GB1273916A - Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents - Google Patents

Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents

Info

Publication number
GB1273916A
GB1273916A GB3680870A GB3680870A GB1273916A GB 1273916 A GB1273916 A GB 1273916A GB 3680870 A GB3680870 A GB 3680870A GB 3680870 A GB3680870 A GB 3680870A GB 1273916 A GB1273916 A GB 1273916A
Authority
GB
United Kingdom
Prior art keywords
compound
novel
analgesic
quinazolinones
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3680870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB1273916A publication Critical patent/GB1273916A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,273,916. 6,7-Dimethoxy quinazolinones. PFIZER Inc. 29 July, 1970 [7-April, 1970], No. 36808/70. Heading C2C. Novel 6,7-dimethoxy quinazolinones of the Formula I wherein Z is CN, COR, COCF 3 , CONRR<SP>1</SP> or COOR except Z is not COOH and R 1 , R 2 , R, R<SP>1</SP> are hydrogen or C 1-4 alkyl may be prepared by reducing a compound II to produce the compound which is condensed with Z-halide alone or Z- OR in the presence of a base to give I. The compound II may be prepared by condensing an NN<SP>1</SP>-disubstituted amide with a 4,5-dimethoxyanthranilic ester in the presence of phosphorous oxychloride, thionyl chloride or phosgene, followed by cyclization of the amidino product with an amine R 1 NH 2 , where R 3 and R 4 are typically lower alkyl to give II. Pharmaceutical compositions of .1 with the usual excipients show analgesic and tranquillizer activity when administered orally or parenterally.
GB3680870A 1970-04-07 1970-07-29 Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents Expired GB1273916A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2640670A 1970-04-07 1970-04-07

Publications (1)

Publication Number Publication Date
GB1273916A true GB1273916A (en) 1972-05-10

Family

ID=21831651

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3680870A Expired GB1273916A (en) 1970-04-07 1970-07-29 Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents

Country Status (10)

Country Link
JP (1) JPS502992B1 (en)
BE (1) BE765343A (en)
CH (1) CH522654A (en)
DE (1) DE2116079C3 (en)
ES (1) ES389924A1 (en)
FR (1) FR2092015B1 (en)
GB (1) GB1273916A (en)
MY (1) MY7400194A (en)
NL (1) NL141872B (en)
SE (1) SE378595B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59175170U (en) * 1983-05-09 1984-11-22 日本碍子株式会社 Oxygen concentration detector with heater

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092631A (en) * 1963-06-04 Y-chloro-z-lower alkyl-i
CH474525A (en) * 1967-06-20 1969-06-30 S Chimiques Et Pharma Seceph S Process for the preparation of novel quinazoline derivatives

Also Published As

Publication number Publication date
NL7104580A (en) 1971-10-11
FR2092015A1 (en) 1972-01-21
DE2116079B2 (en) 1974-06-12
BE765343A (en) 1971-10-06
SE378595B (en) 1975-09-08
CH522654A (en) 1972-06-30
DE2116079C3 (en) 1975-02-20
DE2116079A1 (en) 1972-02-17
FR2092015B1 (en) 1975-01-17
NL141872B (en) 1974-04-16
ES389924A1 (en) 1973-06-01
MY7400194A (en) 1974-12-31
JPS502992B1 (en) 1975-01-30

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee