GB1396219A - Method and reagent for testing blood - Google Patents

Method and reagent for testing blood

Info

Publication number
GB1396219A
GB1396219A GB2370773A GB2370773A GB1396219A GB 1396219 A GB1396219 A GB 1396219A GB 2370773 A GB2370773 A GB 2370773A GB 2370773 A GB2370773 A GB 2370773A GB 1396219 A GB1396219 A GB 1396219A
Authority
GB
United Kingdom
Prior art keywords
sickle cell
reagent
haemolyzing
test
buffer solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2370773A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Publication of GB1396219A publication Critical patent/GB1396219A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1396219 Test for sickle cell disease BAXTER LABORATORIES Inc 18 May 1973 [18 May 1972] 23707/73 Heading G1B A reagent kit for testing blood for sickle cell disease comprises an aqueous phosphate buffer solution of molarity from 2 to 2.5 and pH from 7 to 7.2, and haemolyzing agent and a reducing agent preferably each in powdered form, the buffer solution containing from 0.1 to 1<SP>ml</SP> per litre of a non- ionic surfactant. The haemolyzing agent may be saponin, the reducing agent sodium dithionate and the surfactant octyl or nonyl phenoxy polyethoxyethanol. In carrying out the test, a sample of unclotted blood is mixed with a predetermined proportion of a reagent prepared by mixing the kit components, when a turbidity in the mixture indicates the presence of haemoglobins. A microcapillary sample of the turbid mixture is centrifuged and inspected for results characteristic of sickle cell trait or of sickle cell anaemia.
GB2370773A 1972-05-18 1973-05-18 Method and reagent for testing blood Expired GB1396219A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00254584A US3847545A (en) 1972-05-18 1972-05-18 Diagnostic test for sickle-cell

Publications (1)

Publication Number Publication Date
GB1396219A true GB1396219A (en) 1975-06-04

Family

ID=22964847

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2370773A Expired GB1396219A (en) 1972-05-18 1973-05-18 Method and reagent for testing blood

Country Status (4)

Country Link
US (1) US3847545A (en)
CA (1) CA1009575A (en)
GB (1) GB1396219A (en)
ZA (1) ZA733329B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3918905A (en) * 1973-07-20 1975-11-11 Biolog Corp Of America Diagnostic test for the determination of sickling hemoglobinopathies
DE2803109A1 (en) * 1978-01-25 1979-07-26 Zander Rolf METHOD AND REAGENT FOR DETERMINING THE HAEMOGLOBIN CONTENT OF THE BLOOD
US4236526A (en) * 1978-01-31 1980-12-02 Richard Patricia A Method of screening for sickle cell disease by detection of porphyrins and porphyrin metabolites in human dentition
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5514592A (en) * 1995-02-13 1996-05-07 Medicus Technologies, Inc. Method and composition for testing blood for hemoglobin S that incorporates mineral oil as an insoluble upper phase
US6087398A (en) * 1996-03-01 2000-07-11 South Alabama Medical Science Foundation Sickle cell anemia treatment
US20060096358A1 (en) * 2004-10-28 2006-05-11 University Of Washington Optical projection tomography microscope
US9091677B2 (en) 2010-08-09 2015-07-28 Beckman Coulter, Inc. Isotonic buffered composition and method that enables counting of cells
US8623659B2 (en) 2010-09-24 2014-01-07 Saint Louis University Sickle confirm modified hemoglobin solubility test
WO2014081933A1 (en) 2012-11-21 2014-05-30 Saint Louis University Method of hemoglobin-f determination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492095A (en) * 1967-10-05 1970-01-27 Harold B Tillen Product for and method of testing blood for the presence of hemoglobin s
US3607695A (en) * 1969-02-14 1971-09-21 Pfizer & Co C Hemoglobinopathy controls

Also Published As

Publication number Publication date
US3847545A (en) 1974-11-12
CA1009575A (en) 1977-05-03
ZA733329B (en) 1974-04-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee