ES397037A1 - Method of preparation of purine sugar derivatives - Google Patents
Method of preparation of purine sugar derivativesInfo
- Publication number
- ES397037A1 ES397037A1 ES397037A ES397037A ES397037A1 ES 397037 A1 ES397037 A1 ES 397037A1 ES 397037 A ES397037 A ES 397037A ES 397037 A ES397037 A ES 397037A ES 397037 A1 ES397037 A1 ES 397037A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- purine
- see formula
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Method of preparing intermediates for the production of purine sugar derivatives of formula (II): **(See formula)** wherein R1 is a mono-lower alkoxylamino or lower alcoholylthio amino group, and R2 is a hydrogen atom, an amino or lower monoalkoxylamino group with the proviso that one of R1 and R2 is always an amino or alcoholic group, and Z is a blocking group, comprising the steps of: (a) reacting the suitably substituted purine of formula (V): **(See formula)** with an acylating agent; (b) condensing the resulting compound of formula (IV): **(See formula)** where at least one of Y1 and Y2 is a protected group R2CO (A) N-, where A is a hydrogen atom or a lower alcohol group, and R3 is an alcohol group having 1 to 20 atoms of carbon, with a blocked arabinose halide, of formula (VI): **(See formula)** where Z is as defined above; and (c) deacyl the resulting purine sugar, of formula (III): **(See formula)** wherein Y1, Y2 and Z are as defined above, by hydrolysis under basic conditions. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5450370A GB1386584A (en) | 1970-11-16 | 1970-11-16 | Method of preparation of purine sugar derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES397037A1 true ES397037A1 (en) | 1975-03-01 |
Family
ID=10471222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES397037A Expired ES397037A1 (en) | 1970-11-16 | 1971-11-15 | Method of preparation of purine sugar derivatives |
Country Status (9)
| Country | Link |
|---|---|
| AR (1) | AR193229A1 (en) |
| AT (1) | AT339335B (en) |
| CA (1) | CA983484A (en) |
| CH (1) | CH561228A5 (en) |
| CS (1) | CS176178B2 (en) |
| ES (1) | ES397037A1 (en) |
| GB (1) | GB1386584A (en) |
| HU (1) | HU163969B (en) |
| NL (1) | NL7115682A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1562899A (en) * | 1975-06-17 | 1980-03-19 | Wellcome Found | Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof |
| JPH0217199A (en) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | Production of 2'-deoxy-beta-adenosine |
-
1970
- 1970-11-16 GB GB5450370A patent/GB1386584A/en not_active Expired
-
1971
- 1971-11-15 ES ES397037A patent/ES397037A1/en not_active Expired
- 1971-11-15 HU HUWE000452 patent/HU163969B/hu unknown
- 1971-11-15 CS CS797071A patent/CS176178B2/cs unknown
- 1971-11-15 NL NL7115682A patent/NL7115682A/xx not_active Application Discontinuation
- 1971-11-15 CA CA127,718A patent/CA983484A/en not_active Expired
- 1971-11-15 AT AT982371A patent/AT339335B/en not_active IP Right Cessation
- 1971-11-16 CH CH1662871A patent/CH561228A5/xx not_active IP Right Cessation
- 1971-11-16 AR AR23906371A patent/AR193229A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| HU163969B (en) | 1973-11-28 |
| CH561228A5 (en) | 1975-04-30 |
| AT339335B (en) | 1977-10-10 |
| ATA982371A (en) | 1977-02-15 |
| GB1386584A (en) | 1975-03-12 |
| NL7115682A (en) | 1972-05-18 |
| AR193229A1 (en) | 1973-04-11 |
| CA983484A (en) | 1976-02-10 |
| CS176178B2 (en) | 1977-06-30 |
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