IE36225B1 - Improvements relating to insulin derivatives - Google Patents

Improvements relating to insulin derivatives

Info

Publication number
IE36225B1
IE36225B1 IE4672A IE4672A IE36225B1 IE 36225 B1 IE36225 B1 IE 36225B1 IE 4672 A IE4672 A IE 4672A IE 4672 A IE4672 A IE 4672A IE 36225 B1 IE36225 B1 IE 36225B1
Authority
IE
Ireland
Prior art keywords
blocked
gps
prepns
derivs
pref
Prior art date
Application number
IE4672A
Other versions
IE36225L (en
Original Assignee
Nat Res Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB338771A external-priority patent/GB1381273A/en
Priority claimed from GB338871A external-priority patent/GB1381274A/en
Application filed by Nat Res Dev filed Critical Nat Res Dev
Publication of IE36225L publication Critical patent/IE36225L/en
Publication of IE36225B1 publication Critical patent/IE36225B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Therepeutic prepns. contg. insulin derivs., in which at least one of the NH2 gps. of the A1(glycine), B1 (phenylalanine) and B29 (lysine) amino acid elements is blocked by a substituent capable of forming an anion, and in which opt. at least one tyrosine OH gp. is blocked by a substit. easily removable in vivo, have a large proportion of the hypoglycaemic activity of normal insulin prepns. while being more sol. in H2O and having acceptable immunological properties. The OH-blocked cpds. extend the duration of hypoglycaemic activity. Pref. N-blocking gps. are succinyl and glutaryl, and OH-blocking gps. are pref. opt. N-substd. carbamoyl. The N-blocked derivs. may be prepd. by acylation with a suitable dicarboxylic acid or functional deriv. [FR2123524A1]
IE4672A 1971-01-28 1972-01-12 Improvements relating to insulin derivatives IE36225B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB338771A GB1381273A (en) 1971-01-28 1971-01-28 Insulin derivatives
GB338871A GB1381274A (en) 1971-01-28 1971-01-28 Insulin derivatives

Publications (2)

Publication Number Publication Date
IE36225L IE36225L (en) 1972-07-28
IE36225B1 true IE36225B1 (en) 1976-09-15

Family

ID=26238276

Family Applications (1)

Application Number Title Priority Date Filing Date
IE4672A IE36225B1 (en) 1971-01-28 1972-01-12 Improvements relating to insulin derivatives

Country Status (8)

Country Link
AU (1) AU472582B2 (en)
BE (1) BE778538A (en)
CH (1) CH547777A (en)
DE (1) DE2204053A1 (en)
FR (1) FR2123524A1 (en)
IE (1) IE36225B1 (en)
NL (1) NL7201179A (en)
SE (1) SE382452B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309123B2 (en) 2007-12-19 2012-11-13 Farid Bennis Pharmaceutical compositions and methods for the oral delivery of insulin

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791585A (en) * 1971-11-18 1973-05-17 Nat Res Dev INSULIN DERIVATIVES
BE791949A (en) * 1971-11-27 1973-05-28 Schering Ag INSULIN DERIVATIVES, THEIR PREPARATION AND USE
US3847893A (en) * 1972-03-01 1974-11-12 Bayer Ag Process for the preparation of insulin derivatives cross-linked by a dicarboxylic acid group at the amino a-1 glycine and amino b-29 lysine
US3907763A (en) * 1972-03-01 1975-09-23 Bayer Ag Insulin derivatives crosslinked by a dicarboxylic acid moiety
DE2252157C3 (en) * 1972-10-25 1976-03-18 Hoechst Ag INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF INSULIN, INSULIN ANALOGS AND DERIVATIVES AND PROCESSES FOR THE MANUFACTURING OF INSULIN, INSULIN ANALOGS AND DERIVATIVES
DE2253327A1 (en) * 1972-10-31 1974-05-09 Hoechst Ag PROCESS FOR THE MANUFACTURING OF INSULIN, INSULIN ANALOGS AND DERIVATIVES
NL7314766A (en) * 1972-10-31 1974-05-02
GB1560933A (en) * 1975-04-15 1980-02-13 Wellcome Found Biologically activy polypeptides
US4175122A (en) * 1975-04-15 1979-11-20 Burroughs Wellcome Co. Biologically active amides
US4223017A (en) * 1975-04-15 1980-09-16 Burroughs Wellcome Co. Biologically active amides
DK179286D0 (en) * 1986-04-18 1986-04-18 Nordisk Gentofte INSULIN PREPARATION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309123B2 (en) 2007-12-19 2012-11-13 Farid Bennis Pharmaceutical compositions and methods for the oral delivery of insulin

Also Published As

Publication number Publication date
AU472582B2 (en) 1976-05-27
DE2204053A1 (en) 1972-08-17
SE382452B (en) 1976-02-02
FR2123524A1 (en) 1972-09-08
BE778538A (en) 1972-07-26
IE36225L (en) 1972-07-28
AU3821372A (en) 1973-07-26
CH547777A (en) 1974-04-11
FR2123524B1 (en) 1975-12-26
NL7201179A (en) 1972-08-01

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