GB1083936A - Novel carbamates and methods of producing the same - Google Patents
Novel carbamates and methods of producing the sameInfo
- Publication number
- GB1083936A GB1083936A GB53087/65A GB5308765A GB1083936A GB 1083936 A GB1083936 A GB 1083936A GB 53087/65 A GB53087/65 A GB 53087/65A GB 5308765 A GB5308765 A GB 5308765A GB 1083936 A GB1083936 A GB 1083936A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridyl
- formula
- phenyl
- lower alkyl
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of formula <FORM:1083936/C2/1> wherein Ar and Ar1 when taken separately are phenyl, tolyl, monohalophenyl, xenyl, trifluoromethylphenyl, a -naphthyl, b -naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, a -thienyl, b -thienyl, a -furyl, or b -furyl, or Ar and Ar1 when taken together with the carbon atom to which they are attached are 9-fluoroenyl, 9,10-dihydroanthracen - 9 - yl, 10,11 - dihydro - 5H-dibenzo - [a,d] - cyclohepten - 5 - yl, or 5H-dibenzo - [a,d] - cyclohepten - 5 - yl; R1 and R2 when taken together with the nitrogen atom to which they are attached are aziridino, azetidino, pyrrolidino, piperidino, piperazino, morpholino or thiomorpholino or a radical of formula <FORM:1083936/C2/2> and R1 and R2 when taken separately, and R4 are hydrogen, C1- 6 alkyl, C1- 6 hydroxyalkyl, di - lower - alkylamino - lower alkyl, C3- 6 alkenyl, C3- 6 alkynyl, or C3- 6 cycloalkyl, and Z is a radical of formula -CC-R3 or -CH = CH-R3 where R3 is hydrogen, halo, phenyl, a -naphthyl, b -naphthyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, a -thienyl, b -thienyl, a -furyl, b -furyl, lower alkoxy-lower alkyl, lower alkyl-mercapto, lower alkylmercapto-lower alkyl, lower alkylamino-lower alkyl or di-lower alkylamino-lower alkyl, are prepared by carbamylating a substituted tertiary propargyl carbinol of formula <FORM:1083936/C2/3> to replace the H atom with a carbamic radical of formula -CONR1R2, and, if desired, catalytically hydrogenating the acetylenic radical to provide the ethylenic radical. Phenyl 1 - (4 - bromophenyl) - 1 - phenyl - 2-propynyl carbonate is prepared by reacting 1-(4 - bromophenyl) - 1 - phenyl - 2 - propyn - 1 - ol with phenyl chloroformate. Therapeutic compositions having activity against certain bacteria and fungi, and malignancies, contain as active ingredient a compound of Formula (I) above.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42167764A | 1964-12-28 | 1964-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1083936A true GB1083936A (en) | 1967-09-20 |
Family
ID=23671568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB53087/65A Expired GB1083936A (en) | 1964-12-28 | 1965-12-14 | Novel carbamates and methods of producing the same |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE674395A (en) |
BR (1) | BR6576024D0 (en) |
CH (1) | CH473096A (en) |
DE (1) | DE1298094B (en) |
FR (2) | FR5015M (en) |
GB (1) | GB1083936A (en) |
NL (1) | NL133303C (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0002679A1 (en) * | 1977-12-15 | 1979-07-11 | Bayer Ag | 1-Halo-1-propyn-3-ols, process for their preparation and their use as fungicides |
EP0066771A1 (en) * | 1981-06-04 | 1982-12-15 | Bayer Ag | 1-Iodo-1-propyn-3-ols, process for their preparation and their use as plant protecting agents |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4066709A (en) * | 1973-08-15 | 1978-01-03 | Richter Gedeon Vegyeszeti Gyar Rt. | α-Ethyny benzhydrols |
-
1965
- 1965-12-14 GB GB53087/65A patent/GB1083936A/en not_active Expired
- 1965-12-23 DE DEE30731A patent/DE1298094B/en active Pending
- 1965-12-24 NL NL6516922A patent/NL133303C/xx active
- 1965-12-27 CH CH1785065A patent/CH473096A/en not_active IP Right Cessation
- 1965-12-28 BR BR176024/65A patent/BR6576024D0/en unknown
- 1965-12-28 FR FR44018A patent/FR5015M/fr not_active Expired
- 1965-12-28 FR FR44068A patent/FR1482849A/en not_active Expired
- 1965-12-28 BE BE674395A patent/BE674395A/xx unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0002679A1 (en) * | 1977-12-15 | 1979-07-11 | Bayer Ag | 1-Halo-1-propyn-3-ols, process for their preparation and their use as fungicides |
EP0066771A1 (en) * | 1981-06-04 | 1982-12-15 | Bayer Ag | 1-Iodo-1-propyn-3-ols, process for their preparation and their use as plant protecting agents |
US4469902A (en) * | 1981-06-04 | 1984-09-04 | Bayer Aktiengesellschaft | 1-Iodoprop-1-yn-3-ols as plant protection agents |
Also Published As
Publication number | Publication date |
---|---|
NL6516922A (en) | 1966-06-29 |
BE674395A (en) | 1966-06-28 |
BR6576024D0 (en) | 1973-10-23 |
NL133303C (en) | 1972-01-17 |
FR5015M (en) | 1967-04-24 |
DE1298094B (en) | 1969-06-26 |
FR1482849A (en) | 1967-06-02 |
CH473096A (en) | 1969-05-31 |
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