GB1415333A - Insulin derivatives - Google Patents
Insulin derivativesInfo
- Publication number
- GB1415333A GB1415333A GB5466372A GB5466372A GB1415333A GB 1415333 A GB1415333 A GB 1415333A GB 5466372 A GB5466372 A GB 5466372A GB 5466372 A GB5466372 A GB 5466372A GB 1415333 A GB1415333 A GB 1415333A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- carbamoyl
- phe
- gly
- nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
1415333 Insulin derivatives SCHERING AG 27 Nov 1972 [27 Nov 1971] 54663/72 Heading C3H Novel (N<SP>α</SP> - carbamoyl - phe)B 1 - insulin, (N<SP>α</SP> - carbamoyl - gly)A 1 - (N<SP>α</SP> - carbamoylphe)B 1 - insulin and (N<SP>α</SP> - carbamoyl - gly)A 1 - (N<SP>α</SP> - carbamoyl - phe)B 1 - (N<SP>#</SP> - carbamoyllys)B 29 - insulin are prepared by carbamoylation of insulin at a controlled pH value, using, e.g. an alkali metal or ammonium cyanate. Pharmaceutical compositions for use in treating diabetes in insulin-resistant patients comprise one of the above novel insulin derivatives together with a suitable diluent or carrier and are preferably administered parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712159579 DE2159579A1 (en) | 1971-11-27 | 1971-11-27 | INSULINE DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1415333A true GB1415333A (en) | 1975-11-26 |
Family
ID=5826712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5466372A Expired GB1415333A (en) | 1971-11-27 | 1972-11-27 | Insulin derivatives |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS4857990A (en) |
BE (1) | BE791949A (en) |
DE (1) | DE2159579A1 (en) |
FR (1) | FR2161063B1 (en) |
GB (1) | GB1415333A (en) |
NL (1) | NL7216078A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE36225B1 (en) * | 1971-01-28 | 1976-09-15 | Nat Res Dev | Improvements relating to insulin derivatives |
-
0
- BE BE791949D patent/BE791949A/en unknown
-
1971
- 1971-11-27 DE DE19712159579 patent/DE2159579A1/en active Pending
-
1972
- 1972-11-24 FR FR7241860A patent/FR2161063B1/fr not_active Expired
- 1972-11-27 NL NL7216078A patent/NL7216078A/xx unknown
- 1972-11-27 GB GB5466372A patent/GB1415333A/en not_active Expired
- 1972-11-27 JP JP11882372A patent/JPS4857990A/ja active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5922675A (en) * | 1994-11-17 | 1999-07-13 | Eli Lilly And Company | Acylated Insulin Analogs |
USRE37971E1 (en) | 1994-11-17 | 2003-01-28 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
Also Published As
Publication number | Publication date |
---|---|
DE2159579A1 (en) | 1973-06-07 |
NL7216078A (en) | 1973-05-29 |
FR2161063A1 (en) | 1973-07-06 |
BE791949A (en) | 1973-05-28 |
JPS4857990A (en) | 1973-08-14 |
FR2161063B1 (en) | 1975-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
48R | Reference inserted (sect. 8/1949) | ||
PLNP | Patent lapsed through nonpayment of renewal fees |