GB1486826A - Method for conducting surface immunological tests - Google Patents
Method for conducting surface immunological testsInfo
- Publication number
- GB1486826A GB1486826A GB38103/74A GB3810374A GB1486826A GB 1486826 A GB1486826 A GB 1486826A GB 38103/74 A GB38103/74 A GB 38103/74A GB 3810374 A GB3810374 A GB 3810374A GB 1486826 A GB1486826 A GB 1486826A
- Authority
- GB
- United Kingdom
- Prior art keywords
- protein
- molecules
- bimolecular
- layer
- immunologically reactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Suitable substrates are coated with a monomolecular protein layer consisting of an immunologically reactive first protein and of an inert protein. The molecules of the first protein are moreover separated from each other by the molecules of the inert protein. The substrate with a monomolecular coating is contacted with a solution of an immunologically reactive, second protein which is specific for the first protein. This results in the second protein molecules binding to the first protein molecules to form a bimolecular layer on the substrate. In contrast to known substrates of this type, the second protein molecules show after formation of the bimolecular layer a larger number of active sites for another immunological reaction. In addition, when large first proteins are used there is in this way a significant increase in the contrast between the mono- and the bimolecular parts of the layer. The substrates with a bimolecular coating obtained in this way can be used for the detection and determination of various other immunologically reactive substances.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39295073A | 1973-08-30 | 1973-08-30 | |
| US39295173A | 1973-08-30 | 1973-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1486826A true GB1486826A (en) | 1977-09-28 |
Family
ID=27014084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38103/74A Expired GB1486826A (en) | 1973-08-30 | 1974-08-30 | Method for conducting surface immunological tests |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5916669B2 (en) |
| AT (1) | AT347598B (en) |
| BR (1) | BR7407193D0 (en) |
| CH (1) | CH617012A5 (en) |
| DE (1) | DE2440367C2 (en) |
| DK (1) | DK151240C (en) |
| FR (1) | FR2257259B1 (en) |
| GB (1) | GB1486826A (en) |
| IT (1) | IT1020283B (en) |
| MX (1) | MX3121E (en) |
| NL (1) | NL177628C (en) |
| SE (1) | SE457118B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189464A (en) * | 1978-05-05 | 1980-02-19 | Institute For Cancer Research | Hepatitis B testing reagent and method |
| WO1983002669A1 (en) * | 1982-01-27 | 1983-08-04 | Malmqvist, Magnus | Silanization of surfaces |
| US4931384A (en) * | 1982-12-21 | 1990-06-05 | Ares-Serono N.V. | Optical assay technique |
| US5486452A (en) * | 1981-04-29 | 1996-01-23 | Ciba-Geigy Corporation | Devices and kits for immunological analysis |
| CN112924666A (en) * | 2019-12-05 | 2021-06-08 | 菲鹏生物股份有限公司 | Solid support coating product, preparation method, application and product thereof |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2638207C2 (en) * | 1975-08-27 | 1985-10-03 | General Electric Co., Schenectady, N.Y. | Process for forming multimolecular immunologically complexed films |
| DE2729555C2 (en) * | 1976-07-06 | 1985-12-12 | Becton, Dickinson and Co., East Rutherford, N.J. | Process for forming a coating of a receptor on a plastic substrate, the product obtained therefrom and its use |
| AU531777B2 (en) * | 1978-04-05 | 1983-09-08 | Syva Co. | Label/solid conjugate immunoassay system |
| US4233402A (en) * | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4822566A (en) * | 1985-11-19 | 1989-04-18 | The Johns Hopkins University | Optimized capacitive sensor for chemical analysis and measurement |
| US5114674A (en) * | 1987-05-01 | 1992-05-19 | Biotronic Systems Corporation | Added array of molecular chains for interfering with electrical fields |
-
1974
- 1974-08-23 DE DE2440367A patent/DE2440367C2/en not_active Expired
- 1974-08-28 FR FR7429366A patent/FR2257259B1/fr not_active Expired
- 1974-08-28 BR BR7193/74A patent/BR7407193D0/en unknown
- 1974-08-28 DK DK457174A patent/DK151240C/en not_active IP Right Cessation
- 1974-08-29 IT IT26721/74A patent/IT1020283B/en active
- 1974-08-29 SE SE7410971A patent/SE457118B/en not_active IP Right Cessation
- 1974-08-29 JP JP49098437A patent/JPS5916669B2/en not_active Expired
- 1974-08-29 MX MX100002U patent/MX3121E/en unknown
- 1974-08-30 GB GB38103/74A patent/GB1486826A/en not_active Expired
- 1974-08-30 NL NLAANVRAGE7411596,A patent/NL177628C/en not_active IP Right Cessation
- 1974-08-30 AT AT704774A patent/AT347598B/en not_active IP Right Cessation
- 1974-08-30 CH CH1185474A patent/CH617012A5/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189464A (en) * | 1978-05-05 | 1980-02-19 | Institute For Cancer Research | Hepatitis B testing reagent and method |
| US5486452A (en) * | 1981-04-29 | 1996-01-23 | Ciba-Geigy Corporation | Devices and kits for immunological analysis |
| WO1983002669A1 (en) * | 1982-01-27 | 1983-08-04 | Malmqvist, Magnus | Silanization of surfaces |
| US4833093A (en) * | 1982-01-27 | 1989-05-23 | Forsvarets Forskningsanstalt | Method of silanization of surfaces |
| US4931384A (en) * | 1982-12-21 | 1990-06-05 | Ares-Serono N.V. | Optical assay technique |
| US5118608A (en) * | 1982-12-21 | 1992-06-02 | Ares-Serono N.V. | Optical assay technique |
| CN112924666A (en) * | 2019-12-05 | 2021-06-08 | 菲鹏生物股份有限公司 | Solid support coating product, preparation method, application and product thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA704774A (en) | 1978-05-15 |
| JPS5070517A (en) | 1975-06-12 |
| NL7411596A (en) | 1975-03-04 |
| AU7251474A (en) | 1976-02-26 |
| BR7407193D0 (en) | 1975-06-24 |
| DE2440367A1 (en) | 1975-03-06 |
| DK151240C (en) | 1988-04-18 |
| FR2257259A1 (en) | 1975-08-08 |
| DK457174A (en) | 1975-04-28 |
| NL177628C (en) | 1985-10-16 |
| SE7410971L (en) | 1975-03-03 |
| SE457118B (en) | 1988-11-28 |
| AT347598B (en) | 1979-01-10 |
| DE2440367C2 (en) | 1984-03-15 |
| IT1020283B (en) | 1977-12-20 |
| DK151240B (en) | 1987-11-16 |
| JPS5916669B2 (en) | 1984-04-17 |
| CH617012A5 (en) | 1980-04-30 |
| FR2257259B1 (en) | 1982-07-02 |
| MX3121E (en) | 1980-04-21 |
| NL177628B (en) | 1985-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU672638B2 (en) | Improved sensor membranes | |
| GB1548741A (en) | Heterogenous specific binding assay method and test systemfor use therein | |
| US5798030A (en) | Biosensor membranes | |
| EP0101912A3 (en) | Antigen assay method and kit | |
| GB1486826A (en) | Method for conducting surface immunological tests | |
| EP0397113A3 (en) | Method of detecting specific binding substances in body fluids | |
| EP0312135A3 (en) | Polymer coated solid matrices and use in immunoassays | |
| ATE158406T1 (en) | METHOD FOR AUTOMATICALLY PROCESSING LIQUIDS FOR LABORATORY AND BIOANALYTICAL PURPOSES USING A ROTOR | |
| IE820998L (en) | Immunological analysis | |
| ES455868A1 (en) | Method of forming and depositing monomolecular layers of amphiphilic molecules on a substrate | |
| JPS6454354A (en) | Test carrier for measuring analysis object comprising whole blood and making thereof | |
| DE3485303D1 (en) | TEST PROCEDURE. | |
| CA1031676A (en) | Method and reagent for the enzyme kinetic determination of the concentration of a substrate | |
| EP0366241A3 (en) | Device with adsorbent surface and method | |
| ES420627A1 (en) | Method of detecting defects and composition therefor | |
| SE7409777L (en) | ||
| CA1019466A (en) | Method for determining whether holes in insulated layer of semiconductor substrate are fully open | |
| JPS5241654A (en) | Formation of roughened coating layer by electro-phoresis and coating c omposition for the same | |
| EP0296036A3 (en) | Reversed competitive solid phase immunoassay for detecting single epitope, analytes and kit therefor | |
| JPS56130976A (en) | Photoelectric converter | |
| DK134651C (en) | SUBSTRATE FOR THE DETERMINATION OF DESOXYRIBONUCLEASE AND ITS ANTIBODIES CONTAINING A HIGH MOLECULE COMPLEX OF DESOXYRIBONUCLEIC ACID AND A DYE AND THE PROCEDURE OF FRONT | |
| AU7534287A (en) | Method for diagnostic immunoassay by solid phase separation | |
| SE8503429D0 (en) | BLODCELLSTYPNING | |
| SU524414A1 (en) | Adsorption investigating method | |
| SU1014020A1 (en) | Method of producing specimen for measuring magnetic recording medium working layer cohesive strength |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 746 | Register noted 'licences of right' (sect. 46/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |