GB1392584A - Anilides and the production thereof - Google Patents

Anilides and the production thereof

Info

Publication number
GB1392584A
GB1392584A GB2822773A GB2822773A GB1392584A GB 1392584 A GB1392584 A GB 1392584A GB 2822773 A GB2822773 A GB 2822773A GB 2822773 A GB2822773 A GB 2822773A GB 1392584 A GB1392584 A GB 1392584A
Authority
GB
United Kingdom
Prior art keywords
radical
prepared
lower alkyl
compounds
hydroxymethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2822773A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10081371A external-priority patent/JPS4864040A/ja
Priority claimed from JP46104440A external-priority patent/JPS5110232B2/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of GB1392584A publication Critical patent/GB1392584A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1392584 Anilides SUMITOMO CHEMICAL CO Ltd 13 June 1973 28227/73 Heading C2C Novel compounds of Formula I wherein R<SP>1</SP> and R<SP>2</SP> each represent a hydrogen, halogen atom or a lower alkyl, lower alkoxy or trifluoromethyl radical, A represents a carbonyl or a hydroxymethylene radical, R<SP>3</SP> represents a lower alkyl radical, B represents a lower alkylene radical and B represents a (lower alkyl)- amino, a di(lower alkyl)-amino or a basic saturated 5 to 7 membered N-heterocyclic radical of less than twelve carbon atoms, and salts thereof are prepared (i) where A is hydroxymethylene by reduction of the corresponding ketone where A is CO; (ii) compounds where A is CO are prepared by reaction of ZH with the corresponding compound halogen for Z optionally with salt formation. The intermediate halo compounds are prepared by reaction of the free amine with ClCOBHalogen. The intermediate amines are prepared by oxidation of an indole followed by hydrolysis. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having local anaesthetic, anti-arrhythmic and analgesic activity comprise an above novel compound and a carrier or diluent.
GB2822773A 1971-12-13 1973-06-13 Anilides and the production thereof Expired GB1392584A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10081371A JPS4864040A (en) 1971-12-13 1971-12-13
JP46104440A JPS5110232B2 (en) 1971-12-21 1971-12-21

Publications (1)

Publication Number Publication Date
GB1392584A true GB1392584A (en) 1975-04-30

Family

ID=26441771

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2822773A Expired GB1392584A (en) 1971-12-13 1973-06-13 Anilides and the production thereof

Country Status (9)

Country Link
AT (1) AT334343B (en)
BE (1) BE800830A (en)
CA (1) CA1002951A (en)
CH (1) CH582669A5 (en)
DE (1) DE2330124A1 (en)
FR (1) FR2244482B1 (en)
GB (1) GB1392584A (en)
NL (1) NL7308131A (en)
SE (1) SE410732B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456471A (en) * 1980-07-28 1984-06-26 Chevron Research Company Herbicidal N-haloacetyl-2-methyl-6-substituted methoxymethylanilines
US4690950A (en) * 1984-08-20 1987-09-01 Laboratoire L. Lafon 1-[N-(α-amino-α-methylacetyl)aminophenyl]-2-aminopropanone derivatives

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403330A1 (en) * 1977-06-16 1979-04-13 Fabre Sa Pierre NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2449677B1 (en) * 1979-02-26 1986-03-28 Fabre Sa Pierre NOVEL SUBSTITUTED BENZOYL-2 GLYCYLANILIDES DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ANXIOLYTIC DRUGS
US4244730A (en) * 1979-07-02 1981-01-13 Chevron Research Company Herbicidal N-haloacetyl-2-alkyl-6-acylanilines
FR2528424A1 (en) * 1982-06-11 1983-12-16 Fabre Sa Pierre Alpha-hydroxy-benzyl-glycyl-anilide(s) - for treatment of anxiety, prepd. boro:hydride redn. of benzoyl-glycyl-anilide
CH650768A5 (en) * 1982-08-27 1985-08-15 Pharmaton Sa BASIC ACETANILIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE ACETANILIDES.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456471A (en) * 1980-07-28 1984-06-26 Chevron Research Company Herbicidal N-haloacetyl-2-methyl-6-substituted methoxymethylanilines
US4690950A (en) * 1984-08-20 1987-09-01 Laboratoire L. Lafon 1-[N-(α-amino-α-methylacetyl)aminophenyl]-2-aminopropanone derivatives

Also Published As

Publication number Publication date
SE410732B (en) 1979-10-29
FR2244482A1 (en) 1975-04-18
FR2244482B1 (en) 1977-07-01
SE7308261L (en) 1974-12-13
AT334343B (en) 1976-01-10
CH582669A5 (en) 1976-12-15
CA1002951A (en) 1977-01-04
BE800830A (en) 1973-10-01
DE2330124A1 (en) 1975-01-16
NL7308131A (en) 1974-12-16
ATA517073A (en) 1976-05-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee