GB1452413A - - Google Patents

Info

Publication number
GB1452413A
GB1452413A GB3288874A GB3288874A GB1452413A GB 1452413 A GB1452413 A GB 1452413A GB 3288874 A GB3288874 A GB 3288874A GB 3288874 A GB3288874 A GB 3288874A GB 1452413 A GB1452413 A GB 1452413A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
formula
lower alkyl
compounds
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3288874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuji Chemical Industries Co Ltd
Nippon Chemiphar Co Ltd
Original Assignee
Fuji Chemical Industries Co Ltd
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP48091318A external-priority patent/JPS5041878A/ja
Priority claimed from JP48092096A external-priority patent/JPS5046677A/ja
Priority claimed from JP48092097A external-priority patent/JPS5046678A/ja
Priority claimed from JP49080727A external-priority patent/JPS518284A/en
Priority claimed from JP49080729A external-priority patent/JPS518286A/en
Priority claimed from JP49080728A external-priority patent/JPS518285A/en
Application filed by Fuji Chemical Industries Co Ltd, Nippon Chemiphar Co Ltd filed Critical Fuji Chemical Industries Co Ltd
Publication of GB1452413A publication Critical patent/GB1452413A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1452413 N-(α-Cyanobenzyl) piperazines and homopiperazines FUJI CHEMICAL INDUSTRY CO Ltd and NIPPON CHEMIPHAR CO Ltd 25 July 1974 [18 Aug 1973 (2) 16 July 1974 (3) 16 Aug 1973] 32888/74 Heading C2C The invention comprises compounds of general formula and acid additive salts thereof, where R 1 is halogen or lower alkoxy, R 2 and R 3 are hydrogen or lower alkoxy, R 4 is hydrogen or lower alkyl, R 5 is hydrogen, -COOR 6 (R 6 is lower alkyl) (R 7 is lower alkoxy and m is 0, 1, 2 or 3), -R 8 COOR 9 (R 8 is lower alkylene and R 9 is lower alkyl) -CH 2 CONR 10 R 11 (R 10 and R 11 are hydrogen or lower alkyl or jointly form an alkylene group) or where n is 2 or 3; "lower" here means containing up to 3 carbon atoms. These compounds are prepared (a) by reacting an aromatic aldehyde or ketones of formula with a piperazine or homopiperazine of formula or an acid addition salt thereof, in the presence of hydrogen cyanide or a salt thereof, or (b) by reacting a compound of formula or an acid addition salt thereof with a compound R 5 X where X is a halogen atom. The compounds of the invention have activity as antianginal drugs.
GB3288874A 1973-08-16 1974-07-25 Expired GB1452413A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP48091318A JPS5041878A (en) 1973-08-16 1973-08-16
JP48092096A JPS5046677A (en) 1973-08-18 1973-08-18
JP48092097A JPS5046678A (en) 1973-08-18 1973-08-18
JP49080727A JPS518284A (en) 1974-07-16 1974-07-16 Shinkinaarufua shianobenjirupiperajinjudotaino seizoho
JP49080729A JPS518286A (en) 1974-07-16 1974-07-16 Shinkinabisu * arufua shianobenjiru * piperajinruinoseizoho
JP49080728A JPS518285A (en) 1974-07-16 1974-07-16 Arufua shianobenjirupiperajinjudotaino seizoho

Publications (1)

Publication Number Publication Date
GB1452413A true GB1452413A (en) 1976-10-13

Family

ID=27551498

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3288874A Expired GB1452413A (en) 1973-08-16 1974-07-25

Country Status (4)

Country Link
CH (1) CH592074A5 (en)
DE (1) DE2439461A1 (en)
FR (1) FR2240729B1 (en)
GB (1) GB1452413A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016516A1 (en) * 1991-03-15 1992-10-01 Basf Aktiengesellschaft New 1-aryl-4-piperazinyl-cyclohexanecarboxylic acid nitriles, their production and their use
EP0710482A3 (en) * 1994-11-02 1996-05-22 Kowa Co

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS632986A (en) * 1986-06-23 1988-01-07 Kanebo Ltd Novel piperazine derivative and antiulcer agent containing said compound as active ingredient

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016516A1 (en) * 1991-03-15 1992-10-01 Basf Aktiengesellschaft New 1-aryl-4-piperazinyl-cyclohexanecarboxylic acid nitriles, their production and their use
US5371088A (en) * 1991-03-15 1994-12-06 Basf Aktiengesellschaft 1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use thereof
EP0710482A3 (en) * 1994-11-02 1996-05-22 Kowa Co
US5602123A (en) * 1994-11-02 1997-02-11 Kowa Co., Ltd. Therapeutic agent for myocardial ischemic damages or reperfusion

Also Published As

Publication number Publication date
FR2240729A1 (en) 1975-03-14
DE2439461A1 (en) 1975-02-27
CH592074A5 (en) 1977-10-14
FR2240729B1 (en) 1978-07-21

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee