ES389924A1 - Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents - Google Patents
Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agentsInfo
- Publication number
- ES389924A1 ES389924A1 ES389924A ES389924A ES389924A1 ES 389924 A1 ES389924 A1 ES 389924A1 ES 389924 A ES389924 A ES 389924A ES 389924 A ES389924 A ES 389924A ES 389924 A1 ES389924 A1 ES 389924A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- novel
- analgesic
- dimethoxyquinazolinones
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel 6,7-dimethoxy quinazolinones of the Formula I wherein Z is CN, COR, COCF 3 , CONRR1 or COOR except Z is not COOH and R 1 , R 2 , R, R1 are hydrogen or C 1-4 alkyl may be prepared by reducing a compound II to produce the compound which is condensed with Z-halide alone or Z- OR in the presence of a base to give I. The compound II may be prepared by condensing an NN1-disubstituted amide with a 4,5-dimethoxyanthranilic ester in the presence of phosphorous oxychloride, thionyl chloride or phosgene, followed by cyclization of the amidino product with an amine R 1 NH 2 , where R 3 and R 4 are typically lower alkyl to give II. Pharmaceutical compositions of .1 with the usual excipients show analgesic and tranquillizer activity when administered orally or parenterally.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2640670A | 1970-04-07 | 1970-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES389924A1 true ES389924A1 (en) | 1973-06-01 |
Family
ID=21831651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES389924A Expired ES389924A1 (en) | 1970-04-07 | 1971-04-05 | Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS502992B1 (en) |
BE (1) | BE765343A (en) |
CH (1) | CH522654A (en) |
DE (1) | DE2116079C3 (en) |
ES (1) | ES389924A1 (en) |
FR (1) | FR2092015B1 (en) |
GB (1) | GB1273916A (en) |
MY (1) | MY7400194A (en) |
NL (1) | NL141872B (en) |
SE (1) | SE378595B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59175170U (en) * | 1983-05-09 | 1984-11-22 | 日本碍子株式会社 | Oxygen concentration detector with heater |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3092631A (en) * | 1963-06-04 | Y-chloro-z-lower alkyl-i | ||
CH474524A (en) * | 1967-06-20 | 1969-02-28 | S Chimiques Et Pharma Seceph S | Process for the preparation of quinazoline derivatives |
-
1970
- 1970-07-29 GB GB3680870A patent/GB1273916A/en not_active Expired
-
1971
- 1971-04-02 DE DE19712116079 patent/DE2116079C3/en not_active Expired
- 1971-04-05 CH CH488871A patent/CH522654A/en not_active IP Right Cessation
- 1971-04-05 ES ES389924A patent/ES389924A1/en not_active Expired
- 1971-04-06 BE BE765343A patent/BE765343A/en unknown
- 1971-04-06 NL NL7104580A patent/NL141872B/en not_active IP Right Cessation
- 1971-04-07 SE SE460571A patent/SE378595B/xx unknown
- 1971-04-07 FR FR7112339A patent/FR2092015B1/fr not_active Expired
- 1971-04-07 JP JP2111871A patent/JPS502992B1/ja active Pending
-
1974
- 1974-12-30 MY MY7400194A patent/MY7400194A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE2116079B2 (en) | 1974-06-12 |
DE2116079A1 (en) | 1972-02-17 |
CH522654A (en) | 1972-06-30 |
MY7400194A (en) | 1974-12-31 |
SE378595B (en) | 1975-09-08 |
FR2092015A1 (en) | 1972-01-21 |
NL7104580A (en) | 1971-10-11 |
FR2092015B1 (en) | 1975-01-17 |
JPS502992B1 (en) | 1975-01-30 |
GB1273916A (en) | 1972-05-10 |
BE765343A (en) | 1971-10-06 |
DE2116079C3 (en) | 1975-02-20 |
NL141872B (en) | 1974-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES336256A1 (en) | Azaspirodecanediones and azaspiroundecanediones | |
GB1309835A (en) | Trialkoxy-quinazolines | |
GB1467927A (en) | Derivatives of tyrosine having a pharmaceutical activity on smooth muscles | |
GB1455687A (en) | Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines | |
GB1459065A (en) | Therapeutic thiophene derivatives | |
GB1506914A (en) | 2-dihalophenylamino-2-imidazoline derivatives | |
ES359454A1 (en) | 2-anilino-nicotinic acid esters | |
GB1471910A (en) | Lysine salt | |
ES389924A1 (en) | Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents | |
GB1277789A (en) | Improvements in or relating to new polycyclic pyrrole derivatives | |
GB1250792A (en) | ||
GB1057667A (en) | Substituted anthranilamides and process for the preparation thereof | |
GB1511266A (en) | Pyridopyrazines | |
GB1299201A (en) | Medicaments derived from thiazolidine carboxylic acid | |
ES350752A1 (en) | 2-methyl or phenyl-7- or 8-chloroquinolines | |
GB1511599A (en) | N-(4-benzamido)-2-pyrrolidone-4-carboxylic acids and derivatives thereof | |
GB1240224A (en) | Improvements in or relating to hydroxylamine derivatives | |
GB1349138A (en) | Quinazoline derivative | |
GB1331407A (en) | 2-iso-propyl tetrahydro-1,3-substituted oxazines their process of preparation and their therapeutic application | |
GB1297035A (en) | ||
ES374762A1 (en) | Benzo(b)benzofurano(2 3-e)oxepines | |
GB1499420A (en) | Ergot peptide alkaloids | |
GB1165603A (en) | Alkanoic Acids and their Derivatives | |
GB1416705A (en) | Keto-esters | |
GB1470493A (en) | Anti-hypertensive 4-1-2-naphthyl-methyl-1,2,5,6-tetrahydro pyrid-4-yl-chroman-5-ol esters |