GB1325066A - Phthalimidine compounds - Google Patents

Phthalimidine compounds

Info

Publication number
GB1325066A
GB1325066A GB2099772A GB2099770A GB1325066A GB 1325066 A GB1325066 A GB 1325066A GB 2099772 A GB2099772 A GB 2099772A GB 2099770 A GB2099770 A GB 2099770A GB 1325066 A GB1325066 A GB 1325066A
Authority
GB
United Kingdom
Prior art keywords
general formula
mono
hydrogen
alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2099772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of GB1325066A publication Critical patent/GB1325066A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

1325066 N - [2 - (3 - Hydroxy - 2 - phthalimidinyl) - ethyl] - sulphonamides AMERICAN HOME PRODUCTS CORP 2 Oct 1970 [12 Feb 1970] 20997/72 Divided out of 1325065 Heading C2C Novel N - [2 - (3 - Hydroxy - 2 - phthalimidinyl)-ethyl]-sulphonamides of the general formula wherein R<SP>1</SP> is a phenyl, monohalophenyl, dihalophenyl, mono-C 1-5 alkylphenyl, di-C 1-5 alkylphenyl, trifluoromethylphenyl, mono- C 1-6 alkoxyphenyl, di-C 1-6 alkoxyphenyl, thienyl, pyridyl, furyl or 5,6,7,8-tetrahydro- 2-naphthyl group; R<SP>2</SP> is a hydrogen or halogen atom or an amino, C 1-5 alkylamino, C 1-5 alkyl or C 1-6 alkoxy group; R<SP>3</SP> is a hydrogen atom when R<SP>2</SP> and R<SP>3</SP> are dissimilar and when R<SP>2</SP> and R<SP>3</SP> are the same they are both a hydrogen or halogen atom or a C 1-5 alkyl or C 1-6 alkoxy group; R<SP>4</SP> and R<SP>5</SP> are both a hydrogen atom or C 1-5 alkyl group; and R<SP>6</SP> is a C 1-5 alkyl-, phenyl-, mono- or di-halophenyl-, mono- or di-C 1-5 alkylphenyl- or C 1-6 alkoxyphenyl-sulphonyl group, are prepared by reaction of an amine of the first general formula above wherein R<SP>6</SP> is a hydrogen atom with a sulphonyl halide of the general formula R<SP>6</SP>X, wherein X is a halogen atom. When R<SP>4</SP> and R<SP>5</SP> are hydrogen atoms, they may be treated with a strong acid to give 5 - aryl - 2,3 - dihydro - 5H - imidazo[2,1-a]- isoindol-5-ols of the general formula or their tautomeric acid addition salts of the general formula wherein HX is an acid. Amines of the first general formula above wherein R<SP>6</SP> is a hydrogen atom are prepared (a) by hydrolysis of an imidazoisoindolone of the general formula or (b) by reaction of a benzofuranone of the general formula with a diamine of the general formula Imidazoisoindolones of the third general formula above are prepared by reaction of a benzoic acid of the general formula with a diamine of the fifth general formula above.
GB2099772A 1970-02-12 1970-10-02 Phthalimidine compounds Expired GB1325066A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1098470A 1970-02-12 1970-02-12

Publications (1)

Publication Number Publication Date
GB1325066A true GB1325066A (en) 1973-08-01

Family

ID=21748356

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4694070A Expired GB1325065A (en) 1970-02-12 1970-10-02 Imidazoline derivatives
GB2099772A Expired GB1325066A (en) 1970-02-12 1970-10-02 Phthalimidine compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4694070A Expired GB1325065A (en) 1970-02-12 1970-10-02 Imidazoline derivatives

Country Status (15)

Country Link
JP (1) JPS5542997B1 (en)
BE (1) BE762824A (en)
CA (1) CA936533A (en)
CH (2) CH557366A (en)
CY (2) CY786A (en)
DE (1) DE2106694C2 (en)
EG (1) EG10508A (en)
ES (1) ES388196A1 (en)
FR (1) FR2081505B1 (en)
GB (2) GB1325065A (en)
IL (1) IL36017A (en)
MY (2) MY7500062A (en)
NL (1) NL175722C (en)
SE (1) SE410460B (en)
ZA (1) ZA71337B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005278962B2 (en) * 2004-09-02 2012-03-01 Cancer Research Technology Limited Isoindolin-1-one derivatives

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509730A1 (en) * 1981-07-17 1983-01-21 Carpibem NOVEL O-HALOGENES AND O-SUBSTITUTED HETEROCYCLE PHENOLS, PROCESS FOR THE PREPARATION THEREOF, MEDICAMENTS CONTAINING SAME, ESPECIALLY ANTI-HYPERTENISERS, AND NOVEL SYNTHETIC INTERMEDIATES
DE3403730A1 (en) * 1984-02-03 1985-08-08 Hoechst Ag, 6230 Frankfurt ISOINDOLES, METHOD FOR THEIR PRODUCTION AND THEIR USE IN AGRICULTURE
EP0298029B1 (en) * 1987-07-01 1992-12-02 Ciba-Geigy Ag Substituted imidazolones with a herbicidal activity
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888846A (en) * 1967-03-30 1975-06-10 Hoffmann La Roche Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005278962B2 (en) * 2004-09-02 2012-03-01 Cancer Research Technology Limited Isoindolin-1-one derivatives
AU2005278962C1 (en) * 2004-09-02 2012-10-25 Cancer Research Technology Limited Isoindolin-1-one derivatives

Also Published As

Publication number Publication date
NL175722B (en) 1984-07-16
CY787A (en) 1976-06-01
BE762824A (en) 1971-08-11
DE2106694C2 (en) 1984-04-12
MY7500060A (en) 1975-12-31
EG10508A (en) 1976-03-31
GB1325065A (en) 1973-08-01
CH557366A (en) 1974-12-31
JPS5542997B1 (en) 1980-11-04
CH557350A (en) 1974-12-31
IL36017A0 (en) 1971-03-24
ZA71337B (en) 1972-08-30
NL175722C (en) 1984-12-17
CY786A (en) 1976-06-01
IL36017A (en) 1975-03-13
MY7500062A (en) 1975-12-31
CA936533A (en) 1973-11-06
ES388196A1 (en) 1974-03-01
NL7101847A (en) 1971-08-16
DE2106694A1 (en) 1971-08-19
SE410460B (en) 1979-10-15
FR2081505A1 (en) 1971-12-03
FR2081505B1 (en) 1974-08-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee