GB1360367A - Derivatives of 4,-aminomethyl-dibenzo-b,e- 11-oxepine-2,- spiro- 1,3, -dioxolane their method of preparation and their thera peutic application - Google Patents

Derivatives of 4,-aminomethyl-dibenzo-b,e- 11-oxepine-2,- spiro- 1,3, -dioxolane their method of preparation and their thera peutic application

Info

Publication number
GB1360367A
GB1360367A GB287973A GB287973A GB1360367A GB 1360367 A GB1360367 A GB 1360367A GB 287973 A GB287973 A GB 287973A GB 287973 A GB287973 A GB 287973A GB 1360367 A GB1360367 A GB 1360367A
Authority
GB
United Kingdom
Prior art keywords
oxepine
dioxolane
spiro
dibenzo
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB287973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Publication of GB1360367A publication Critical patent/GB1360367A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1360367 Alkyl derivatives of 4<SP>1</SP>-aminomethyldibenzo - [b,e] - 11 - oxepine - 2<SP>1</SP> - spiro - 1<SP>1</SP>,3<SP>1</SP>- dioxolane DELALANDE SA 19 Jan 1973 [15 Dec 1972] 2879/73 Addition to 1359951 Heading C2C Alkyl derivatives of 4<SP>1</SP>-aminomethyl-dibenzo- [b,e] - 11 - oxepine - 2<SP>1 </SP>- spiro - 1 1 ,3<SP>1</SP> - dioxolane of formula which R represents an alkyl group having 1 to 4 carbon atoms are claimed per se. These compounds are prepared by condensing, in a benzene medium, 4<SP>1 </SP>- bromomethyl - dibenzo - [b,e]- 11 - oxepine - 2<SP>1</SP>- spiro - 11,31 - dioxolane of formula with a primary amine of formula R-NH 2 in which R has the same significance as in above. The compounds are used as pharmaceuticals.
GB287973A 1972-12-15 1973-01-19 Derivatives of 4,-aminomethyl-dibenzo-b,e- 11-oxepine-2,- spiro- 1,3, -dioxolane their method of preparation and their thera peutic application Expired GB1360367A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7244842A FR2210390B2 (en) 1972-12-15 1972-12-15

Publications (1)

Publication Number Publication Date
GB1360367A true GB1360367A (en) 1974-07-17

Family

ID=9108796

Family Applications (1)

Application Number Title Priority Date Filing Date
GB287973A Expired GB1360367A (en) 1972-12-15 1973-01-19 Derivatives of 4,-aminomethyl-dibenzo-b,e- 11-oxepine-2,- spiro- 1,3, -dioxolane their method of preparation and their thera peutic application

Country Status (13)

Country Link
JP (1) JPS5336476B2 (en)
AU (1) AU467009B2 (en)
BE (1) BE794902A (en)
CA (1) CA985291A (en)
CH (1) CH558793A (en)
ES (1) ES411018A2 (en)
FR (1) FR2210390B2 (en)
GB (1) GB1360367A (en)
IT (1) IT1055523B (en)
LU (1) LU66975A1 (en)
NL (1) NL7301487A (en)
SE (1) SE394890B (en)
ZA (1) ZA73487B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53149771U (en) * 1977-04-28 1978-11-25
JPH0518615Y2 (en) * 1987-10-02 1993-05-18

Also Published As

Publication number Publication date
IT1055523B (en) 1982-01-11
DE2304224A1 (en) 1974-06-20
LU66975A1 (en) 1973-08-17
SE394890B (en) 1977-07-18
NL7301487A (en) 1974-06-18
JPS5336476B2 (en) 1978-10-03
AU467009B2 (en) 1975-11-13
BE794902A (en) 1973-08-02
FR2210390A2 (en) 1974-07-12
ZA73487B (en) 1973-10-31
AU5188873A (en) 1974-08-08
CA985291A (en) 1976-03-09
JPS4987686A (en) 1974-08-22
ES411018A2 (en) 1977-07-01
CH558793A (en) 1975-02-14
FR2210390B2 (en) 1976-07-02
DE2304224B2 (en) 1977-04-21

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee