GB1396206A - Prostaglandins and the preparation thereof - Google Patents

Prostaglandins and the preparation thereof

Info

Publication number: GB1396206A
Authority: GB; United Kingdom
Prior art keywords: analogues; pge; pgf; prostaglandins; formula
Prior art date: 1972-04-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB1542473A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-04-27

Filing date

1973-03-30

Publication date

1975-06-04

1973-03-30 Application filed by Upjohn Co filed Critical Upjohn Co

1975-06-04 Publication of GB1396206A publication Critical patent/GB1396206A/en

Status Expired legal-status Critical Current

Links

229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 5
150000003180 prostaglandins Chemical class 0.000 title abstract 5
239000002253 acid Substances 0.000 abstract 3
HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical class O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 abstract 2
-1 2-tetrahydropyranyl Chemical group 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000003301 hydrolyzing effect Effects 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
DPOINJQWXDTOSF-DODZYUBVSA-N 13,14-Dihydro PGE1 Chemical class CCCCC[C@H](O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O DPOINJQWXDTOSF-DODZYUBVSA-N 0.000 abstract 1
WMHAOJIJVNDMKA-BRIYLRKRSA-N 13,14-Dihydro PGF-1a Chemical compound CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O WMHAOJIJVNDMKA-BRIYLRKRSA-N 0.000 abstract 1
NVRVNSHHLPQGCU-UHFFFAOYSA-N 6-bromohexanoic acid Chemical compound OC(=O)CCCCCBr NVRVNSHHLPQGCU-UHFFFAOYSA-N 0.000 abstract 1
IASRMNRQZIRYHM-UHFFFAOYSA-N 6-carboxyhexyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCCCCC(=O)O)C1=CC=CC=C1 IASRMNRQZIRYHM-UHFFFAOYSA-N 0.000 abstract 1
JLPQXFFMVVPIRW-UHFFFAOYSA-N 7-bromoheptanoic acid Chemical compound OC(=O)CCCCCCBr JLPQXFFMVVPIRW-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
HWLZQESIRAGTAT-UHFFFAOYSA-N cyclopenta[b]furan-2-one Chemical class C1=CC2=CC(=O)OC2=C1 HWLZQESIRAGTAT-UHFFFAOYSA-N 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000010561 standard procedure Methods 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GB1542473A 1972-04-27 1973-03-30 Prostaglandins and the preparation thereof Expired GB1396206A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24801372A	1972-04-27	1972-04-27

Publications (1)

Publication Number	Publication Date
GB1396206A true GB1396206A (en)	1975-06-04

Family

ID=22937288

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB1542473A Expired GB1396206A (en)	1972-04-27	1973-03-30	Prostaglandins and the preparation thereof
GB3200874A Expired GB1396207A (en)	1972-04-27	1973-03-30	Prostaglandin intermediates and the preparation thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
GB3200874A Expired GB1396207A (en)	1972-04-27	1973-03-30	Prostaglandin intermediates and the preparation thereof

Country Status (8)

Country	Link
JP (2)	JPS5939426B2 (ja)
BE (1)	BE798829A (ja)
CH (1)	CH585198A5 (ja)
FR (1)	FR2183041B1 (ja)
GB (2)	GB1396206A (ja)
HU (1)	HU168570B (ja)
NL (1)	NL7305817A (ja)
ZA (1)	ZA732244B (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2146325A (en) *	1983-09-07	1985-04-17	Erba Farmitalia	16-Fluoro-16,17-didehydro prostanoids and process for their preparation
WO2002094274A1 (en) *	2001-05-18	2002-11-28	Sucampo Ag	Cathartic composition
CN110218776A (zh) *	2019-06-14	2019-09-10	苏州叠代生物科技有限公司	Pcr油相组合物及其制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4052446A (en) *	1973-08-06	1977-10-04	Hoffmann-La Roche Inc.	11,16-substituted prostaglandins
US4017534A (en) *	1974-06-03	1977-04-12	American Cyanamid Company	16-Fluoro-11-deoxy-13-dihydro-prostaglandin
JPS52145350A (en) *	1976-05-31	1977-12-03	Hitachi Ltd	Complete fillet welding of tee joint having vvshaped groove
JPS5524138A (en) *	1978-08-11	1980-02-21	Toray Ind Inc	Optically active synthetic intermediate and its preparation
JPS6072860A (ja) *	1983-09-07	1985-04-24	インデイアナ　ユニバーシテイ　フアウンデーシヨン	１２，１６‐ジフルオロプロスタグランジンｆ↓２‖化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL32552A (en) *	1968-07-29	1975-07-28	Upjohn Co	Prostaglandin analogs
BR6915068D0 (pt) *	1969-03-14	1973-05-24	Upjohn Co	Processo de producao de derivados racemicos de prostaglandina

1973
- 1973-03-30 GB GB1542473A patent/GB1396206A/en not_active Expired
- 1973-03-30 GB GB3200874A patent/GB1396207A/en not_active Expired
- 1973-04-02 ZA ZA732244A patent/ZA732244B/xx unknown
- 1973-04-09 JP JP48039666A patent/JPS5939426B2/ja not_active Expired
- 1973-04-10 CH CH513473A patent/CH585198A5/xx not_active IP Right Cessation
- 1973-04-26 NL NL7305817A patent/NL7305817A/xx not_active Application Discontinuation
- 1973-04-26 FR FR7315207A patent/FR2183041B1/fr not_active Expired
- 1973-04-27 HU HUUO90A patent/HU168570B/hu unknown
- 1973-04-27 BE BE130507A patent/BE798829A/xx not_active IP Right Cessation
1983
- 1983-10-25 JP JP58198427A patent/JPS5938235B2/ja not_active Expired

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2146325A (en) *	1983-09-07	1985-04-17	Erba Farmitalia	16-Fluoro-16,17-didehydro prostanoids and process for their preparation
WO2002094274A1 (en) *	2001-05-18	2002-11-28	Sucampo Ag	Cathartic composition
US6956056B2 (en)	2001-05-18	2005-10-18	Sucampo Ag	Method for providing a cathartic effect
AU2002307725B2 (en) *	2001-05-18	2008-07-10	Sucampo Ag	Cathartic composition
US7459583B2 (en)	2001-05-18	2008-12-02	Sucampo Ag	Method for providing a cathartic effect
CN110218776A (zh) *	2019-06-14	2019-09-10	苏州叠代生物科技有限公司	Pcr油相组合物及其制备方法

Also Published As

Publication number	Publication date
JPS5993070A (ja)	1984-05-29
HU168570B (ja)	1976-05-28
FR2183041A1 (ja)	1973-12-14
ZA732244B (en)	1974-03-27
GB1396207A (en)	1975-06-04
JPS5939426B2 (ja)	1984-09-22
JPS4914458A (ja)	1974-02-07
JPS5938235B2 (ja)	1984-09-14
CH585198A5 (ja)	1977-02-28
BE798829A (fr)	1973-10-29
FR2183041B1 (ja)	1977-11-10
NL7305817A (ja)	1973-10-30

Legal Events

Date	Code	Title	Description
1975-10-15	PS	Patent sealed
1986-11-26	PCNP	Patent ceased through non-payment of renewal fee

Publication	Publication Date	Title
GB1515414A (en)	1978-06-21	2 descarboxy-2-(tetrazol-5-yl)-11-desoxy-15-substituted-omega-pentanorprostaglandins
US4127726A (en)	1978-11-28	Cis-13-PGE2, 15 methyl ethers
US4097508A (en)	1978-06-27	Cis-4,5-didehydro-13,14 dihydro-9, dioxy PGF compounds
IE38241B1 (en)	1978-02-01	Prostanoic acid derivatives
GB1396206A (en)	1975-06-04	Prostaglandins and the preparation thereof
GB1506824A (en)	1978-04-12	Prostaglandins
GB1386146A (en)	1975-03-05	Cyclopentane derivatives
GB1497218A (en)	1978-01-05	Thiaprostaglandins
GB1506817A (en)	1978-04-12	Prostaglandins
US4065628A (en)	1977-12-27	17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGE, compounds
US4001286A (en)	1977-01-04	Phenyl-substituted prostaglandin-β-type anologs
US4115651A (en)	1978-09-19	CIS-4,5-Didehydro-13,14-didehydro-11-deoxy-17-phenyl-18,19,20-trinor-PGF.sub.1α compounds
GB1434620A (en)	1976-05-05	Prostaglandins and the preparation thereof
GB1508168A (en)	1978-04-19	11-deoxy-15-substituted-16,17,18,19,20-pentanorprostaglandins
US4206311A (en)	1980-06-03	2-Decarboxy-2-hydroxy-methyl-13,14-didehydro-17-phenyl PGF compounds
GB1398346A (en)	1975-06-18	Prostaglandins and the preparation thereof
GB1398291A (en)	1975-06-18	Prostaglandin analogues and production thereof
GB1456511A (en)	1976-11-24	P-biphenylyl esters of 15-substituted-16,17,18,19,20-pentanor prostaglandins
GB1462716A (en)	1977-01-26	Prosta-5-cis,11,13-trnas-trienoic acids and derivatives thereof
IE43821L (en)	1976-07-24	Prostaglandins
GB1436831A (en)	1976-05-26	Prostaglandins and the preparation thereof
GB1460519A (en)	1977-01-06	Polyunsaturated prostaglandin derivatives and process
US4005115A (en)	1977-01-25	Phenyl-substituted prostaglandin-A type analogs
GB1445628A (en)	1976-08-11	Prostaglandin derivatives
US4207422A (en)	1980-06-10	2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-13,14-didehydro-PGA, PGD, and PGE compounds