GB1521458A - Hypolipidemic rho-aminobenzoic acids - Google Patents

Hypolipidemic rho-aminobenzoic acids

Info

Publication number
GB1521458A
GB1521458A GB1803/77A GB180377A GB1521458A GB 1521458 A GB1521458 A GB 1521458A GB 1803/77 A GB1803/77 A GB 1803/77A GB 180377 A GB180377 A GB 180377A GB 1521458 A GB1521458 A GB 1521458A
Authority
GB
United Kingdom
Prior art keywords
hypolipidemic
rho
ylmethylamino
benzodioxol
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1803/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of GB1521458A publication Critical patent/GB1521458A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Schiff's bases of the formula I <IMAGE> in which R is hydrogen or lower alkyl are obtained by reacting piperonal with p-aminobenzoic acid or with a p-aminobenzoic ester. 4-(1,3-Benzodioxol-5-ylmethylamino)benzoic acid and 4-(1,3-benzodioxol-5-ylmethylamino)benzoic esters of the formula II <IMAGE> in which R is hydrogen or lower alkyl are obtained by reducing Schiff's bases of the formula I. The compound 4-(1,3-benzodioxol-5-ylmethylamino)benzoic acid which can be prepared according to the invention can be used, for example, for the reduction of the lipid level in the plasma of animals.
GB1803/77A 1976-01-19 1977-01-17 Hypolipidemic rho-aminobenzoic acids Expired GB1521458A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65009076A 1976-01-19 1976-01-19

Publications (1)

Publication Number Publication Date
GB1521458A true GB1521458A (en) 1978-08-16

Family

ID=24607411

Family Applications (2)

Application Number Title Priority Date Filing Date
GB52242/77A Expired GB1521459A (en) 1976-01-19 1977-01-17 Hypolipidemic rho-aminobenzoic acids
GB1803/77A Expired GB1521458A (en) 1976-01-19 1977-01-17 Hypolipidemic rho-aminobenzoic acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB52242/77A Expired GB1521459A (en) 1976-01-19 1977-01-17 Hypolipidemic rho-aminobenzoic acids

Country Status (14)

Country Link
JP (1) JPS5289660A (en)
AT (1) AT347923B (en)
AU (1) AU500881B2 (en)
BE (1) BE850516A (en)
CA (1) CA1072969A (en)
CH (1) CH628340A5 (en)
DE (1) DE2702058C2 (en)
DK (1) DK153471C (en)
FR (1) FR2338040A1 (en)
GB (2) GB1521459A (en)
IE (1) IE44858B1 (en)
NL (1) NL7700480A (en)
NO (1) NO145839C (en)
SE (1) SE435175B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0424904Y2 (en) * 1987-09-18 1992-06-12

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE716668C (en) * 1938-02-15 1942-01-27 Dr Aladar Skita Process for the preparation of derivatives of substituted aminobenzoic acids
FR2080069A5 (en) * 1970-02-23 1971-11-12 Commissariat Energie Atomique
US3868416A (en) * 1973-10-01 1975-02-25 American Cyanamid Co Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives

Also Published As

Publication number Publication date
DE2702058A1 (en) 1977-07-28
SE7700490L (en) 1977-07-20
AU500881B2 (en) 1979-06-07
CA1072969A (en) 1980-03-04
IE44858L (en) 1977-07-19
AU2114077A (en) 1978-07-13
JPS6233230B2 (en) 1987-07-20
GB1521459A (en) 1978-08-16
BE850516A (en) 1977-07-19
DK153471C (en) 1988-11-21
CH628340A5 (en) 1982-02-26
DE2702058C2 (en) 1985-09-19
NO145839B (en) 1982-03-01
DK153471B (en) 1988-07-18
DK8177A (en) 1977-07-20
ATA31277A (en) 1978-06-15
IE44858B1 (en) 1982-04-21
FR2338040B1 (en) 1980-04-30
NO145839C (en) 1982-06-09
AT347923B (en) 1979-01-25
FR2338040A1 (en) 1977-08-12
NL7700480A (en) 1977-07-21
NO770151L (en) 1977-07-20
SE435175B (en) 1984-09-10
JPS5289660A (en) 1977-07-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940117