会社 door
DE3312216A1 (en) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING SYMMETRIC 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS
DE3312283A1 (en) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING UNBALANCED 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (en) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals

Also Published As

Publication number Publication date
LU76133A1 (en) 1977-06-02
DK146762B (en) 1983-12-27
RO70295A (en) 1981-08-17
NO763608L (en) 1977-05-06
BG24668A3 (en) 1978-04-12
IE43984L (en) 1977-05-05
BG25079A3 (en) 1978-07-12
ATA814276A (en) 1979-02-15
PL105940B1 (en) 1979-11-30
NL7612198A (en) 1977-05-09
FI60704B (en) 1981-11-30
FI763160A (en) 1977-05-06
AU1935876A (en) 1978-05-11
AT352129B (en) 1979-09-10
IE43984B1 (en) 1981-07-15
ES452986A1 (en) 1977-12-16
IL50817A (en) 1979-07-25
FI60704C (en) 1982-03-10
HK12681A (en) 1981-04-10
CH622779A5 (en) 1981-04-30
GR61241B (en) 1978-10-12
DE2549568C3 (en) 1981-10-29
FR2330395B1 (en) 1978-12-22
BG25078A3 (en) 1978-07-12
NZ182502A (en) 1978-07-28
DK146762C (en) 1984-06-12
DK498476A (en) 1977-05-06
GB1516793A (en) 1978-07-05
NL930035I1 (en) 1993-08-02
CA1085406A (en) 1980-09-09
JPS5259161A (en) 1977-05-16
NO145574B (en) 1982-01-11
BG24803A3 (en) 1978-05-12
DE2549568A1 (en) 1977-05-18
CS200499B2 (en) 1980-09-15
SE423542B (en) 1982-05-10
LU88275I2 (en) 1994-02-03
BG24805A3 (en) 1978-05-12
AU498964B2 (en) 1979-03-29
PL106084B1 (en) 1979-11-30
BG24804A3 (en) 1978-05-12
DE2549568B2 (en) 1980-08-21
PT65797A (en) 1976-12-01
ZA766622B (en) 1977-10-26
FR2330395A1 (en) 1977-06-03
ES463166A1 (en) 1978-07-16
JPS5647185B2 (en) 1981-11-07
CH623038A5 (en) 1981-05-15
IL50817A0 (en) 1977-01-31
PT65797B (en) 1978-05-12
NL930035I2 (en) 1993-10-01
NL175915C (en) 1985-01-16
BE847968A (en) 1977-05-04
NO145574C (en) 1982-04-21

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