GB1286093A - Water-soluble corticoids - Google Patents

Water-soluble corticoids

Info

Publication number
GB1286093A
GB1286093A GB41152/69A GB4115269A GB1286093A GB 1286093 A GB1286093 A GB 1286093A GB 41152/69 A GB41152/69 A GB 41152/69A GB 4115269 A GB4115269 A GB 4115269A GB 1286093 A GB1286093 A GB 1286093A
Authority
GB
United Kingdom
Prior art keywords
give
converted
reacted
acid
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41152/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19681793218 external-priority patent/DE1793218C3/en
Priority claimed from DE1902651A external-priority patent/DE1902651C3/en
Priority claimed from DE19691920634 external-priority patent/DE1920634C3/en
Application filed by Schering AG filed Critical Schering AG
Publication of GB1286093A publication Critical patent/GB1286093A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1286093 #<SP>1</SP>'<SP>4</SP>-16α-methyl steroids SCHERING AG 18 Aug 1969 [17 Aug 1968 15 Jan 1969 19 April 1969] 41152/69 Heading C2U Novel steroids of the formula [where R 1 is H, Cl or F; and Y is SO 3 M, P0 3 M 2 , or CO(CH 2 ) n NR 2 R 3 .HX in which M is an alkali metal, HX is an acid, n is 1, 2 or 3, and R 2 and R 3 are each alkyl or together are alkylene which may be interrupted by a hetero atom) are prepared by esterification of the free 21-ols by standard procedures. Thus the ols may be (a) reacted with pyridine-S0 3 adduct to give the acid sulphuric acid esters and these converted to the required salts with suitable bases; or (b) converted to sulphonates, e.g. mesylates, these converted to 21-iodo compounds and these heated with H 3 P0 4 in presence of an organic base to give the 21-monophosphates which with alkali give the required salts; or (c) reacted with derivatives of halo-alkanoic acids to give 21-halo-alkanoates and these then reacted with amines NHR 3 R 4 and the products converted to acid-addition salts. The novel anti-inflammatory steroids may be made up into pharmaceutical compositions with suitable carriers. Reference has been directed by the Comptroller to Specifications 990,384 and 1,068,058.
GB41152/69A 1968-08-17 1969-08-18 Water-soluble corticoids Expired GB1286093A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19681793218 DE1793218C3 (en) 1968-08-17 1968-08-17 Water-soluble 21-hemisulfate alkali metal compounds of 6 a-fluoro-11 ß, 21-dihydroxy-16 a-methyl-3,20-dioxo-1,4-pregnadienes, processes for their preparation and pharmaceuticals containing them
DE1902651A DE1902651C3 (en) 1969-01-15 1969-01-15 New corticosteroid-21-monophosphates, processes for their preparation and medicinal products containing them
DE19691920634 DE1920634C3 (en) 1969-04-19 1969-04-19 Water-soluble corticosteroid-21-aminoacylates, processes for their preparation and pharmaceuticals containing them

Publications (1)

Publication Number Publication Date
GB1286093A true GB1286093A (en) 1972-08-16

Family

ID=27181456

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41152/69A Expired GB1286093A (en) 1968-08-17 1969-08-18 Water-soluble corticoids

Country Status (11)

Country Link
BE (1) BE737501A (en)
BR (1) BR6911575D0 (en)
CH (1) CH527177A (en)
ES (1) ES370164A1 (en)
FR (1) FR2015858A1 (en)
GB (1) GB1286093A (en)
IL (1) IL32814A (en)
NL (1) NL6912571A (en)
NO (1) NO131427C (en)
SE (1) SE352348B (en)
YU (1) YU34304B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2715853A1 (en) * 1977-04-06 1978-10-19 Schering Ag WATER-SOLUBLE CORTICOIDS
WO2017199862A1 (en) * 2016-05-18 2017-11-23 日本ゼオン株式会社 Polymerizable compound manufacturing method, halogenated substance, and mixture

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2920726A1 (en) * 1979-05-18 1980-11-27 Schering Ag NEW CORTICOIDS, THEIR PRODUCTION AND USE
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
CN110800738A (en) * 2019-11-11 2020-02-18 福州科理技术开发有限公司 Deodorizing and pest killing spray liquid for kitchen garbage and its prepn

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2715853A1 (en) * 1977-04-06 1978-10-19 Schering Ag WATER-SOLUBLE CORTICOIDS
WO2017199862A1 (en) * 2016-05-18 2017-11-23 日本ゼオン株式会社 Polymerizable compound manufacturing method, halogenated substance, and mixture
JP2017206461A (en) * 2016-05-18 2017-11-24 日本ゼオン株式会社 Method for producing polymerizable compound

Also Published As

Publication number Publication date
IL32814A (en) 1973-06-29
SE352348B (en) 1972-12-27
FR2015858A1 (en) 1970-04-30
YU34304B (en) 1979-04-30
YU188969A (en) 1978-10-31
NL6912571A (en) 1970-02-19
CH527177A (en) 1972-08-31
ES370164A1 (en) 1971-04-01
BE737501A (en) 1970-02-16
IL32814A0 (en) 1969-11-12
NO131427B (en) 1975-02-17
BR6911575D0 (en) 1973-02-13
NO131427C (en) 1975-05-28

Similar Documents

Publication Publication Date Title
ES417738A1 (en) Process for preparing 17{60 -monoesters of 17{60 , 21-dihydroxy-20-oxo steroids
GB1286093A (en) Water-soluble corticoids
GB1352027A (en) Process for the manufacture of pregnane compounds and process for the manufacture of sulphite esters
GB1363472A (en) 17-chlorosteroids
GB1074495A (en) Novel gonane derivatives and processes for their preparation
GB1308849A (en) Process for the preparation of 6alpha-methyl-19-nor-pregnenes
GB1395019A (en) Polyesters and their use as plasticizers
GB1317194A (en) 21,21-dichloro-steroids
ES428213A1 (en) Dialkylaminoalkyl esters of penicillin and process for the preparation thereof
GB1355663A (en) 19-nortestosterone 17- -p-substituted phenoxy-acetates
GB1047542A (en) 21-galacturonides of steroids
SE7514455L (en) 13-ETHYNYLSTEROIDS AND WAY TO PRODUCE THESE
GB1137612A (en) Proscillaridin derivatives
ES391117A1 (en) Novel c-16,17 spiro-orthoester steroids and preparation
ES360357A1 (en) Delta 4,9,11-gonatriene-3-ones
GB1272688A (en) Sulphamido-steroids and the preparation thereof
GB1312532A (en) Process for the esterification of 17-hydroxy steroids
ES382050A1 (en) Process for preparing esters of the para-diphenyl acetic acid
ES410021A1 (en) Amidothionophosphoric acid esters
GB1320301A (en) 21-fluorosteroids and their preparation
GB1016375A (en) Steroid esters
GB1149102A (en) A method of preparing new halogenated compounds of the pregnane series
GB1099248A (en) Water-insoluble anthraquinone dyestuffs and a process for their manufacture
GB1505701A (en) 2-chloro-6beta-fluoropregnanes
GB1440251A (en) Production of beta-dicarbonyl compounds

Legal Events

Date Code Title Description
429A Application made for amendment of specification (sect. 29/1949)
429H Application (made) for amendment of specification now open to opposition (sect. 29/1949)
429D Case decided by the comptroller ** specification amended (sect. 29/1949)
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee