GB1531212A - Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof - Google Patents

Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof

Info

Publication number
GB1531212A
GB1531212A GB48522/74A GB4852274A GB1531212A GB 1531212 A GB1531212 A GB 1531212A GB 48522/74 A GB48522/74 A GB 48522/74A GB 4852274 A GB4852274 A GB 4852274A GB 1531212 A GB1531212 A GB 1531212A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acids
acyloxymethylceph
salts
enzymatic hydrolysis
esterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48522/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB48522/74A priority Critical patent/GB1531212A/en
Priority to US05/628,057 priority patent/US3976546A/en
Priority to AU86357/75A priority patent/AU500894B2/en
Priority to NLAANVRAGE7513065,A priority patent/NL177422C/en
Priority to JP13460975A priority patent/JPS5646839B2/ja
Priority to ZA00757003A priority patent/ZA757003B/en
Priority to DE19752550110 priority patent/DE2550110A1/en
Priority to CH1446275A priority patent/CH616165A5/en
Priority to FR7534059A priority patent/FR2290444A1/en
Publication of GB1531212A publication Critical patent/GB1531212A/en
Priority to JP5287481A priority patent/JPS56169595A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

3-Hydroxymethylceph-3-em-4-carboxylic acids are prepared by esterase-catalysed hydrolysis from the corresponding 3-acyloxymethylceph-3-em-4-carboxylic acids. The esterase used for this purpose is obtained by cultivation of a microorganism from the Basidiomycetes class. This process is used particularly advantageously for compounds of the formula I in which the symbols R<1>, R<2>, R<3> and B have the meanings stated in Claim 6, in particular for cephalosporin C.
GB48522/74A 1974-11-08 1974-11-08 Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof Expired GB1531212A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB48522/74A GB1531212A (en) 1974-11-08 1974-11-08 Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof
US05/628,057 US3976546A (en) 1974-11-08 1975-11-03 Cephalosporins
AU86357/75A AU500894B2 (en) 1974-11-08 1975-11-06 Cephalosporin hydrolysis
ZA00757003A ZA757003B (en) 1974-11-08 1975-11-07 Improvements in or relating to cephalosporins
JP13460975A JPS5646839B2 (en) 1974-11-08 1975-11-07
NLAANVRAGE7513065,A NL177422C (en) 1974-11-08 1975-11-07 PROCESS FOR PREPARING A 3-HYDROXYMETHYLCEPHALOSPORIN AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION CONTAINING SUCH A COMPOUND
DE19752550110 DE2550110A1 (en) 1974-11-08 1975-11-07 PROCESS FOR THE CONVERSION OF CEPHALOSPORINE COMPOUNDS
CH1446275A CH616165A5 (en) 1974-11-08 1975-11-07 Process for converting a 3-acyloxymethylceph-3-em-4-carboxylic acid into a 3-hydroxymethylceph-3-em-4-carboxylic acid.
FR7534059A FR2290444A1 (en) 1974-11-08 1975-11-07 PROCESS FOR THE CONVERSION OF 3-ACYLOXYMETHYL CEPHALOSPORINS IN 3-HYDROXYMETHYL CEPHALOSPORINS
JP5287481A JPS56169595A (en) 1974-11-08 1981-04-08 Preparation of cephalosporine compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB48522/74A GB1531212A (en) 1974-11-08 1974-11-08 Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof

Publications (1)

Publication Number Publication Date
GB1531212A true GB1531212A (en) 1978-11-08

Family

ID=10448929

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48522/74A Expired GB1531212A (en) 1974-11-08 1974-11-08 Enzymatic hydrolysis of 3-acyloxymethylceph-3-em-4-carboxylic acids or salts thereof

Country Status (8)

Country Link
JP (2) JPS5646839B2 (en)
AU (1) AU500894B2 (en)
CH (1) CH616165A5 (en)
DE (1) DE2550110A1 (en)
FR (1) FR2290444A1 (en)
GB (1) GB1531212A (en)
NL (1) NL177422C (en)
ZA (1) ZA757003B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414328A (en) 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
AU729815B2 (en) * 1996-09-18 2001-02-08 Bristol-Myers Squibb Company Cephalosporin esterase gene from Rhodosporidium toruloides

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT378003B (en) * 1979-07-19 1985-06-10 Glaxo Group Ltd METHOD FOR PRODUCING DESACTYLCEPHALOSPORIN C
US5466787A (en) * 1993-11-15 1995-11-14 Bristol-Myers Squibb Company Process for preparing AZT
US5512454A (en) * 1994-02-03 1996-04-30 Bristol-Myers Squibb Company Enzymatic acylation of 3-hydroxymethyl cephalosporins

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414328A (en) 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
AU729815B2 (en) * 1996-09-18 2001-02-08 Bristol-Myers Squibb Company Cephalosporin esterase gene from Rhodosporidium toruloides

Also Published As

Publication number Publication date
JPS5646839B2 (en) 1981-11-05
ZA757003B (en) 1976-10-27
JPS5176489A (en) 1976-07-02
FR2290444A1 (en) 1976-06-04
CH616165A5 (en) 1980-03-14
JPS56169595A (en) 1981-12-26
NL177422B (en) 1985-04-16
FR2290444B1 (en) 1979-03-23
JPS6111600B2 (en) 1986-04-03
NL177422C (en) 1985-09-16
DE2550110A1 (en) 1976-05-13
NL7513065A (en) 1976-05-11
AU500894B2 (en) 1979-06-07
AU8635775A (en) 1977-05-12

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19941031