GB1286929A - Process for producing tetracycline by fermentation - Google Patents

Process for producing tetracycline by fermentation

Info

Publication number
GB1286929A
GB1286929A GB30583/71A GB3058371A GB1286929A GB 1286929 A GB1286929 A GB 1286929A GB 30583/71 A GB30583/71 A GB 30583/71A GB 3058371 A GB3058371 A GB 3058371A GB 1286929 A GB1286929 A GB 1286929A
Authority
GB
United Kingdom
Prior art keywords
tetracycline
fermentation
producing
phenaethylicus
loredana
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30583/71A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LORENZINI Sas INST BIOCHIM
Original Assignee
LORENZINI Sas INST BIOCHIM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LORENZINI Sas INST BIOCHIM filed Critical LORENZINI Sas INST BIOCHIM
Publication of GB1286929A publication Critical patent/GB1286929A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1286929 Producing tetracycline ISTITUTO BIOCHIMICO ITALIANO DI LOREDANA LORENZINI SaS 30 June 1971 [17 April 1971] 30583/71 Heading C2A Tetracycline is produced by cultivating Strepto - myces phenaethylicus n. sp. (IMRU. 3948) under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic salts. The micro-organism is a mutant of Streptomyces aureofaciens ATCC. 10762 obtained by treating the latter with phenethyl alcohol together with nitrosoguanidine, dimethyl sulphate or nitrosomethyl-urethane. The fermentation is preferably conducted at an initial pH of 5À8 to 6À7 and a temperature of 26‹ to 32‹ C. Tetracycline is recovered from the filtered broth as the free base or a salt thereof by conventional methods.
GB30583/71A 1971-04-17 1971-06-30 Process for producing tetracycline by fermentation Expired GB1286929A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23347/71A IT1047890B (en) 1971-04-17 1971-04-17 PROCESS FOR THE PRODUCTION OF TETRACYCLINE BY FERMENTATION

Publications (1)

Publication Number Publication Date
GB1286929A true GB1286929A (en) 1972-08-31

Family

ID=11206289

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30583/71A Expired GB1286929A (en) 1971-04-17 1971-06-30 Process for producing tetracycline by fermentation

Country Status (3)

Country Link
CA (1) CA989756A (en)
GB (1) GB1286929A (en)
IT (1) IT1047890B (en)

Also Published As

Publication number Publication date
IT1047890B (en) 1980-10-20
CA989756A (en) 1976-05-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee