GB1108756A - Improvements in or relating to tyrosine derivatives - Google Patents
Improvements in or relating to tyrosine derivativesInfo
- Publication number
- GB1108756A GB1108756A GB3976/66A GB397666A GB1108756A GB 1108756 A GB1108756 A GB 1108756A GB 3976/66 A GB3976/66 A GB 3976/66A GB 397666 A GB397666 A GB 397666A GB 1108756 A GB1108756 A GB 1108756A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- alkyl
- formula
- hydroxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003667 tyrosine derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 abstract 1
- SGQXQKMSXUGTJE-UHFFFAOYSA-N 1-(4-hydroxy-3-methylphenyl)propan-2-one Chemical compound CC(=O)CC1=CC=C(O)C(C)=C1 SGQXQKMSXUGTJE-UHFFFAOYSA-N 0.000 abstract 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 abstract 1
- 239000001099 ammonium carbonate Substances 0.000 abstract 1
- 235000012501 ammonium carbonate Nutrition 0.000 abstract 1
- 229940025084 amphetamine Drugs 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract 1
- 229940091173 hydantoin Drugs 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
<FORM:1108756/C2/1> <FORM:1108756/C2/2> Novel 3,a -dialkyltyrosine esters of the Formula I, wherein R is C1- 3 alkyl, R1 is C1- 4 alkyl an R2 is C1- 2 alkyl, and their acid-addition salts, are prepared by condensing a compound of the Formula II, or a salt thereof, with a compound of the formula Y-R1, wherein X and Y are atoms or groups which react together to form an ester linkage, and optionally converting the product into an acid-addition salt. 3,a - Dimethyltyrosine is prepared by reacting 4 - hydroxy - 3 - methylphenylacetone with sodium cyanide and ammonium carbonate to form 5 - methyl - 5 - (41 - hydroxy - 31 - methyl-benzyl) hydantoin and hydrolysing this compound in the presence of sodium hydroxide. Pharmaceutical compositions, which have antihypertensive and antipyretic activity and which are also capable of blocking the alerting effects of amphetamine, for oral, parenteral or topical administration, comprise a compound of the invention together with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1166/65A SE345849B (en) | 1965-01-29 | 1965-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1108756A true GB1108756A (en) | 1968-04-03 |
Family
ID=20257698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3976/66A Expired GB1108756A (en) | 1965-01-29 | 1966-01-28 | Improvements in or relating to tyrosine derivatives |
Country Status (6)
Country | Link |
---|---|
CH (1) | CH476684A (en) |
DE (1) | DE1543296A1 (en) |
FR (1) | FR5222M (en) |
GB (1) | GB1108756A (en) |
NL (1) | NL6601045A (en) |
SE (1) | SE345849B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4271187A (en) * | 1978-06-05 | 1981-06-02 | Merck & Co., Inc. | Substituted phenyl alanine antihypertensive agents |
CN113302176A (en) * | 2018-12-06 | 2021-08-24 | 先达生物科技公司 | Decarboxylase inhibitors for the treatment of parkinson's disease |
-
1965
- 1965-01-29 SE SE1166/65A patent/SE345849B/xx unknown
-
1966
- 1966-01-20 DE DE19661543296 patent/DE1543296A1/en active Pending
- 1966-01-27 NL NL6601045A patent/NL6601045A/xx unknown
- 1966-01-28 FR FR47680A patent/FR5222M/fr not_active Expired
- 1966-01-28 GB GB3976/66A patent/GB1108756A/en not_active Expired
- 1966-01-31 CH CH127466A patent/CH476684A/en not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4271187A (en) * | 1978-06-05 | 1981-06-02 | Merck & Co., Inc. | Substituted phenyl alanine antihypertensive agents |
CN113302176A (en) * | 2018-12-06 | 2021-08-24 | 先达生物科技公司 | Decarboxylase inhibitors for the treatment of parkinson's disease |
EP3891122A4 (en) * | 2018-12-06 | 2022-10-05 | Senda Biosciences, Inc. | Decarboxylase inhibitors for treating parkinson's disease |
Also Published As
Publication number | Publication date |
---|---|
DE1543296A1 (en) | 1969-08-28 |
NL6601045A (en) | 1966-08-01 |
CH476684A (en) | 1969-08-15 |
FR5222M (en) | 1967-07-10 |
SE345849B (en) | 1972-06-12 |
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