GB1340032A - Biologically active ketones - Google Patents

Biologically active ketones

Info

Publication number
GB1340032A
GB1340032A GB5923169A GB1340032DA GB1340032A GB 1340032 A GB1340032 A GB 1340032A GB 5923169 A GB5923169 A GB 5923169A GB 1340032D A GB1340032D A GB 1340032DA GB 1340032 A GB1340032 A GB 1340032A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
dec
reacted
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5923169A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB1340032A publication Critical patent/GB1340032A/en
Priority claimed from CA213,916A external-priority patent/CA977778A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring

Abstract

1340032 m - Halo - α - t - butylaminopropiophenones WELLCOME FOUNDATION Ltd (Burroughs Wellcome & Co (USA) Inc) 3 Dec 1970 [4 Dec 1969] 59231/69 Heading C2C Novel compounds of Formula I and acid addition salts thereof wherein X is Cl or F are prepared by one of the following methods: (a) a compound of Formula Va wherein Hal is Cl, Br or I is reacted with t-butyl amine; (b) a compound of formula is oxidized or (c) a compound of formula wherein R<SP>1</SP> is C 1-3 alkoxy is reacted with t-butylamine and in all eases optionally followed by salt formation. Intermediates of Formula Va above are prepared by halogenation of the ketones of formula obtained by reaction of the appropriate halophenylnitrile with ethyl magnesium bromide followed by acidification. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having antidepressant activity comprise an above novel compound and a carrier or diluent. Treatment of depression in non- human animals comprises administration of the above novel compounds or compositions.
GB5923169A 1969-12-04 1969-12-04 Biologically active ketones Expired GB1340032A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5923169 1969-12-04
CA213,916A CA977778A (en) 1969-12-04 1974-11-15 Intermediates for biologically active ketones

Publications (1)

Publication Number Publication Date
GB1340032A true GB1340032A (en) 1973-12-05

Family

ID=25667756

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5923169A Expired GB1340032A (en) 1969-12-04 1969-12-04 Biologically active ketones

Country Status (1)

Country Link
GB (1) GB1340032A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473884A1 (en) * 1980-01-21 1981-07-24 Wellcome Found ASSOCIATIONS OF A HALOGENO-PROPIOPHENONE AND A DIAZEPINE, TRANQUILIZING MEDICAMENTS CONTAINING SUCH ASSOCIATIONS, AND THEIR PREPARATION
EP0118036A1 (en) * 1983-02-03 1984-09-12 The Wellcome Foundation Limited Biologically active ketone derivative, preparation and use
US7884136B2 (en) 2005-06-27 2011-02-08 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473884A1 (en) * 1980-01-21 1981-07-24 Wellcome Found ASSOCIATIONS OF A HALOGENO-PROPIOPHENONE AND A DIAZEPINE, TRANQUILIZING MEDICAMENTS CONTAINING SUCH ASSOCIATIONS, AND THEIR PREPARATION
US4571395A (en) * 1980-01-21 1986-02-18 Burroughs Wellcome Co. Lorazepam and bupropion, compositions and methods
US4798826A (en) * 1980-01-21 1989-01-17 Burroughs Wellcome Co. Benzodiazepine tranquilizer combinations and the use thereof
EP0118036A1 (en) * 1983-02-03 1984-09-12 The Wellcome Foundation Limited Biologically active ketone derivative, preparation and use
US7884136B2 (en) 2005-06-27 2011-02-08 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
US8932628B2 (en) 2005-06-27 2015-01-13 Valeant International Bermuda Modified release formulations of a bupropion salt
US9504640B2 (en) 2005-06-27 2016-11-29 Valeant Pharmaceuticals Luxembourg S.Á.R.L. Modified release formulations of a bupropion salt

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Legal Events

Date Code Title Description
416 Proceeding under section 16 patents act 1949
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee