GB1463077A - 7-substituted-ethyl-cephalosporin derivatives - Google Patents
7-substituted-ethyl-cephalosporin derivativesInfo
- Publication number
- GB1463077A GB1463077A GB1908073A GB1908073A GB1463077A GB 1463077 A GB1463077 A GB 1463077A GB 1908073 A GB1908073 A GB 1908073A GB 1908073 A GB1908073 A GB 1908073A GB 1463077 A GB1463077 A GB 1463077A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- denotes
- thiourea
- substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cephem compounds of the accompanying formula I are prepared. In this formula R<1> denotes a free or protected amino group, preferably an acylamido group; and Y denotes the radical of a thiourea bonded via sulphur, which thiourea can be substituted, or denotes thioamide, thiol or thiophenol. The compounds can additionally carry further substituents in the 2- or 7-position. These compounds are distinguished by an antibiotic activity and can be employed in human and veterinary medicine. Of these compounds, those in which R<1> denotes an acylamido group and Y corresponds to a pyrid-2-ylthio radical are preferred on account of their activity against a multiplicity of Gram-positive and Gram-negative organisms. The compounds of the formula I are prepared by reaction of the corresponding 3-vinyl compound with a thiourea, substituted thiourea, thioamide, thiol or thiophenol. <IMAGE>
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1908073A GB1463077A (en) | 1973-04-19 | 1973-04-19 | 7-substituted-ethyl-cephalosporin derivatives |
IE84174A IE39373B1 (en) | 1973-04-19 | 1974-04-18 | 3-substituted ethyl-cephalosporin compounds |
BE143354A BE813892A (en) | 1973-04-19 | 1974-04-18 | PROCESS FOR TRANSFORMATION OF CEPHALOSPORINIC COMPOUNDS AND PRODUCTS THUS OBTAINED |
CH539074A CH615186A5 (en) | 1973-04-19 | 1974-04-18 | Process for the preparation of cephem compounds |
LU69884A LU69884A1 (en) | 1973-04-19 | 1974-04-18 | |
NL7405257A NL7405257A (en) | 1973-04-19 | 1974-04-18 | |
DE19742418768 DE2418768A1 (en) | 1973-04-19 | 1974-04-18 | IMPROVED PROCESS FOR PREPARING CEPHALOSPORIN COMPOUNDS AND THE PRODUCTS OBTAINED THEREOF |
JP4385274A JPS5030900A (en) | 1973-04-19 | 1974-04-18 | |
FR7413830A FR2226406B1 (en) | 1973-04-19 | 1974-04-19 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1908073A GB1463077A (en) | 1973-04-19 | 1973-04-19 | 7-substituted-ethyl-cephalosporin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1463077A true GB1463077A (en) | 1977-02-02 |
Family
ID=10123445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1908073A Expired GB1463077A (en) | 1973-04-19 | 1973-04-19 | 7-substituted-ethyl-cephalosporin derivatives |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS5030900A (en) |
BE (1) | BE813892A (en) |
CH (1) | CH615186A5 (en) |
DE (1) | DE2418768A1 (en) |
FR (1) | FR2226406B1 (en) |
GB (1) | GB1463077A (en) |
IE (1) | IE39373B1 (en) |
LU (1) | LU69884A1 (en) |
NL (1) | NL7405257A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4954253U (en) * | 1972-08-22 | 1974-05-14 | ||
FR2457296A1 (en) * | 1979-05-23 | 1980-12-19 | Rhone Poulenc Ind | NOVEL VINYL-3 CEPHALOSPORINS DERIVATIVES AND THEIR PREPARATION |
US4342758A (en) | 1979-08-15 | 1982-08-03 | Merck & Co., Inc. | Allylsulfoxide enzyme inhibitors |
PT71651B (en) * | 1979-08-15 | 1982-01-21 | Merck & Co Inc | Process for preparing allysulfoxide enzyme inhibitors |
-
1973
- 1973-04-19 GB GB1908073A patent/GB1463077A/en not_active Expired
-
1974
- 1974-04-18 LU LU69884A patent/LU69884A1/xx unknown
- 1974-04-18 BE BE143354A patent/BE813892A/en not_active IP Right Cessation
- 1974-04-18 IE IE84174A patent/IE39373B1/en unknown
- 1974-04-18 DE DE19742418768 patent/DE2418768A1/en not_active Withdrawn
- 1974-04-18 JP JP4385274A patent/JPS5030900A/ja active Pending
- 1974-04-18 NL NL7405257A patent/NL7405257A/xx unknown
- 1974-04-18 CH CH539074A patent/CH615186A5/en not_active IP Right Cessation
- 1974-04-19 FR FR7413830A patent/FR2226406B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2226406B1 (en) | 1978-08-11 |
LU69884A1 (en) | 1974-07-18 |
CH615186A5 (en) | 1980-01-15 |
IE39373B1 (en) | 1978-09-27 |
DE2418768A1 (en) | 1974-10-31 |
BE813892A (en) | 1974-10-18 |
NL7405257A (en) | 1974-10-22 |
IE39373L (en) | 1974-10-19 |
JPS5030900A (en) | 1975-03-27 |
FR2226406A1 (en) | 1974-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB2000138A (en) | Therapeutic agents | |
ZA861713B (en) | B-lactam antibiotics,process for their preparation and their use as and in medicaments | |
SE7611047L (en) | PROCEDURE FOR PREPARING ANTIBACTERIAL SUBJECT | |
ES426003A1 (en) | {60 -amino-{60 -(ureidophenyl)acetamidocephalosporins | |
GB1463077A (en) | 7-substituted-ethyl-cephalosporin derivatives | |
SE7411243L (en) | ||
GB1521073A (en) | Cephalosporin compounds | |
SE8104771L (en) | cephalosporin derivatives | |
GB1531141A (en) | Beta-lactam antibiotics | |
ES471769A1 (en) | Penicillins, process for their preparation and their use. | |
ES453508A1 (en) | Desacetyl antibiatics 890a1 and 890a3 | |
FI833839A0 (en) | FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT AKTIVA KEFALOSPORINDERIVAT | |
SE7712645L (en) | MONOCYCLIC BETA LACTAMS WITH ANTIBACTERIAL ACTIVITY | |
SE7600397L (en) | PROCEDURE FOR PREPARING PENICILLINES | |
ES431943A1 (en) | Cephalosporin derivatives | |
GB1028563A (en) | Antibacterial derivative of 7-aminocephalosporanic acid | |
ES8200371A1 (en) | N-substituted thiazolyl derivatives of oxy-imino-substituted cephalosporins useful as anti-bacterial agents | |
FR2242986B1 (en) | ||
SE7707366L (en) | PROCEDURE FOR THE PREPARATION OF 7ALFA-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES | |
ES423024A1 (en) | Novel acid compounds | |
GB1539053A (en) | Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins | |
GB1533413A (en) | Penicillins | |
SE7702370L (en) | TIENAMYCIN DERIVATIVES | |
GB953696A (en) | Improvements in and relating to antibiotics | |
ES452769A1 (en) | Cephalosporins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |