GB1384447A - Preparation p-substituted-phenyl salicylic acid ethers and xanthone-2-carboxylic acid compounds therefrom - Google Patents
Preparation p-substituted-phenyl salicylic acid ethers and xanthone-2-carboxylic acid compounds therefromInfo
- Publication number
- GB1384447A GB1384447A GB3253772A GB3253772A GB1384447A GB 1384447 A GB1384447 A GB 1384447A GB 3253772 A GB3253772 A GB 3253772A GB 3253772 A GB3253772 A GB 3253772A GB 1384447 A GB1384447 A GB 1384447A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- xanthone
- phenyl
- salicylic acid
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Abstract
1384447 Salicylic acid ethers and xanthone-2- carboxylic acids SYNTEX CORP 12 July 1972 [12 Jan 1972] 32537/72 Heading C2C A (p-substituted-phenyl) salicylic acid ether, wherein the substituent is carboxy or an ester or amide thereof, is obtained by treating a (psubstituted-phenyl) salicylate with a strong base. Specified bases are alkali metal hydrides, hydroxides, alkoxides, carbonates and amides. The reaction is preferably conducted in polar solvents, and under conditions which discourage cleavage of the salicylate ester bond, e.g. under an inert atmosphere, and substantially anhydrous conditions. Examples are given which illustrate the process. A (p-substituted-phenyl) salicylate may be obtained by condensing p-hydroxybenzoic acid, or an ester or amide thereof with salicylic acid or the acid chloride thereof. Also the (p-substituted-phenyl salicylic acid ether may be cyclized to give the corresponding xanthone-2-carboxylic acid, or ester or amide thereof. The xanthone products are useful for inhibiting the effects of allergic reactions, also as smooth muscle relaxants or vasodilators. They may be administered in association with conventional pharmaceutical excipients.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21728672A | 1972-01-12 | 1972-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1384447A true GB1384447A (en) | 1975-02-19 |
Family
ID=22810414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3253772A Expired GB1384447A (en) | 1972-01-12 | 1972-07-12 | Preparation p-substituted-phenyl salicylic acid ethers and xanthone-2-carboxylic acid compounds therefrom |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS4880534A (en) |
CA (1) | CA967581A (en) |
CH (1) | CH602547A5 (en) |
DE (1) | DE2234152A1 (en) |
ES (2) | ES404789A1 (en) |
FR (1) | FR2167489B1 (en) |
GB (1) | GB1384447A (en) |
NL (1) | NL7209622A (en) |
SE (1) | SE397825B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106977489B (en) * | 2017-04-20 | 2019-05-31 | 清华大学 | A method of preparing polysubstituted xanthones derivative |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642997A (en) * | 1969-06-25 | 1972-02-15 | Merck & Co Inc | Tricyclic carboxylic acids in the treatment of inflammation |
BE759292A (en) * | 1969-11-27 | 1971-05-24 | Allen & Hanburys Ltd | XANTHONE DERIVATIVES, THEIR PREPARATION AND THEIR USE |
-
1972
- 1972-07-12 FR FR7225351A patent/FR2167489B1/fr not_active Expired
- 1972-07-12 DE DE19722234152 patent/DE2234152A1/en active Pending
- 1972-07-12 CH CH1046072A patent/CH602547A5/xx not_active IP Right Cessation
- 1972-07-12 JP JP6984772A patent/JPS4880534A/ja active Pending
- 1972-07-12 ES ES404789A patent/ES404789A1/en not_active Expired
- 1972-07-12 NL NL7209622A patent/NL7209622A/xx not_active Application Discontinuation
- 1972-07-12 SE SE920072A patent/SE397825B/en unknown
- 1972-07-12 CA CA146,890A patent/CA967581A/en not_active Expired
- 1972-07-12 GB GB3253772A patent/GB1384447A/en not_active Expired
-
1975
- 1975-02-20 ES ES75434925A patent/ES434925A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH602547A5 (en) | 1978-07-31 |
ES434925A1 (en) | 1976-12-16 |
FR2167489B1 (en) | 1975-10-31 |
SE397825B (en) | 1977-11-21 |
NL7209622A (en) | 1973-07-16 |
FR2167489A1 (en) | 1973-08-24 |
DE2234152A1 (en) | 1973-07-26 |
JPS4880534A (en) | 1973-10-29 |
CA967581A (en) | 1975-05-13 |
ES404789A1 (en) | 1975-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |