GB1489088A - Aminoketones - Google Patents
AminoketonesInfo
- Publication number
- GB1489088A GB1489088A GB23143/77A GB2314377A GB1489088A GB 1489088 A GB1489088 A GB 1489088A GB 23143/77 A GB23143/77 A GB 23143/77A GB 2314377 A GB2314377 A GB 2314377A GB 1489088 A GB1489088 A GB 1489088A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- chain
- group
- carbon atoms
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1489088 Aminoketones F HOFFMANN-LA ROCHE & CO AG 20 Dec 1974 [21 Dec 1973] 23143/77 Divided out of 1489086 Heading C2C The invention comprises novel compounds (I) wherein R represents a group of the Formula (Ia) or (Ib) in which R 1 , R 2 and R 3 each represent a hydrogen or halogen atom or a lower alkyl, lower alkoxy, aryl-(lower alkoxy), aryloxy, phenyl, nitro, amino, lower alkylthio, trifluoromethyl, hydroxy, cyano, di(lower alkyl)amino, lower alkanoylamino, carboxyl, lower alkoxycarbonyl, lower alkylsulphonyl, hydroxymethyl, lower alkanoyloxy, amido, lower alkanoyl, sulphamoyl, mono(lower alkyl) sulphamoyl, di(lower alkyl) sulphamoyl, aminocarbonyloxy, mono(lower alkyl) aminocarbonyloxy or (lower alkylamino)-(lower alkyl) group or two adjacent R 1 , R 2 and R 3 symbols together represent a methylenedioxy, ethylenedioxy or butadien- 1,3-ylene-1,4 group, R 4 represents a hydrogen atom or a lower alkyl group, R 5 , R 6 and R 7 each represent a hydrogen or halogen atom or a lower alkyl, lower alkoxy, hydroxy or benzyloxy group or two adjacent R 5 , R 6 and R 7 symbols together represent a methylenedioxy or ethylenedioxy group, Y represents a straight-chain or branched-chain, optionally hydroxy-substituted, aliphatic group containing 2-8 carbon atoms, of which 2-4 carbon atoms are present in the chain, and Z represents a straight-chain or branched-chain, optionally hydroxy-substituted aliphatic group containing 1-8 carbon atoms, of which 1-4 carbon atoms are present in the chain, and m stands for zero or 1, or an acid addition salt thereof; the groups qualified by lower contain up to 6 carbons and aryl signifies phenyl optionally substituted by halogen, lower alkyl, lower alkoxy, NO 2 and amino. The compounds are made by acylating appropriate amines utilizing RCOY.Cl. 3,4 - Dimethoxy - γ - chlorobutyrophenone is made by condensing veratrol and 4-chlorobutyric acid in the presence of polyphosphoric acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1803073A CH611614A5 (en) | 1973-12-21 | 1973-12-21 | Process for the preparation of heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1489088A true GB1489088A (en) | 1977-10-19 |
Family
ID=4429892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55146/74A Expired GB1489086A (en) | 1973-12-21 | 1974-12-20 | Dithiolanes and dithianes |
| GB23143/77A Expired GB1489088A (en) | 1973-12-21 | 1974-12-20 | Aminoketones |
| GB23144/77A Expired GB1489087A (en) | 1973-12-21 | 1974-12-20 | Dithianes and dithiolanes |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55146/74A Expired GB1489086A (en) | 1973-12-21 | 1974-12-20 | Dithiolanes and dithianes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23144/77A Expired GB1489087A (en) | 1973-12-21 | 1974-12-20 | Dithianes and dithiolanes |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS595594B2 (en) |
| AT (5) | AT344693B (en) |
| AU (1) | AU511714B2 (en) |
| BE (1) | BE823625A (en) |
| CA (4) | CA1057295A (en) |
| CH (3) | CH611614A5 (en) |
| DD (1) | DD116829A5 (en) |
| DE (2) | DE2460593C3 (en) |
| DK (1) | DK148323C (en) |
| ES (5) | ES433172A1 (en) |
| FI (1) | FI67216C (en) |
| FR (1) | FR2255064B1 (en) |
| GB (3) | GB1489086A (en) |
| HK (1) | HK43380A (en) |
| HU (1) | HU170429B (en) |
| IE (1) | IE40788B1 (en) |
| IL (3) | IL46146A (en) |
| LU (1) | LU71530A1 (en) |
| NL (1) | NL158496B (en) |
| NO (1) | NO142669C (en) |
| PH (3) | PH19393A (en) |
| SE (2) | SE415763B (en) |
| YU (1) | YU39311B (en) |
| ZA (1) | ZA747526B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434179A (en) * | 1989-06-06 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Method for improving brain function using cholinesterase-inhibiting aminoketone compounds |
| EP1466625A1 (en) * | 2001-12-28 | 2004-10-13 | Takeda Chemical Industries, Ltd. | Preventives/remedies for urinary disturbance |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2515173A1 (en) * | 1981-10-28 | 1983-04-29 | Delalande Sa | 3-Methoxy 4-alkoxy benzaldehyde(s) - useful as intermediates for antibacterials, esp. trimethoprim and tetroxoprim |
| JPS60142297U (en) * | 1984-02-29 | 1985-09-20 | 株式会社豊田自動織機製作所 | Rotating device for swiveling driver's seat in forklift |
| JPS62171328U (en) * | 1986-04-23 | 1987-10-30 | ||
| DE3642331A1 (en) * | 1986-12-11 | 1988-06-23 | Basf Ag | BASICLY SUBSTITUTED PHENYL ACETONITRILES, THEIR PRODUCTION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| US20100137403A1 (en) * | 2008-07-10 | 2010-06-03 | Scott Malstrom | Method for enhancing cognition or inhibiting cognitive decline |
-
1973
- 1973-12-21 CH CH1803073A patent/CH611614A5/en not_active IP Right Cessation
-
1974
- 1974-07-19 PH PH20012A patent/PH19393A/en unknown
- 1974-11-25 ZA ZA00747526A patent/ZA747526B/en unknown
- 1974-11-28 IL IL46146A patent/IL46146A/en unknown
- 1974-12-05 FI FI3527/74A patent/FI67216C/en active
- 1974-12-09 IE IE2531/74A patent/IE40788B1/en unknown
- 1974-12-17 PH PH16639A patent/PH13326A/en unknown
- 1974-12-18 YU YU3368/74A patent/YU39311B/en unknown
- 1974-12-18 NL NL7416507.A patent/NL158496B/en not_active IP Right Cessation
- 1974-12-18 CA CA216,313A patent/CA1057295A/en not_active Expired
- 1974-12-19 LU LU71530A patent/LU71530A1/xx unknown
- 1974-12-19 DK DK668174A patent/DK148323C/en not_active IP Right Cessation
- 1974-12-19 DD DD183214A patent/DD116829A5/xx unknown
- 1974-12-19 SE SE7416086A patent/SE415763B/en not_active IP Right Cessation
- 1974-12-20 AT AT1022674A patent/AT344693B/en not_active IP Right Cessation
- 1974-12-20 NO NO744615A patent/NO142669C/en unknown
- 1974-12-20 DE DE2460593A patent/DE2460593C3/en not_active Expired
- 1974-12-20 DE DE2463173A patent/DE2463173C2/de not_active Expired
- 1974-12-20 GB GB55146/74A patent/GB1489086A/en not_active Expired
- 1974-12-20 GB GB23143/77A patent/GB1489088A/en not_active Expired
- 1974-12-20 HU HUHO1757A patent/HU170429B/hu unknown
- 1974-12-20 JP JP49145875A patent/JPS595594B2/en not_active Expired
- 1974-12-20 BE BE151729A patent/BE823625A/en not_active IP Right Cessation
- 1974-12-20 ES ES433172A patent/ES433172A1/en not_active Expired
- 1974-12-20 GB GB23144/77A patent/GB1489087A/en not_active Expired
- 1974-12-23 FR FR7442521A patent/FR2255064B1/fr not_active Expired
-
1976
- 1976-09-01 ES ES451134A patent/ES451134A1/en not_active Expired
- 1976-09-01 ES ES451137A patent/ES451137A1/en not_active Expired
- 1976-09-01 ES ES451135A patent/ES451135A1/en not_active Expired
- 1976-09-01 ES ES451136A patent/ES451136A1/en not_active Expired
-
1977
- 1977-07-19 PH PH20013A patent/PH13396A/en unknown
- 1977-08-29 IL IL52843A patent/IL52843A0/en not_active IP Right Cessation
- 1977-08-29 IL IL52844A patent/IL52844A0/en unknown
-
1978
- 1978-01-06 AU AU32242/78A patent/AU511714B2/en not_active Expired
- 1978-01-19 AT AT38778A patent/AT349012B/en not_active IP Right Cessation
- 1978-01-19 AT AT38978A patent/AT350053B/en not_active IP Right Cessation
- 1978-01-19 AT AT38878A patent/AT349013B/en not_active IP Right Cessation
- 1978-01-19 AT AT39178A patent/AT349014B/en not_active IP Right Cessation
- 1978-04-27 SE SE7804879A patent/SE434746B/en not_active IP Right Cessation
- 1978-06-15 CH CH654178A patent/CH620921A5/en not_active IP Right Cessation
- 1978-06-15 CH CH654078A patent/CH620920A5/en not_active IP Right Cessation
-
1979
- 1979-03-26 CA CA324,131A patent/CA1079290A/en not_active Expired
- 1979-03-26 CA CA324,130A patent/CA1086320A/en not_active Expired
- 1979-03-26 CA CA324,132A patent/CA1072966A/en not_active Expired
-
1980
- 1980-08-14 HK HK433/80A patent/HK43380A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434179A (en) * | 1989-06-06 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Method for improving brain function using cholinesterase-inhibiting aminoketone compounds |
| EP1466625A1 (en) * | 2001-12-28 | 2004-10-13 | Takeda Chemical Industries, Ltd. | Preventives/remedies for urinary disturbance |
| EP1466625A4 (en) * | 2001-12-28 | 2007-07-18 | Takeda Pharmaceutical | Preventives/remedies for urinary disturbance |
| US7462628B2 (en) | 2001-12-28 | 2008-12-09 | Takeda Pharmaceutical Company Limited | Preventives/remedies for urinary disturbance |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |