GB1400999A - Imidazo-triazine compounds and their use in therapeutic compositions - Google Patents

Imidazo-triazine compounds and their use in therapeutic compositions

Info

Publication number
GB1400999A
GB1400999A GB5375071A GB5375071A GB1400999A GB 1400999 A GB1400999 A GB 1400999A GB 5375071 A GB5375071 A GB 5375071A GB 5375071 A GB5375071 A GB 5375071A GB 1400999 A GB1400999 A GB 1400999A
Authority
GB
United Kingdom
Prior art keywords
imidazo
aerosol
group
therapeutic compositions
triazine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5375071A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE791025D priority Critical patent/BE791025A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB5375071A priority patent/GB1400999A/en
Priority to ZA727532A priority patent/ZA727532B/en
Priority to DK525172AA priority patent/DK138691B/en
Priority to IE1433/72A priority patent/IE37046B1/en
Priority to US00300749A priority patent/US3840537A/en
Priority to AU48191/72A priority patent/AU472127B2/en
Priority to IL40686A priority patent/IL40686A/en
Priority to CA155,720A priority patent/CA990292A/en
Priority to SE7214358A priority patent/SE402915B/en
Priority to FR7239498A priority patent/FR2160407B1/fr
Priority to DE2255172A priority patent/DE2255172A1/en
Priority to PH14090*UA priority patent/PH9669A/en
Priority to CH1668372A priority patent/CH594671A5/xx
Priority to JP11549572A priority patent/JPS563873B2/ja
Priority to ES408736A priority patent/ES408736A1/en
Priority to AT982372A priority patent/AT321923B/en
Priority to NL7215646A priority patent/NL7215646A/xx
Publication of GB1400999A publication Critical patent/GB1400999A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1400999 Pharmaceutical aerosol composition ALLEN & HANBURYS Ltd 23 Oct 1972 [19 Nov 1971] 53750/71 Heading C4X [Also in Divisions A5 and C2] Compounds of the general Formula I and physiologically acceptable addition salts thereof, in which R 1 , R 2 , R 4 and R 5 each represents a hydrogen atom, or a C 1 -C 6 alkyl or C 2 -C 6 alkenyl group optionally substituted by one or more aryl groups, R 3 represents hydrogen or a C 1 -C 6 alkyl group, and R 1 may additionally represent a C 1 -C 6 acyl group and R 4 and R 5 may additionally represent a cycloalkyl or aryl group are used in pharmaceutical compositions which may be prepared in the form of an aerosol spray. An example describes the preparation of an inhalation aerosol from 2- amino - 5 - methyl - 7 - propyl - imidazo[5,1- f]-cis-triazine-4(3H)-one, sorbitan trioleate, trichlorofluoromethane and dichlorodifluoromethane (Ex. 12).
GB5375071A 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions Expired GB1400999A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
BE791025D BE791025A (en) 1971-11-19 HETEROCYCLIC COMPOUNDS
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions
ZA727532A ZA727532B (en) 1971-11-19 1972-10-23 Heterocyclic compounds
DK525172AA DK138691B (en) 1971-11-19 1972-10-23 Analogous process for the preparation of imidazo (5,1-f) triazinones or their salts.
IE1433/72A IE37046B1 (en) 1971-11-19 1972-10-23 Imidazo-triazine compounds and their use in therapeutic compositions
US00300749A US3840537A (en) 1971-11-19 1972-10-25 Imidazo(5,1-f)triazinones
AU48191/72A AU472127B2 (en) 1971-11-19 1972-10-26 Heterocyclic compounds
IL40686A IL40686A (en) 1971-11-19 1972-10-27 2-amino-imidazo(5,1-f)-as-triazin-4(3h)-ones,their preparation and pharmaceutical compositions containing them
CA155,720A CA990292A (en) 1971-11-19 1972-11-01 Imidazo-triazinones
SE7214358A SE402915B (en) 1971-11-19 1972-11-06 PROCEDURE FOR THE PREPARATION OF IMIDAZO (5,1-F) TRIAZINONES WITH THERAPEUTIC EFFECT
FR7239498A FR2160407B1 (en) 1971-11-19 1972-11-08
DE2255172A DE2255172A1 (en) 1971-11-19 1972-11-10 IMIDAZOTRIAZINONE, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS
PH14090*UA PH9669A (en) 1971-11-19 1972-11-16 Imidazo-(5,1-f)-as-triazin-4(3h)-ones,their compositions and method of use
CH1668372A CH594671A5 (en) 1971-11-19 1972-11-16
JP11549572A JPS563873B2 (en) 1971-11-19 1972-11-17
ES408736A ES408736A1 (en) 1971-11-19 1972-11-17 Imidazo(5,1-f)triazinones
AT982372A AT321923B (en) 1971-11-19 1972-11-17 PROCESS FOR PRODUCING NEW IMIDAZOTRIAZINONES
NL7215646A NL7215646A (en) 1971-11-19 1972-11-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5375071A GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Publications (1)

Publication Number Publication Date
GB1400999A true GB1400999A (en) 1975-07-16

Family

ID=10468856

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5375071A Expired GB1400999A (en) 1971-11-19 1971-11-19 Imidazo-triazine compounds and their use in therapeutic compositions

Country Status (18)

Country Link
US (1) US3840537A (en)
JP (1) JPS563873B2 (en)
AT (1) AT321923B (en)
AU (1) AU472127B2 (en)
BE (1) BE791025A (en)
CA (1) CA990292A (en)
CH (1) CH594671A5 (en)
DE (1) DE2255172A1 (en)
DK (1) DK138691B (en)
ES (1) ES408736A1 (en)
FR (1) FR2160407B1 (en)
GB (1) GB1400999A (en)
IE (1) IE37046B1 (en)
IL (1) IL40686A (en)
NL (1) NL7215646A (en)
PH (1) PH9669A (en)
SE (1) SE402915B (en)
ZA (1) ZA727532B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0009384A1 (en) * 1978-09-18 1980-04-02 Glaxo Group Limited Processes for the preparation of triazinones and condensed triazinones, and compounds so obtained
US4278673A (en) * 1977-03-25 1981-07-14 Allen & Hanburys Limited Pharmacologically active compounds
US5498774A (en) * 1989-06-23 1996-03-12 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO2016147659A1 (en) * 2015-03-16 2016-09-22 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457873A (en) * 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
DE2314488C3 (en) * 1973-03-23 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 8- (2,6-Dichlorophenyl) -7- (4-chlorophenyl) -5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazine, process for its preparation and medicament containing it
DE2335193A1 (en) * 1973-07-11 1975-01-30 Hoechst Ag BIS-TRIAZINOBENZIMIDAZOLE AND THEIR PRODUCTION
US4115572A (en) * 1977-02-03 1978-09-19 American Cyanamid Company Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
USRE30511E (en) * 1977-02-03 1981-02-10 American Cyanamid Company Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
US4107307A (en) * 1977-02-03 1978-08-15 American Cyanamid Company Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
US4107308A (en) * 1977-10-18 1978-08-15 American Cyanamid Company Imidazo[1,5-d]-as-triazines
HU187474B (en) * 1981-11-18 1986-01-28 Gyogyszerkutato Intezet,Hu Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) * 1982-02-10 1983-07-26 American Cyanamid Co. Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
DE59803108D1 (en) * 1997-11-12 2002-03-21 Bayer Ag 2-PHENYL-SUBSTITUTED IMIDAZOTRIAZINONE AS PHOSPHODIESTERASE INHIBITORS
DE19827640A1 (en) * 1998-06-20 1999-12-23 Bayer Ag New imidazotriazine derivatives useful as smooth muscle relaxants for treating e.g. cardiovascular disorders, cerebrovascular disorders, or erectile dysfunction
PL346271A1 (en) 1998-08-26 2002-01-28 Smithkline Beecham Corp Therapies for treating pulmonary diseases
JP5038568B2 (en) * 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Combination of synergists
MXPA03010119A (en) * 2001-05-09 2005-03-07 Bayer Healthcare Ag Novel use of 2-phenyl-substituted imidazotriazinones.
GB0113344D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
DE10135815A1 (en) 2001-07-23 2003-02-06 Bayer Ag Use of imidazo-triazinone derivative phosphodiesterase 5 inhibitors e.g. for treatment of cardiac insufficiency, psoriasis, diabetes, cancer, glaucoma, bladder disease, Parkinson's disease or pain
DE10232113A1 (en) * 2002-07-16 2004-01-29 Bayer Ag Medicinal products containing vardenafil hydrochloride trihydrate
DE602004021363D1 (en) * 2003-04-01 2009-07-16 Smithkline Beecham Corp IMIDAZOTRIAZIN COMPOUNDS FOR THE TREATMENT OF CANCER DISEASES
EP2168968B1 (en) 2004-04-02 2017-08-23 OSI Pharmaceuticals, LLC 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
DE102005001989A1 (en) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenous formulations of PDE inhibitors
DE102005009240A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with improved pharmacokinetic properties
DE102005009241A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with controlled bioavailability
CA2623657A1 (en) * 2005-09-29 2007-04-12 Bayer Healthcare Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
KR20080078668A (en) * 2005-11-17 2008-08-27 오에스아이 파마슈티컬스, 인코포레이티드 Fused bicyclic mtor inhibitors
CN101711153A (en) * 2007-06-13 2010-05-19 拜耳先灵制药股份公司 The PDE inhibitor that is used for the treatment of acoustic trauma
CA2752826A1 (en) 2009-04-20 2010-10-28 OSI Pharmaceuticals, LLC Preparation of c-pyrazine-methylamines
CN103374002B (en) * 2012-04-19 2015-07-15 山东轩竹医药科技有限公司 Phosphodiesterase-5 inhibitor
WO2017000276A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017204316A1 (en) * 2016-05-27 2017-11-30 塩野義製薬株式会社 5-oxo-1,2,4-triazine derivative, and pharmaceutical composition thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278673A (en) * 1977-03-25 1981-07-14 Allen & Hanburys Limited Pharmacologically active compounds
EP0009384A1 (en) * 1978-09-18 1980-04-02 Glaxo Group Limited Processes for the preparation of triazinones and condensed triazinones, and compounds so obtained
US5498774A (en) * 1989-06-23 1996-03-12 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO2016147659A1 (en) * 2015-03-16 2016-09-22 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic imidazolo derivative

Also Published As

Publication number Publication date
DE2255172A1 (en) 1973-05-24
IE37046L (en) 1973-05-19
IL40686A0 (en) 1972-12-29
PH9669A (en) 1976-02-10
DK138691C (en) 1979-03-26
DK138691B (en) 1978-10-16
JPS563873B2 (en) 1981-01-27
CA990292A (en) 1976-06-01
SE402915B (en) 1978-07-24
FR2160407B1 (en) 1975-10-17
IE37046B1 (en) 1977-04-27
NL7215646A (en) 1973-05-22
US3840537A (en) 1974-10-08
FR2160407A1 (en) 1973-06-29
ES408736A1 (en) 1976-03-01
AU4819172A (en) 1974-05-16
IL40686A (en) 1975-12-31
ZA727532B (en) 1973-07-25
AU472127B2 (en) 1976-05-20
BE791025A (en) 1973-05-07
JPS4857993A (en) 1973-08-14
CH594671A5 (en) 1978-01-13
AT321923B (en) 1975-04-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee