GB1449934A - Oxamic acid derivatives - Google Patents
Oxamic acid derivativesInfo
- Publication number
- GB1449934A GB1449934A GB1140974A GB1140974A GB1449934A GB 1449934 A GB1449934 A GB 1449934A GB 1140974 A GB1140974 A GB 1140974A GB 1140974 A GB1140974 A GB 1140974A GB 1449934 A GB1449934 A GB 1449934A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- group
- cor
- pyridyl
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1449934 Oxamic acid derivatives AMERICAN HOME PRODUCTS CORP 14 March 1974 [23 March 1973 7 Aug 1973] 11409/74 Heading C2C The invention comprises oxamic acid derivatives of the formulµ in which A<SP>1</SP> is 2-cyanophenyl, 3-fluorophenyl, 4-phenylazophenyl, 4-carbamoylphenyl, 2- nitro - 4 - trifluoromethylphenyl, 2 - cyano - 3- methoxyphenyl 4 - nitro - 3 - trifluoromethylphenyl, 5-chloro-2-sulphamoylphenyl or a radical of the formula wherein R is OH, C 1-6 alkoxy, cyclohexyloxy or NH 2 , R<SP>2</SP> is H, C 1-6 alkoxy, halogen or phenoxy- C 1-6 alkoxy; R<SP>3</SP> is H, C 1-6 alkoxy, halogen or NO 2 ; and R<SP>4</SP> H or C 1-4 alkoxy; with the proviso that at least one of R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> is other than H; A<SP>2</SP> is 3-pyridyl, 4-pyridyl, 2-pyrazinyl or 2-pyrimidinyl, and R<SP>5</SP> is C 1-6 alkoxy, or A<SP>2</SP> is 2-pyridyl and R<SP>5</SP> is OCH 3 , cyclohexyloxy or C 3-6 alkoxy; and their preparation by reacting amines of the formulµ or reactive derivatives thereof with oxalic acids derivatives of the formula or reactive derivatives thereof, in which X is COR, where R is OH, C 1-6 alkoxy or NH 2 or a precursor of the group COR, and if required converting the group X in the products to the desired group COR or COR<SP>5</SP> by known methods or converting one group A<SP>1</SP> in the product into another group A<SP>1</SP> by known methods. 2 - Amino - 6 - (2 - phenoxyethoxy)benzamide is prepared by reducing and hydrolysing 2-nitro- 6 - (2 - phenoxyethoxy)benronitrile, obtained by reacting 2-phenoxyethanol with 2,6-dinitrobenzonitrile in the presence of sodium methylsulphinylmethylide. 2 - Amino - 4 - methoxybenzamide is prepared by reducing and hydrolysing 2-amino-4-methoxybenzonitrile.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB844776A GB1449936A (en) | 1973-03-23 | 1974-03-14 | Pharmaceutical compositions containing tetrazole derivatives and use of the derivatives in suppressing allergic mani festations |
GB4484175A GB1449935A (en) | 1973-03-23 | 1974-03-14 | Pharmaceutical compositions containing oxamic acid derivatives and use of the derivatives suppressing allergic manifestations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34446673A | 1973-03-23 | 1973-03-23 | |
IE134673 | 1973-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1449934A true GB1449934A (en) | 1976-09-15 |
Family
ID=26319091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1140974A Expired GB1449934A (en) | 1973-03-23 | 1974-03-14 | Oxamic acid derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1449934A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230484A (en) * | 1977-05-05 | 1980-10-28 | Imperial Chemical Industries Limited | Control of pollen formation |
WO1999046236A1 (en) * | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
US6225329B1 (en) | 1998-03-12 | 2001-05-01 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPases) |
-
1974
- 1974-03-14 GB GB1140974A patent/GB1449934A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4230484A (en) * | 1977-05-05 | 1980-10-28 | Imperial Chemical Industries Limited | Control of pollen formation |
WO1999046236A1 (en) * | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
US6225329B1 (en) | 1998-03-12 | 2001-05-01 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPases) |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |