ES389924A1 - Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents - Google Patents
Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agentsInfo
- Publication number
- ES389924A1 ES389924A1 ES389924A ES389924A ES389924A1 ES 389924 A1 ES389924 A1 ES 389924A1 ES 389924 A ES389924 A ES 389924A ES 389924 A ES389924 A ES 389924A ES 389924 A1 ES389924 A1 ES 389924A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- novel
- analgesic
- dimethoxyquinazolinones
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel 6,7-dimethoxy quinazolinones of the Formula I wherein Z is CN, COR, COCF 3 , CONRR1 or COOR except Z is not COOH and R 1 , R 2 , R, R1 are hydrogen or C 1-4 alkyl may be prepared by reducing a compound II to produce the compound which is condensed with Z-halide alone or Z- OR in the presence of a base to give I. The compound II may be prepared by condensing an NN1-disubstituted amide with a 4,5-dimethoxyanthranilic ester in the presence of phosphorous oxychloride, thionyl chloride or phosgene, followed by cyclization of the amidino product with an amine R 1 NH 2 , where R 3 and R 4 are typically lower alkyl to give II. Pharmaceutical compositions of .1 with the usual excipients show analgesic and tranquillizer activity when administered orally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2640670A | 1970-04-07 | 1970-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES389924A1 true ES389924A1 (en) | 1973-06-01 |
Family
ID=21831651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES389924A Expired ES389924A1 (en) | 1970-04-07 | 1971-04-05 | Novel 6,7-dimethoxyquinazolinones useful as analgesic and tranquilizer agents |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS502992B1 (en) |
| BE (1) | BE765343A (en) |
| CH (1) | CH522654A (en) |
| DE (1) | DE2116079C3 (en) |
| ES (1) | ES389924A1 (en) |
| FR (1) | FR2092015B1 (en) |
| GB (1) | GB1273916A (en) |
| MY (1) | MY7400194A (en) |
| NL (1) | NL141872B (en) |
| SE (1) | SE378595B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59175170U (en) * | 1983-05-09 | 1984-11-22 | 日本碍子株式会社 | Oxygen concentration detector with heater |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092631A (en) * | 1963-06-04 | Y-chloro-z-lower alkyl-i | ||
| CH474524A (en) * | 1967-06-20 | 1969-02-28 | S Chimiques Et Pharma Seceph S | Process for the preparation of quinazoline derivatives |
-
1970
- 1970-07-29 GB GB3680870A patent/GB1273916A/en not_active Expired
-
1971
- 1971-04-02 DE DE19712116079 patent/DE2116079C3/en not_active Expired
- 1971-04-05 CH CH488871A patent/CH522654A/en not_active IP Right Cessation
- 1971-04-05 ES ES389924A patent/ES389924A1/en not_active Expired
- 1971-04-06 BE BE765343A patent/BE765343A/en unknown
- 1971-04-06 NL NL7104580A patent/NL141872B/en not_active IP Right Cessation
- 1971-04-07 SE SE460571A patent/SE378595B/xx unknown
- 1971-04-07 FR FR7112339A patent/FR2092015B1/fr not_active Expired
- 1971-04-07 JP JP2111871A patent/JPS502992B1/ja active Pending
-
1974
- 1974-12-30 MY MY7400194A patent/MY7400194A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2116079B2 (en) | 1974-06-12 |
| DE2116079A1 (en) | 1972-02-17 |
| CH522654A (en) | 1972-06-30 |
| MY7400194A (en) | 1974-12-31 |
| SE378595B (en) | 1975-09-08 |
| FR2092015A1 (en) | 1972-01-21 |
| NL7104580A (en) | 1971-10-11 |
| FR2092015B1 (en) | 1975-01-17 |
| JPS502992B1 (en) | 1975-01-30 |
| GB1273916A (en) | 1972-05-10 |
| BE765343A (en) | 1971-10-06 |
| DE2116079C3 (en) | 1975-02-20 |
| NL141872B (en) | 1974-04-16 |
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