GB1202110A - Novel quinoline derivatives and their preparation - Google Patents

Novel quinoline derivatives and their preparation

Info

Publication number
GB1202110A
GB1202110A GB5846268A GB5846268A GB1202110A GB 1202110 A GB1202110 A GB 1202110A GB 5846268 A GB5846268 A GB 5846268A GB 5846268 A GB5846268 A GB 5846268A GB 1202110 A GB1202110 A GB 1202110A
Authority
GB
United Kingdom
Prior art keywords
alkyl
general formula
quinoline
group
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5846268A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority to US882722A priority Critical patent/US3622457A/en
Priority to US882723A priority patent/US3692790A/en
Publication of GB1202110A publication Critical patent/GB1202110A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,202,110. Quinoline derivatives. STERLING DRUG Inc. 9 Dec., 1968 [15 Dec., 1967], No. 58462/68. Heading C2C. Novel quinoline derivatives of the general formula wherein X is a halogen atom, R is a hydrogen atom or a C 1-6 alkyl or C 1-6 alkanoyl group, Y is a C 2-6 alkylene group, R 1 is a hydrogen atom or a C 1-6 alkyl or 2-hydroxyl-C 2-6 -alkyl group R 2 is a C 1-6 alkyl or 2-hydroxy-C 2-6 alkyl group, or R 1 and R 2 , together with the nitrogen atom to which they are attached, form a 5-7 membered saturated monocyclic radical, and acid addition salts thereof are prepared (a) by reduction of an alkyl 5-aminoalkylamino-quinoline-8-carboxylate of the general formula wherein R<SP>1</SP> is a C 1-6 alkyl group; (b) when Y is an ethylene group, by reduction of an alkyl 5-aminoacetamido-quinoline-8-carboxylate of the general formula or (c) by subjection of a 5-(R 1 R 2 N-Y-NH)-6 or 7-halo-8-methylquinoline to the fermentative enzymatic action of a micro-organism of the order Moniliales, Mucorales, Sphaeriaeles, Sphaeropsidales, Melanconiales or Antinomycetales; followed optionally by reaction of the resulting quinoline derivative of the first general formula above wherein R is a hydrogen atom with a C 1-6 alkanol in the presence of an acid or with a C 1-6 alkanoyl halide, anhydride or other C 1-6 alkanoylating agent; and/or followed optionally by salification. Pharmaceutical compositions having schistosomacidal activity comprise, as active ingredient, a quinoline derivative of the first general formula above or an acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally or parenterally.
GB5846268A 1967-12-15 1968-12-09 Novel quinoline derivatives and their preparation Expired GB1202110A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US882722A US3622457A (en) 1968-12-09 1969-12-05 Process for preparing 5-(aminoalkylamino)-6 (or 7)-halo-8-quinoline methanols
US882723A US3692790A (en) 1968-12-09 1969-12-05 5-(aminoalkylamino)-6(or)-halo-8-quinolinemethanols, their alkyl ethers and alkanoyl esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69079567A 1967-12-15 1967-12-15

Publications (1)

Publication Number Publication Date
GB1202110A true GB1202110A (en) 1970-08-12

Family

ID=24774005

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5846268A Expired GB1202110A (en) 1967-12-15 1968-12-09 Novel quinoline derivatives and their preparation

Country Status (2)

Country Link
BR (1) BR6804817D0 (en)
GB (1) GB1202110A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104389A2 (en) * 1982-09-07 1984-04-04 BASF Aktiengesellschaft Quinoline derivatives, process for their preparation and their use in the control of undesired plant growth
US5932401A (en) * 1997-08-21 1999-08-03 Eastman Kodak Company Reversal photographic elements comprising an additional layer containing an imaging emulsion and a non-imaging emulsion

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104389A2 (en) * 1982-09-07 1984-04-04 BASF Aktiengesellschaft Quinoline derivatives, process for their preparation and their use in the control of undesired plant growth
EP0104389A3 (en) * 1982-09-07 1984-10-10 Basf Aktiengesellschaft Quinoline derivatives, process for their preparation and their use in the control of undesired plant growth
US4715889A (en) * 1982-09-07 1987-12-29 Basf Aktiengesellschaft Quinoline derivatives and their use for controlling undesirable plant growth
US5932401A (en) * 1997-08-21 1999-08-03 Eastman Kodak Company Reversal photographic elements comprising an additional layer containing an imaging emulsion and a non-imaging emulsion

Also Published As

Publication number Publication date
BR6804817D0 (en) 1973-03-08

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees