GB1259789A - Washing process and centrifuge assembly - Google Patents

Washing process and centrifuge assembly

Info

Publication number
GB1259789A
GB1259789A GB11595/69A GB1159569A GB1259789A GB 1259789 A GB1259789 A GB 1259789A GB 11595/69 A GB11595/69 A GB 11595/69A GB 1159569 A GB1159569 A GB 1159569A GB 1259789 A GB1259789 A GB 1259789A
Authority
GB
United Kingdom
Prior art keywords
influent
containers
effluent
conduits
rotor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11595/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US713595A priority Critical patent/US3561672A/en
Priority to BE728823D priority patent/BE728823A/xx
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Priority to GB9661/71A priority patent/GB1259790A/en
Priority to GB11595/69A priority patent/GB1259789A/en
Priority to DE19691912920 priority patent/DE1912920A1/en
Priority to FR6907563A priority patent/FR2004135A1/fr
Priority to NL6904083A priority patent/NL6904083A/xx
Priority to SE03769/69A priority patent/SE357308B/xx
Priority to US00097407A priority patent/US3719406A/en
Publication of GB1259789A publication Critical patent/GB1259789A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B1/00—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B1/00—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles
    • B04B1/10—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles with discharging outlets in the plane of the maximum diameter of the bowl
    • B04B1/14—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles with discharging outlets in the plane of the maximum diameter of the bowl with periodical discharge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/06—Arrangement of distributors or collectors in centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/12—Suspending rotary bowls ; Bearings; Packings for bearings

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)

Abstract

1,259,789. Centrifugal separator. BAXTER LABORATORIES Inc. 5 March, 1969 [18 March, 1968], No. 11595/69. Heading B2P. A centrifuge for washing preserved red blood cells, Figs. 1 and 2, comprises a rotor 21, a pair of containers 37, 38 supported from the rotor, charging means including a pump for effecting influent washing fluid flow of predetermined volume into each of the containers under an independent pressure head as the rotor spins for washing the cells 36 contained therein, means defining an independent influent path for each of said containers, and discharging means for collecting effluent spent washing fluid from each of the containers. The rotor 21 has a hub 25 with outwardly projecting radial members 26 from which in turn project pairs of arms 29 on which receptacles 23, 24 are pivotably mounted. The containers 37, 38 are supported on conical seats 39 in the receptacles, each of which is closed by a slidable cap 41 through which extend influent and effluent ducts 43, 45. The latter are connected via a fluid control centrifugal clamp assembly 51, a disposable distributor-collector 89, flexible conduits 145, 147 and 149, 151, tubes 235, 237 and control box 245 respectively to a pump 153 or to an influent reservoir 233 and an effluent tank 155. The clamp assembly 51, Fig. 10, is secured to the hub 25 and comprises a clamping mechanism 58 which is associated with each of the containers 37, 38 and consists of a spring biased block 59 slidable in a well 56 (57) in a body 55 and carrying a T-shape clamp member 67 having recesses 77, 78 through which the influent and effluent ducts 43, 45 of the associated container 37 (38) extend. When the centrifuge is stationary, the receptacles 23, 24 are in the position shown in Fig. 1, and the clamp members 67 are in the position shown on the right of Fig. 10 thereby blocking the ducts 43, 45 to prevent flow into and out of the containers 37, 38. When the centrifuge is rotating the receptacles 23, 24 are in the position shown in Fig. 2 and the clamp member 67 are in the position shown on the left of Fig. 10 thereby opening the ducts 43, 45 to permit flow into and out of the containers. The distributor-collector 89; Fig. 4, comprises a cup-shaped rotor 97 and a cylindrical stator 105 between which are provided influent and effluent chambers 123, 125 and 127, 129 respectively. The chamber 123 is associated with container 38 and, through a bore 137 in the stator, with the influent conduit 145. The chamber 125 is associated with the container 37 and, through a bore in the stator with influent conduit 147. The chamber 127 is in communication with the container 37 and the effluent conduit 49 and the chamber 129 with container 38 and effluent conduit 151. An upper end portion 165 of the stator head 111 is supported for movement in mutually perpendicular directions on a removable bearing mechanism 157 (see Specification 1,259,790) to accommodate for stresses imparted to the stator by the rotating rotor. The rotor has a spigot portion 95 which engages in an opening 91 in the body 55 of the clamp assembly 51. The pump 153 is of the roller type and delivers equal volumes of influent to the containers 37, 38 via the conduits 145, 147. The reservoir 153 is connected to the pump and, alternatively, for initial filling of the centrifuge with influent, directly to the conduits 145, 147 through the tubes 235, 237. The tank 155 receives the effluent via the conduits 149, 151. Portions of the conduits 145, 147, 149, 151 and of the tubes 235, 237 are disposed in grooves in a top plate of the control box 245 in which are arranged solenoids and their associated electrical circuitry. Pressure pads 267, 269, 271 are carried on the ends of reciprocable arms controlled by the solenoids. The parts are arranged so that when a solenoid is de-energized, the flow paths through its associated tubes, ducts and conduits are open. When a solenoid is energized its pressure pad will be projected to clamp its associated ducts, conduits and tubes to cut their flow paths.
GB11595/69A 1968-03-18 1969-03-05 Washing process and centrifuge assembly Expired GB1259789A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US713595A US3561672A (en) 1968-03-18 1968-03-18 Washing process and centrifuge assembly
BE728823D BE728823A (en) 1968-03-18 1969-02-24
GB9661/71A GB1259790A (en) 1968-03-18 1969-03-05 Bearing mechanism for stator and rotor
GB11595/69A GB1259789A (en) 1968-03-18 1969-03-05 Washing process and centrifuge assembly
DE19691912920 DE1912920A1 (en) 1968-03-18 1969-03-14 Washer centrifuge device and centrifugation method
FR6907563A FR2004135A1 (en) 1968-03-18 1969-03-17
NL6904083A NL6904083A (en) 1968-03-18 1969-03-17
SE03769/69A SE357308B (en) 1968-03-18 1969-03-18
US00097407A US3719406A (en) 1968-03-18 1970-11-16 Bearing mechanism for centrifuge assembly

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71359568A 1968-03-18 1968-03-18
GB11595/69A GB1259789A (en) 1968-03-18 1969-03-05 Washing process and centrifuge assembly
US9740770A 1970-11-16 1970-11-16

Publications (1)

Publication Number Publication Date
GB1259789A true GB1259789A (en) 1972-01-12

Family

ID=27256704

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9661/71A Expired GB1259790A (en) 1968-03-18 1969-03-05 Bearing mechanism for stator and rotor
GB11595/69A Expired GB1259789A (en) 1968-03-18 1969-03-05 Washing process and centrifuge assembly

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB9661/71A Expired GB1259790A (en) 1968-03-18 1969-03-05 Bearing mechanism for stator and rotor

Country Status (7)

Country Link
US (2) US3561672A (en)
BE (1) BE728823A (en)
DE (1) DE1912920A1 (en)
FR (1) FR2004135A1 (en)
GB (2) GB1259790A (en)
NL (1) NL6904083A (en)
SE (1) SE357308B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3347454A (en) * 1964-05-13 1967-10-17 Baxter Laboratories Inc Method and apparatus for the centrifugal washing of particles in a closed system
US3877634A (en) * 1973-05-25 1975-04-15 Du Pont Cell washing centrifuge apparatus and system
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US4056224A (en) * 1975-03-27 1977-11-01 Baxter Travenol Laboratories, Inc. Flow system for centrifugal liquid processing apparatus
US4091989A (en) * 1977-01-04 1978-05-30 Schlutz Charles A Continuous flow fractionation and separation device and method
US4098456A (en) * 1977-03-29 1978-07-04 Baxter Travenol Laboratories, Inc. Centrifuge system having collapsible centrifuge bags
US4098455A (en) * 1977-03-29 1978-07-04 Baxter Travenol Laboratories, Inc. Rotary seal distributor member for a centrifuge
US4413772A (en) * 1979-09-10 1983-11-08 E. I. Du Pont De Nemours And Company Apparatus for centrifugal separation
US4413773A (en) * 1979-09-10 1983-11-08 E. I. Du Pont De Nemours And Company Method and apparatus for centrifugal separation
US4439177A (en) * 1981-10-26 1984-03-27 Beckman Instruments, Inc. Rotor bucket liner
US5656163A (en) 1987-01-30 1997-08-12 Baxter International Inc. Chamber for use in a rotating field to separate blood components
US5792372A (en) * 1987-01-30 1998-08-11 Baxter International, Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
WO1993012888A1 (en) * 1991-12-23 1993-07-08 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US6007725A (en) * 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5690835A (en) * 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
JPH06505675A (en) * 1991-12-23 1994-06-30 バクスター、インターナショナル、インコーポレイテッド Centrifugal processing system with direct access drawer
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5328440A (en) * 1992-01-07 1994-07-12 Marathon Oil Company Centrifuge bucket and method of use
DE4324893C2 (en) * 1993-07-24 1997-08-28 Hettich Andreas Fa Continuous tube centrifuge
US5427695A (en) * 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
DE19538529A1 (en) * 1995-10-06 1997-04-10 Inst Bioprozess Analysenmesst Laboratory rotating separator assembly
ATE253984T1 (en) 1997-02-14 2003-11-15 Dendreon Corp METHOD AND APPARATUS FOR WASHING CELLS
US7001322B2 (en) * 2000-10-04 2006-02-21 Zymequest, Inc. Multiple processing chamber set and use thereof
US7651457B2 (en) 2003-08-04 2010-01-26 Zymequest, Inc. Expandable processing and expression chamber
US20050113237A1 (en) * 2003-11-25 2005-05-26 Keith Rosiello Integral seal for centrifuge chamber
US9510617B2 (en) 2012-04-13 2016-12-06 Frito-Lay North America, Inc. Micropellets of fine particle nutrients and methods of incorporating same into snack food products
US9271523B2 (en) * 2012-05-23 2016-03-01 Dennis Williams Rotor assembly with one-piece finger member
US9955712B2 (en) 2014-11-11 2018-05-01 Frito-Lay North America, Inc. Rotary head extruder
US9669574B2 (en) 2014-11-11 2017-06-06 Frito-Lay North America, Inc. Twin screw rotary head extruder, method of extrusion and random extruded products
JP6706692B2 (en) * 2017-01-10 2020-06-10 富士フイルム株式会社 Rotary joint and centrifuge
CN112175827B (en) * 2020-09-25 2023-09-12 深圳赛桥生物创新技术有限公司 Automatic cell centrifugal cleaning and liquid changing method and device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2906453A (en) * 1959-09-29 Washing centrifuge
US2178322A (en) * 1938-12-03 1939-10-31 W C Norris Mfg Inc Power take-off
UST955355I4 (en) * 1959-06-24 1900-01-01
US3347454A (en) * 1964-05-13 1967-10-17 Baxter Laboratories Inc Method and apparatus for the centrifugal washing of particles in a closed system
US3442559A (en) * 1966-03-14 1969-05-06 Reliance Electric & Eng Co Take-up bearing support

Also Published As

Publication number Publication date
BE728823A (en) 1969-08-01
SE357308B (en) 1973-06-25
GB1259790A (en) 1972-01-12
US3719406A (en) 1973-03-06
DE1912920A1 (en) 1969-10-09
US3561672A (en) 1971-02-09
NL6904083A (en) 1969-09-22
FR2004135A1 (en) 1969-11-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee