GB1394845A - Process for the preparation of penicillamine - Google Patents
Process for the preparation of penicillamineInfo
- Publication number
- GB1394845A GB1394845A GB5037572A GB5037572A GB1394845A GB 1394845 A GB1394845 A GB 1394845A GB 5037572 A GB5037572 A GB 5037572A GB 5037572 A GB5037572 A GB 5037572A GB 1394845 A GB1394845 A GB 1394845A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiazolidine
- penicillamine
- salt
- carbonamide
- thiazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1394845 Process for penicillamine DEUTSCHE GOLD-UND SILBER-SCHEIDEANSTALT 1 Nov 1972 [15 Nov 1971] 50375/72 Addition to 1346198 Heading C2C The invention comprises a process for the preparation of penicillamine or a homologue thereof which comprises reacting an aliphatic aldehyde branched on the α-carbon atom with sulphur and ammonia to form a #<SP>3</SP>-thiazoline, converting the #<SP>3</SP>-thiazoline with anhydrous hydrogen cyanide into a thiazolidine-4-carbonitrile, hydrolysing the thiazolidine-4-carbonitrile into a salt of a thiazolidine-4-carbonamide by introducing it into aqueous hydrochloric acid containing at least 30% by weight of hydrogen chloride and heating to a temperature of from 40 to 70 C., converting the salt of a thiazolidine-4- carbonamide at a temperature above 80 C. into a salt of a thiazolidine-4-carboxylic acid and an ammonium salt, working up the mixture and separating off the ammonium salt followed by hydrolytic degradation of the thiazolidine-4- carboxylic acid to produce the penicillamine or its homologue.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2156601A DE2156601C3 (en) | 1971-11-15 | 1971-11-15 | Process for the production of DX-PeniciUamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1394845A true GB1394845A (en) | 1975-05-21 |
Family
ID=5825136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5037572A Expired GB1394845A (en) | 1971-11-15 | 1972-11-01 | Process for the preparation of penicillamine |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS566992B2 (en) |
| AU (1) | AU472713B2 (en) |
| BE (1) | BE791411R (en) |
| CH (1) | CH587240A5 (en) |
| CS (1) | CS191252B4 (en) |
| DD (1) | DD101391A6 (en) |
| DE (1) | DE2156601C3 (en) |
| DK (1) | DK145624C (en) |
| EG (1) | EG10782A (en) |
| ES (1) | ES407956A2 (en) |
| FI (1) | FI59398C (en) |
| FR (1) | FR2160483B2 (en) |
| GB (1) | GB1394845A (en) |
| IE (1) | IE36829B1 (en) |
| IL (1) | IL40829A (en) |
| IT (1) | IT1045669B (en) |
| NL (1) | NL175913C (en) |
| NO (1) | NO136193C (en) |
| SE (1) | SE405354B (en) |
| YU (1) | YU39600B (en) |
| ZA (1) | ZA727545B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU715018A3 (en) * | 1976-10-09 | 1980-02-05 | Дегусса (Фирма) | Method of preparing dl-cysteine |
| DE2716476C2 (en) * | 1977-04-14 | 1985-07-11 | Robert Bosch Gmbh, 7000 Stuttgart | Level control device for motor vehicles |
| JPS57195391U (en) * | 1981-06-05 | 1982-12-10 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH540234A (en) * | 1968-09-06 | 1973-08-15 | Degussa | Process for the manufacture of penicillamine |
| JPS584587B2 (en) * | 1977-06-14 | 1983-01-27 | 松下電器産業株式会社 | Rotary viscous agent application method and device |
-
0
- BE BE791411D patent/BE791411R/en active
-
1971
- 1971-11-15 DE DE2156601A patent/DE2156601C3/en not_active Expired
- 1971-12-30 SE SE7116964A patent/SE405354B/en unknown
-
1972
- 1972-10-10 NL NLAANVRAGE7213689,A patent/NL175913C/en active Search and Examination
- 1972-10-17 FI FI2867/72A patent/FI59398C/en active
- 1972-10-18 YU YU2599/72A patent/YU39600B/en unknown
- 1972-10-24 ZA ZA727545A patent/ZA727545B/en unknown
- 1972-10-25 NO NO3846/72A patent/NO136193C/en unknown
- 1972-10-25 ES ES407956A patent/ES407956A2/en not_active Expired
- 1972-11-01 GB GB5037572A patent/GB1394845A/en not_active Expired
- 1972-11-10 IE IE1537/72A patent/IE36829B1/en unknown
- 1972-11-10 DK DK559972A patent/DK145624C/en not_active IP Right Cessation
- 1972-11-11 EG EG458/72A patent/EG10782A/en active
- 1972-11-13 CH CH1648372A patent/CH587240A5/xx not_active IP Right Cessation
- 1972-11-13 AU AU48812/72A patent/AU472713B2/en not_active Expired
- 1972-11-13 DD DD166822A patent/DD101391A6/xx unknown
- 1972-11-13 IT IT53994/72A patent/IT1045669B/en active
- 1972-11-14 IL IL40829A patent/IL40829A/en unknown
- 1972-11-14 JP JP11419972A patent/JPS566992B2/ja not_active Expired
- 1972-11-14 CS CS727709A patent/CS191252B4/en unknown
- 1972-11-15 FR FR7240521A patent/FR2160483B2/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU472713B2 (en) | 1976-06-03 |
| DD101391A6 (en) | 1973-11-12 |
| IL40829A0 (en) | 1973-01-30 |
| IL40829A (en) | 1975-06-25 |
| SE405354B (en) | 1978-12-04 |
| DE2156601C3 (en) | 1979-06-07 |
| CS191252B4 (en) | 1979-06-29 |
| DK145624B (en) | 1983-01-03 |
| ES407956A2 (en) | 1975-11-01 |
| NO136193B (en) | 1977-04-25 |
| DE2156601A1 (en) | 1973-05-24 |
| AU4881272A (en) | 1974-05-16 |
| DK145624C (en) | 1983-07-11 |
| JPS566992B2 (en) | 1981-02-14 |
| NL175913C (en) | 1985-01-16 |
| ZA727545B (en) | 1973-07-25 |
| CH587240A5 (en) | 1977-04-29 |
| IE36829L (en) | 1973-05-15 |
| FI59398B (en) | 1981-04-30 |
| YU259972A (en) | 1982-06-30 |
| BE791411R (en) | 1973-03-01 |
| FR2160483B2 (en) | 1974-08-19 |
| IT1045669B (en) | 1980-06-10 |
| JPS4861421A (en) | 1973-08-28 |
| YU39600B (en) | 1985-03-20 |
| NO136193C (en) | 1977-08-03 |
| IE36829B1 (en) | 1977-03-02 |
| NL7213689A (en) | 1973-05-17 |
| FR2160483A2 (en) | 1973-06-29 |
| EG10782A (en) | 1976-12-31 |
| DE2156601B2 (en) | 1978-10-19 |
| FI59398C (en) | 1981-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |