GB1240786A - Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes - Google Patents

Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes

Info

Publication number
GB1240786A
GB1240786A GB60432/69A GB6043269A GB1240786A GB 1240786 A GB1240786 A GB 1240786A GB 60432/69 A GB60432/69 A GB 60432/69A GB 6043269 A GB6043269 A GB 6043269A GB 1240786 A GB1240786 A GB 1240786A
Authority
GB
United Kingdom
Prior art keywords
mercury
radioactive
compounds
compound
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB60432/69A
Inventor
Josef Ratusky
Leo Kronrad
Prokop Malek
Jiri Kolc
Bohuslav Vavrejn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Publication of GB1240786A publication Critical patent/GB1240786A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1,240,786. Radioactive difluoresceinyl-mercury compounds. CESKOSLOVENSKA AKADEMIE VEB. 11 Dec., 1969 [20 Dec., 1968], No. 60432/69. Heading C2J. In difluoresceinyl-mercury compounds of Formalµ (Ia) or (Ib) (where R=H or halogen and R<SP>1</SP>-R<SP>5</SP> = H, halogen, alkyl or HgX, where X is an anion) at least one of R and R<SP>1</SP>-R<SP>5</SP> is radioactive iodine. The mercury atom need not be radioactive. The compounds may be prepared by reacting a suspension of the corresponding fluorescein derivative with a solution of an ionic bivalent mercury compound, e.g. mercuric acetate, whereby the mercury atom is substituted in two stages. The desired compound is separated by chromatography. The following compounds are disclosed, having labelling <SP>125</SP>I, <SP>131</SP>I, <SP>125</SP>I<SP>203</SP>Hg, <SP>125</SP>I<SP>197</SP>Hg, <SP>131</SP>I<SP>203</SP>Hg or <SP>131</SP>I<SP>197</SP>Hg: bis-4<SP>1</SP>-(2<SP>1</SP>,7<SP>1</SP>-diiodofluoresceinyl) mercury, bis - 21 - (4<SP>1</SP>,5<SP>1</SP>- diiodofluoresceinyl) mercury and bis-(tetraiodofluoresceinyl) mercury. The chromatographic fractions can contain the pure compound or a mixture thereof with the hydroxymercuryfluorescein compound.
GB60432/69A 1968-12-20 1969-12-11 Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes Expired GB1240786A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS866368 1968-12-20

Publications (1)

Publication Number Publication Date
GB1240786A true GB1240786A (en) 1971-07-28

Family

ID=5437489

Family Applications (1)

Application Number Title Priority Date Filing Date
GB60432/69A Expired GB1240786A (en) 1968-12-20 1969-12-11 Process of manufacturing radioactive substances derived from difluorescenylmercury and labelled with radioactive iodin isotopes

Country Status (8)

Country Link
BE (1) BE743230A (en)
BR (1) BR6915452D0 (en)
DE (1) DE1964100A1 (en)
ES (1) ES374647A1 (en)
FR (1) FR2104724B1 (en)
GB (1) GB1240786A (en)
NL (1) NL6918943A (en)
ZA (1) ZA698810B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008003954A1 (en) * 2006-07-05 2008-01-10 Ge Healthcare Limited Dye imaging agents
CN113702342A (en) * 2021-04-21 2021-11-26 苏州科技大学 Method for detecting mercury ions in solution by fluorescence conversion

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008003954A1 (en) * 2006-07-05 2008-01-10 Ge Healthcare Limited Dye imaging agents
CN113702342A (en) * 2021-04-21 2021-11-26 苏州科技大学 Method for detecting mercury ions in solution by fluorescence conversion

Also Published As

Publication number Publication date
ES374647A1 (en) 1972-01-01
BE743230A (en) 1970-05-28
NL6918943A (en) 1970-06-23
FR2104724B1 (en) 1975-01-10
ZA698810B (en) 1971-08-25
FR2104724A1 (en) 1972-04-21
DE1964100A1 (en) 1970-07-02
BR6915452D0 (en) 1973-05-15

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