GB1296505A - - Google Patents

Info

Publication number
GB1296505A
GB1296505A GB1296505DA GB1296505A GB 1296505 A GB1296505 A GB 1296505A GB 1296505D A GB1296505D A GB 1296505DA GB 1296505 A GB1296505 A GB 1296505A
Authority
GB
United Kingdom
Prior art keywords
weight
dopa
june
talc
magnesium stearate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1296505A publication Critical patent/GB1296505A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Abstract

1296505 Pharmaceutical compositions F HOFFMANN-LA ROCHE & CO AG 9 June 1971 [10 June 1970] 19646/71 Heading A5B Pharmaceutical tablets for use in the treatment of Parkinsonism comprising (a) from 60% to 80% by weight L-dopa, (b) from 1% to 10% by weight of a binder comprising amylopectin, polyvinylpyrrolidone or a mixture preferably comprising equal quantities thereof, (c) from 1% to 40% by weight of a tablet disintegrant and (d) from 0.5% to 3% by weight of a tabletting lubricant may be prepared by wet granulating a formulation comprising (a), (b), (c) and (d). The lubricant may comprise talc and stearic acid, calcium stearate, magnesium stearate or products consisting of the di- and tri-glycerides of fatty acids such as stearic and palmitic acid, preferably equal quantities of talc and magnesium stearate; and the disintegrant may comprise microcrystalline cellulose, methyl cellulose, hydroxyethylcellulose or chemically modified starch fractions. The tablets may also contain colouring agents and other therapeutically active ingredients such as compounds which potentiate the action of L-dopa.
GB1296505D 1970-06-10 1971-06-09 Expired GB1296505A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4524470A 1970-06-10 1970-06-10

Publications (1)

Publication Number Publication Date
GB1296505A true GB1296505A (en) 1972-11-15

Family

ID=21936793

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1296505D Expired GB1296505A (en) 1970-06-10 1971-06-09

Country Status (8)

Country Link
US (1) US3632778A (en)
BE (1) BE768269A (en)
DE (1) DE2128461A1 (en)
DK (1) DK126236B (en)
ES (1) ES392066A1 (en)
FR (1) FR2100742B1 (en)
GB (1) GB1296505A (en)
NL (1) NL7107643A (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2246013A1 (en) * 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh PROCESS FOR THE MANUFACTURING OF POROUS TABLETS
US4017636A (en) * 1973-10-23 1977-04-12 Abbott Laboratories Esters of γ-glutamyl amide of dopamine
US4209513A (en) * 1974-02-14 1980-06-24 Burroughs Wellcome Co. Tablet formulation
DE2513940A1 (en) * 1975-03-29 1976-10-14 Merck Patent Gmbh PHARMACEUTICAL PREPARATION
US4097606A (en) * 1975-10-08 1978-06-27 Bristol-Myers Company APAP Tablet containing an alkali metal carboxymethylated starch and processes for manufacturing same
US4143129A (en) * 1975-10-11 1979-03-06 Lilly Industries Limited Cephalexin tablets
DE2551446B2 (en) * 1975-11-15 1977-09-15 Karl Werner Schlüter GmbH, 2000 Ham burg METHOD OF MANUFACTURING SUPPOSITORIES
JPS5332111A (en) * 1976-09-07 1978-03-27 Asahi Chem Ind Co Ltd Composition for tablet
DE2845326C2 (en) * 1978-10-18 1985-05-23 Beiersdorf Ag, 2000 Hamburg Use of a specific microdisperse, amorphous, porous silica for the production of digoxin-containing tablets with a strongly accelerated release of active ingredient
US4195078A (en) * 1979-03-09 1980-03-25 Eli Lilly And Company Nabilone granulation
US4264573A (en) * 1979-05-21 1981-04-28 Rowell Laboratories, Inc. Pharmaceutical formulation for slow release via controlled surface erosion
US4547358A (en) * 1980-05-06 1985-10-15 Mead Johnson & Company Sustained release tablet containing at least 95 percent theophylline
US4465660A (en) * 1981-04-01 1984-08-14 Mead Johnson & Company Sustained release tablet containing at least 95 percent theophylline
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
JPS5839618A (en) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd Long-acting laminated tablet
CH652025A5 (en) * 1981-09-14 1985-10-31 Hoffmann La Roche Pharmaceutical preparation.
US4736527A (en) * 1982-12-13 1988-04-12 Konishiroku Photo Industry Co., Ltd. Apparatus for the heat treatment of powdery material
ATE60711T1 (en) * 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh PHARMACEUTICALS CONTAINING CLODRONATE AND METHOD OF MANUFACTURE THE SAME.
HU209564B (en) * 1991-01-30 1994-07-28 Egyt Gyogyszervegyeszeti Gyar Process for producing rapide tablets containing levodopa and carbidopa
AR100625A1 (en) * 2014-05-29 2016-10-19 Novartis Ag CERITINIB FORMULATION

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133863A (en) * 1961-03-10 1964-05-19 Strong Cobb Arner Inc Sustained release therapeutic tablet compositions comprising organic solvent-gelled gums
US3458622A (en) * 1967-04-07 1969-07-29 Squibb & Sons Inc Controlled release tablet
US3557292A (en) * 1968-08-16 1971-01-19 Hoffmann La Roche Compositions and methods for treating parkinson's disease with combinations of l-3,4-dihydroxyphenylalanine and a hydrazine

Also Published As

Publication number Publication date
DE2128461A1 (en) 1971-12-16
BE768269A (en) 1971-12-09
NL7107643A (en) 1971-12-14
FR2100742A1 (en) 1972-03-24
ES392066A1 (en) 1974-10-16
US3632778A (en) 1972-01-04
FR2100742B1 (en) 1974-09-06
DK126236B (en) 1973-06-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]