GB1530921A - Desacylpepsidine and the preparation thereof - Google Patents
Desacylpepsidine and the preparation thereofInfo
- Publication number
- GB1530921A GB1530921A GB49988/75A GB4998875A GB1530921A GB 1530921 A GB1530921 A GB 1530921A GB 49988/75 A GB49988/75 A GB 49988/75A GB 4998875 A GB4998875 A GB 4998875A GB 1530921 A GB1530921 A GB 1530921A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- amino
- hydroxy
- methylheptanoylalanyl
- deacylpepsidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The deacylpepsidin valylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxy -6-methylheptanoic acid of the formula <IMAGE> is obtained by microbiological means, starting from the acylpentapeptide N-acylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-h ydroxy-6-methylheptanoic acid of the formula <IMAGE> in which R is an acyl group. The compound of the second formula is converted into the product of the first formula by contacting with bacteria of the species Bacillus pumilus or with their acellular culture preparations. The employed bacteria are specifically those of the strain Bacillus pumilus Kawaguchi EF 49-210 (ATCC No. 31132). The deacylpepsidin of the formula (I) is obtained in higher yields and greater purities than in known processes. It has high activity as a pepsin inhibitor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49138862A JPS5167791A (en) | 1974-12-05 | 1974-12-05 | Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1530921A true GB1530921A (en) | 1978-11-01 |
Family
ID=15231860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB49988/75A Expired GB1530921A (en) | 1974-12-05 | 1975-12-05 | Desacylpepsidine and the preparation thereof |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS5167791A (en) |
CA (1) | CA1053167A (en) |
CH (1) | CH620244A5 (en) |
DE (2) | DE2560238C2 (en) |
FR (1) | FR2293215A1 (en) |
GB (1) | GB1530921A (en) |
NL (1) | NL7514241A (en) |
SE (1) | SE423710B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4091093A (en) * | 1975-09-12 | 1978-05-23 | Sumitomo Chemical Company Limited | Protease inhibitors |
JPS56164153A (en) * | 1980-05-20 | 1981-12-17 | Eisai Co Ltd | Novel desacylvalypepsidin derivative and its preparation |
JPS56164152A (en) * | 1980-05-20 | 1981-12-17 | Eisai Co Ltd | Novel desacylpepsidin derivative and its preparation |
JPS57189651U (en) * | 1981-05-27 | 1982-12-01 | ||
JPS5956948A (en) * | 1982-09-28 | 1984-04-02 | Nippon Kokan Kk <Nkk> | Mold for horizontal continuous casting machine |
JPS60213347A (en) * | 1984-04-06 | 1985-10-25 | Kawasaki Heavy Ind Ltd | Billet drawing device for continuous casting |
-
1974
- 1974-12-05 JP JP49138862A patent/JPS5167791A/en active Granted
-
1975
- 1975-12-04 DE DE2560238A patent/DE2560238C2/en not_active Expired
- 1975-12-04 FR FR7537098A patent/FR2293215A1/en active Granted
- 1975-12-04 DE DE2554636A patent/DE2554636C2/en not_active Expired
- 1975-12-04 CH CH1581875A patent/CH620244A5/en not_active IP Right Cessation
- 1975-12-04 SE SE7513671A patent/SE423710B/en not_active IP Right Cessation
- 1975-12-05 GB GB49988/75A patent/GB1530921A/en not_active Expired
- 1975-12-05 NL NL7514241A patent/NL7514241A/en not_active Application Discontinuation
- 1975-12-05 CA CA241,153A patent/CA1053167A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2560238C2 (en) | 1984-07-19 |
SE7513671L (en) | 1976-06-08 |
CH620244A5 (en) | 1980-11-14 |
SE423710B (en) | 1982-05-24 |
DE2554636C2 (en) | 1983-02-17 |
FR2293215A1 (en) | 1976-07-02 |
JPS5339514B2 (en) | 1978-10-21 |
JPS5167791A (en) | 1976-06-11 |
NL7514241A (en) | 1976-06-09 |
CA1053167A (en) | 1979-04-24 |
FR2293215B1 (en) | 1978-07-28 |
DE2554636A1 (en) | 1976-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |