GB1413831A - Prostatrienoic acid derivatives and process - Google Patents
Prostatrienoic acid derivatives and processInfo
- Publication number
- GB1413831A GB1413831A GB5571373A GB5571373A GB1413831A GB 1413831 A GB1413831 A GB 1413831A GB 5571373 A GB5571373 A GB 5571373A GB 5571373 A GB5571373 A GB 5571373A GB 1413831 A GB1413831 A GB 1413831A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trienoate
- trimethylsilyloxy
- trans
- racemic methyl
- oxoprosta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 abstract 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 abstract 2
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005051 trimethylchlorosilane Substances 0.000 abstract 1
- -1 trimethylsilyloxy Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1413831 Silylated prostatrienoates SYNTEX CORP 1 Dec 1972 [3 Dec 1971 14 Nov 1972] 55713/72 Heading C3S [Also in Division C2] Racemic methyl 9α,11α-bis-(trimethylsilyloxy) - 15# - hydroxy - 15# - methylprosta- 4,5,13 - trans - trienoate is prepared by reacting methyl lithium with racemic methyl 9α,11α - bis - (trimethylsilyloxy) - 15 - oxoprosta - 4,5,13 - trans - trienoate, resulting from the treatment of racemic methyl 9α,11α- dihydroxy - 15 - oxoprosta - 4,5,13 - transtrienoate with hexamethyldisilazane and trimethylchlorosilane. By a similar procedure 1 racemic methyl 9-trimethylsilyloxyimino- 11α - trimethylsilyloxy - 15# - hydroxy - 15#- methylprota - 4,5,13 - trans - trienoate, and racemic methyl 9-trimethylsilyloxyimino-11α- trimethylsilyloxy - 15 - oxoprosta - 4,5,13- trans-trienoate are obtained.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20476971A | 1971-12-03 | 1971-12-03 | |
US30641472A | 1972-11-14 | 1972-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1413831A true GB1413831A (en) | 1975-11-12 |
Family
ID=26899786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5571373A Expired GB1413831A (en) | 1971-12-03 | 1972-12-01 | Prostatrienoic acid derivatives and process |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS4864053A (en) |
CH (3) | CH594623A5 (en) |
DE (1) | DE2258668C3 (en) |
ES (1) | ES409251A1 (en) |
GB (1) | GB1413831A (en) |
HK (1) | HK75176A (en) |
MY (1) | MY7700076A (en) |
NL (1) | NL7216377A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3873598A (en) * | 1973-07-06 | 1975-03-25 | Syntex Inc | 4,5,10,13 prostatetraenoic acid derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754114A (en) * | 1969-07-29 | 1971-01-29 | Upjohn Co | NEW COMPOUNDS OF THE PROSTAGLANDIN CLASS AND THEIR PREPARATION PROCESS |
CA927392A (en) * | 1970-03-09 | 1973-05-29 | Philip F. Beal, Iii | Cyclopentane derivatives |
CA959485A (en) * | 1970-05-04 | 1974-12-17 | Gordon L. Bundy | 15-alkyl prostaglandins |
-
1972
- 1972-11-30 DE DE19722258668 patent/DE2258668C3/en not_active Expired
- 1972-12-01 CH CH1000676A patent/CH594623A5/xx not_active IP Right Cessation
- 1972-12-01 GB GB5571373A patent/GB1413831A/en not_active Expired
- 1972-12-01 NL NL7216377A patent/NL7216377A/xx not_active Application Discontinuation
- 1972-12-01 CH CH1754772A patent/CH589620A5/xx not_active IP Right Cessation
- 1972-12-02 ES ES409251A patent/ES409251A1/en not_active Expired
- 1972-12-04 JP JP12144472A patent/JPS4864053A/ja active Pending
-
1976
- 1976-12-02 HK HK75176A patent/HK75176A/en unknown
-
1977
- 1977-01-04 CH CH1754772A patent/CH590836A5/xx not_active IP Right Cessation
- 1977-12-30 MY MY7700076A patent/MY7700076A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CH590836A5 (en) | 1977-08-31 |
JPS4864053A (en) | 1973-09-05 |
MY7700076A (en) | 1977-12-31 |
HK75176A (en) | 1976-12-10 |
DE2258668C3 (en) | 1981-08-06 |
CH589620A5 (en) | 1977-07-15 |
ES409251A1 (en) | 1976-05-16 |
DE2258668A1 (en) | 1973-08-02 |
NL7216377A (en) | 1973-06-05 |
CH594623A5 (en) | 1978-01-13 |
DE2258668B2 (en) | 1980-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLE | Entries relating assignments, transmissions, licences in the register of patents | ||
PCNP | Patent ceased through non-payment of renewal fee |