GB1293843A - A process for the manufacture of pyridine derivatives - Google Patents
A process for the manufacture of pyridine derivativesInfo
- Publication number
- GB1293843A GB1293843A GB1325970A GB1325970A GB1293843A GB 1293843 A GB1293843 A GB 1293843A GB 1325970 A GB1325970 A GB 1325970A GB 1325970 A GB1325970 A GB 1325970A GB 1293843 A GB1293843 A GB 1293843A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridoxine
- acid
- formula
- oxazolylacetic
- dioxepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1293843 Pyridoxine F HOFFMANN LA ROCHE & CO AG 19 March 1970 [25 March 1969] 13259/70 Heading C2V Pyridoxine and acid addition salts thereof are obtained by heating a mixture of (a) an oxazolylacetic acid of formula where R<SP>1</SP> is hydrogen or a carboxyl group and R<SP>2</SP> is an alkyl group, with (b) a dioxepine compound of formula where R<SP>3</SP> and R<SP>4</SP> are hydrogen, alkyl or phenyl, and (c) a compound of formula where A and B are in trans-configuration and each represents an electron-withdrawing group, and converting the adduct thereby obtained into pyridoxine or an acid addition salt thereof by rearrangement and acidic hydrolysis. In examples : (a) is 5-ethoxy-4-oxazolylacetic acid. and' 2 - carboxy - 5 - ethoxy - 4 - oxazolylacetic acid, (b) is 2 - isopropyl - 4,7 - dihydro - 1,3- dioxepine and (c) is dimethyl fumarate, diethyl fumarate, di-n-butyl fumarate and fumarodinitrile. Other starting materials are mentioned.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH446569A CH505095A (en) | 1969-03-25 | 1969-03-25 | Process for the preparation of pyridoxine |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1293843A true GB1293843A (en) | 1972-10-25 |
Family
ID=4276599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1325970A Expired GB1293843A (en) | 1969-03-25 | 1970-03-19 | A process for the manufacture of pyridine derivatives |
Country Status (9)
Country | Link |
---|---|
BE (1) | BE747826A (en) |
CH (1) | CH505095A (en) |
DE (1) | DE2008854C3 (en) |
DK (1) | DK126195B (en) |
FR (1) | FR2039904A5 (en) |
GB (1) | GB1293843A (en) |
NL (1) | NL7002658A (en) |
SE (1) | SE383516B (en) |
SU (1) | SU416937A3 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4339586A (en) * | 1980-01-11 | 1982-07-13 | Takeda Chemical Industries, Ltd. | Production of pyridoxine |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3013086A1 (en) * | 1980-04-03 | 1981-10-15 | Robert Bosch Gmbh, 7000 Stuttgart | FUEL INJECTION VALVE |
-
1969
- 1969-03-25 CH CH446569A patent/CH505095A/en not_active IP Right Cessation
-
1970
- 1970-02-25 NL NL7002658A patent/NL7002658A/xx not_active Application Discontinuation
- 1970-02-25 DE DE19702008854 patent/DE2008854C3/en not_active Expired
- 1970-03-17 DK DK131470A patent/DK126195B/en unknown
- 1970-03-19 GB GB1325970A patent/GB1293843A/en not_active Expired
- 1970-03-23 SU SU1417314A patent/SU416937A3/en active
- 1970-03-23 BE BE747826D patent/BE747826A/en unknown
- 1970-03-24 FR FR7010501A patent/FR2039904A5/fr not_active Expired
- 1970-03-25 SE SE422070A patent/SE383516B/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4339586A (en) * | 1980-01-11 | 1982-07-13 | Takeda Chemical Industries, Ltd. | Production of pyridoxine |
DK154762B (en) * | 1980-01-11 | 1988-12-19 | Takeda Chemical Industries Ltd | PROCEDURE FOR THE PREPARATION OF PYRIDOXIN OR ACID ADDITION SALTS. |
Also Published As
Publication number | Publication date |
---|---|
FR2039904A5 (en) | 1971-01-15 |
CH505095A (en) | 1971-03-31 |
DE2008854B2 (en) | 1978-02-02 |
DE2008854C3 (en) | 1978-10-05 |
SE383516B (en) | 1976-03-15 |
NL7002658A (en) | 1970-09-29 |
BE747826A (en) | 1970-09-23 |
DK126195B (en) | 1973-06-18 |
SU416937A3 (en) | 1974-02-25 |
DE2008854A1 (en) | 1970-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |