GB1378187A - 11beta-halo-steroids of the oestrane series - Google Patents
11beta-halo-steroids of the oestrane seriesInfo
- Publication number
- GB1378187A GB1378187A GB555572A GB555572A GB1378187A GB 1378187 A GB1378187 A GB 1378187A GB 555572 A GB555572 A GB 555572A GB 555572 A GB555572 A GB 555572A GB 1378187 A GB1378187 A GB 1378187A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- halo
- feb
- alkyl
- 11beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GRXPVLPQNMUNNX-MHJRRCNVSA-N estrane Chemical class C1CC2CCCC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 GRXPVLPQNMUNNX-MHJRRCNVSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- -1 -halo steroids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 210000002149 gonad Anatomy 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1378187 3-Unsubstituted-11#-halo-steroids ORGANON LABORATORIES Ltd 7 Feb 1972 [17 Feb 1971] 5555/72 Heading C2U Novel steroids of the formula wherein R 1 is C 1-4 alkyl; R 2 is O or (α-R<SP>1</SP>)(#-R<SP>11</SP>) in which R<SP>1</SP> is H, alkyl, alkenyl, alkynyl, alkadienyl or alkadiynyl of 1 to 4 carbon atoms and R<SP>11</SP> is free, esterified or etherified OH; R 3 is H or CH 3 ; and R 4 is F, Cl or Br, are prepared by replacement halogenation of 11α-hydroxy steroids, themselves prepared from the corresponding #<SP>4</SP>- 3-ones via their 3-thioketals. 17-Substituents may be interconverted by standard procedures in the 11#-halo steroids or their 11α-ol precursors. The novel steroids are stated to possess anabolic, androgenic, progestative, ovulationinhibiting and gonad-inhibiting activities, and they may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7102079A NL7102079A (en) | 1971-02-17 | 1971-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1378187A true GB1378187A (en) | 1974-12-27 |
Family
ID=19812496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB555572A Expired GB1378187A (en) | 1971-02-17 | 1972-02-07 | 11beta-halo-steroids of the oestrane series |
Country Status (16)
| Country | Link |
|---|---|
| AR (1) | AR197568A1 (en) |
| AT (1) | ATA113072A (en) |
| BE (1) | BE779496A (en) |
| CA (1) | CA968788A (en) |
| DE (1) | DE2207253A1 (en) |
| DK (1) | DK131234B (en) |
| FI (1) | FI49158C (en) |
| FR (1) | FR2125507B1 (en) |
| GB (1) | GB1378187A (en) |
| HU (1) | HU163761B (en) |
| IE (1) | IE36707B1 (en) |
| IL (1) | IL38681A0 (en) |
| NL (1) | NL7102079A (en) |
| PH (1) | PH9439A (en) |
| SE (1) | SE380532B (en) |
| ZA (1) | ZA72618B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640297A (en) * | 1963-11-15 |
-
1971
- 1971-02-17 NL NL7102079A patent/NL7102079A/xx unknown
-
1972
- 1972-01-31 ZA ZA720618A patent/ZA72618B/en unknown
- 1972-02-01 IL IL38681A patent/IL38681A0/en unknown
- 1972-02-07 GB GB555572A patent/GB1378187A/en not_active Expired
- 1972-02-07 IE IE146/72A patent/IE36707B1/en unknown
- 1972-02-08 CA CA134,139A patent/CA968788A/en not_active Expired
- 1972-02-11 FI FI720372A patent/FI49158C/en active
- 1972-02-11 AT AT113072A patent/ATA113072A/en not_active IP Right Cessation
- 1972-02-15 DK DK69072AA patent/DK131234B/en unknown
- 1972-02-15 PH PH13272*UA patent/PH9439A/en unknown
- 1972-02-16 AR AR240534A patent/AR197568A1/en active
- 1972-02-16 SE SE7201822A patent/SE380532B/en unknown
- 1972-02-16 FR FR7205152A patent/FR2125507B1/fr not_active Expired
- 1972-02-16 DE DE19722207253 patent/DE2207253A1/en active Pending
- 1972-02-16 HU HUOA495A patent/HU163761B/hu unknown
- 1972-02-17 BE BE779496A patent/BE779496A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7102079A (en) | 1972-08-21 |
| AR197568A1 (en) | 1974-04-23 |
| FR2125507B1 (en) | 1976-04-16 |
| IE36707L (en) | 1972-08-17 |
| BE779496A (en) | 1972-08-17 |
| IE36707B1 (en) | 1977-02-02 |
| FR2125507A1 (en) | 1972-09-29 |
| ZA72618B (en) | 1972-10-25 |
| DK131234B (en) | 1975-06-16 |
| FI49158C (en) | 1975-04-10 |
| DK131234C (en) | 1975-11-17 |
| PH9439A (en) | 1975-11-26 |
| ATA113072A (en) | 1975-10-15 |
| FI49158B (en) | 1974-12-31 |
| HU163761B (en) | 1973-10-27 |
| IL38681A0 (en) | 1972-04-27 |
| CA968788A (en) | 1975-06-03 |
| DE2207253A1 (en) | 1972-08-31 |
| SE380532B (en) | 1975-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |