GB1469745A - Phenylethylamine derivatives - Google Patents
Phenylethylamine derivativesInfo
- Publication number
- GB1469745A GB1469745A GB3541975A GB3541975A GB1469745A GB 1469745 A GB1469745 A GB 1469745A GB 3541975 A GB3541975 A GB 3541975A GB 3541975 A GB3541975 A GB 3541975A GB 1469745 A GB1469745 A GB 1469745A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- addition
- pharmaceutically acceptable
- acid
- phenylethylamine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007925 phenylethylamine derivatives Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- TXDQJVBNHPYFMC-UHFFFAOYSA-N 1-[3-(trifluoromethylsulfanyl)phenyl]propan-2-one Chemical compound CC(=O)CC1=CC=CC(SC(F)(F)F)=C1 TXDQJVBNHPYFMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002891 anorexigenic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- -1 ethylidene-amino Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1469745 Phenylethylamine derivatives SYNTHELABO 27 Aug 1975 [6 Sept 1974] 35419/75 Addition to 1415471 Heading C2C The invention comprises compounds of the formula wherein n is 0, 1 or 2 and m is an integer from 1 to 4, and their acid-addition salts with pharmaceutically acceptable organic an inorganic acids. They may be obtained by condensing 1- (3 - trifluoromethylthiophenyl)propan - 2 - one with an amine of the formula and reducing the ethylidene-amino intermediate obtained, and optionally converting the base obtained into an acid-addition salt thereof. Pharmaceutical compositions having powerful anorexigenic properties comprise compounds of Formula II above or a pharmaceutically acceptable salt thereof, and a compatible pharmaceutical carrier, in forms suitable for oral administration.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7430284A FR2283673A1 (en) | 1974-09-06 | 1974-09-06 | NEW M-TRIFLUOROMETHYLTHIO PHENETHYLAMINE DERIVATIVES, THEIR SALTS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING IT |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1469745A true GB1469745A (en) | 1977-04-06 |
Family
ID=9142841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3541975A Expired GB1469745A (en) | 1974-09-06 | 1975-08-27 | Phenylethylamine derivatives |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS5163153A (en) |
BE (1) | BE832999R (en) |
DK (1) | DK398675A (en) |
ES (1) | ES440767A2 (en) |
FR (1) | FR2283673A1 (en) |
GB (1) | GB1469745A (en) |
NL (1) | NL7510489A (en) |
SE (1) | SE7509884L (en) |
ZA (1) | ZA755417B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2447907A1 (en) * | 1979-02-05 | 1980-08-29 | Synthelabo | Anorexics used to treat obesity - are 1-3-tri:fluoro:methyl-sulphonyl or sulphinyl-phenyl-2-amino-propane(s) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1218135A (en) * | 1967-07-28 | 1971-01-06 | Abbott Lab | Substituted phenethylamine derivatives |
FR2186248B1 (en) * | 1972-05-31 | 1975-11-28 | Synthelabo |
-
1974
- 1974-09-06 FR FR7430284A patent/FR2283673A1/en active Granted
-
1975
- 1975-08-25 ZA ZA00755417A patent/ZA755417B/en unknown
- 1975-08-27 GB GB3541975A patent/GB1469745A/en not_active Expired
- 1975-09-02 BE BE159683A patent/BE832999R/en not_active IP Right Cessation
- 1975-09-05 DK DK398675A patent/DK398675A/en unknown
- 1975-09-05 NL NL7510489A patent/NL7510489A/en not_active Application Discontinuation
- 1975-09-05 ES ES440767A patent/ES440767A2/en not_active Expired
- 1975-09-05 SE SE7509884A patent/SE7509884L/en unknown
- 1975-09-06 JP JP50108466A patent/JPS5163153A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL7510489A (en) | 1976-03-09 |
ZA755417B (en) | 1976-07-28 |
FR2283673B1 (en) | 1978-08-18 |
DE2538593A1 (en) | 1976-03-25 |
FR2283673A1 (en) | 1976-04-02 |
DK398675A (en) | 1976-03-07 |
SE7509884L (en) | 1976-03-08 |
AU8428375A (en) | 1977-03-03 |
JPS5163153A (en) | 1976-06-01 |
BE832999R (en) | 1976-03-02 |
DE2538593B2 (en) | 1977-02-03 |
ES440767A2 (en) | 1977-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |