GB1413831A - Prostatrienoic acid derivatives and process - Google Patents

Prostatrienoic acid derivatives and process

Info

Publication number
GB1413831A
GB1413831A GB5571373A GB5571373A GB1413831A GB 1413831 A GB1413831 A GB 1413831A GB 5571373 A GB5571373 A GB 5571373A GB 5571373 A GB5571373 A GB 5571373A GB 1413831 A GB1413831 A GB 1413831A
Authority
GB
United Kingdom
Prior art keywords
trienoate
trimethylsilyloxy
trans
racemic methyl
oxoprosta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5571373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of GB1413831A publication Critical patent/GB1413831A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1413831 Silylated prostatrienoates SYNTEX CORP 1 Dec 1972 [3 Dec 1971 14 Nov 1972] 55713/72 Heading C3S [Also in Division C2] Racemic methyl 9α,11α-bis-(trimethylsilyloxy) - 15# - hydroxy - 15# - methylprosta- 4,5,13 - trans - trienoate is prepared by reacting methyl lithium with racemic methyl 9α,11α - bis - (trimethylsilyloxy) - 15 - oxoprosta - 4,5,13 - trans - trienoate, resulting from the treatment of racemic methyl 9α,11α- dihydroxy - 15 - oxoprosta - 4,5,13 - transtrienoate with hexamethyldisilazane and trimethylchlorosilane. By a similar procedure 1 racemic methyl 9-trimethylsilyloxyimino- 11α - trimethylsilyloxy - 15# - hydroxy - 15#- methylprota - 4,5,13 - trans - trienoate, and racemic methyl 9-trimethylsilyloxyimino-11α- trimethylsilyloxy - 15 - oxoprosta - 4,5,13- trans-trienoate are obtained.
GB5571373A 1971-12-03 1972-12-01 Prostatrienoic acid derivatives and process Expired GB1413831A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20476971A 1971-12-03 1971-12-03
US30641472A 1972-11-14 1972-11-14

Publications (1)

Publication Number Publication Date
GB1413831A true GB1413831A (en) 1975-11-12

Family

ID=26899786

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5571373A Expired GB1413831A (en) 1971-12-03 1972-12-01 Prostatrienoic acid derivatives and process

Country Status (8)

Country Link
JP (1) JPS4864053A (en)
CH (3) CH594623A5 (en)
DE (1) DE2258668C3 (en)
ES (1) ES409251A1 (en)
GB (1) GB1413831A (en)
HK (1) HK75176A (en)
MY (1) MY7700076A (en)
NL (1) NL7216377A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873598A (en) * 1973-07-06 1975-03-25 Syntex Inc 4,5,10,13 prostatetraenoic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754114A (en) * 1969-07-29 1971-01-29 Upjohn Co NEW COMPOUNDS OF THE PROSTAGLANDIN CLASS AND THEIR PREPARATION PROCESS
CA927392A (en) * 1970-03-09 1973-05-29 Philip F. Beal, Iii Cyclopentane derivatives
CA959485A (en) * 1970-05-04 1974-12-17 Gordon L. Bundy 15-alkyl prostaglandins

Also Published As

Publication number Publication date
CH590836A5 (en) 1977-08-31
JPS4864053A (en) 1973-09-05
MY7700076A (en) 1977-12-31
HK75176A (en) 1976-12-10
DE2258668C3 (en) 1981-08-06
CH589620A5 (en) 1977-07-15
ES409251A1 (en) 1976-05-16
DE2258668A1 (en) 1973-08-02
NL7216377A (en) 1973-06-05
CH594623A5 (en) 1978-01-13
DE2258668B2 (en) 1980-11-27

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Legal Events

Date Code Title Description
PS Patent sealed
PLE Entries relating assignments, transmissions, licences in the register of patents
PCNP Patent ceased through non-payment of renewal fee