GB1068452A - Novel dihydro-dibenzocycloheptene derivatives and a process for the manufacture thereof - Google Patents
Novel dihydro-dibenzocycloheptene derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1068452A GB1068452A GB42566A GB42566A GB1068452A GB 1068452 A GB1068452 A GB 1068452A GB 42566 A GB42566 A GB 42566A GB 42566 A GB42566 A GB 42566A GB 1068452 A GB1068452 A GB 1068452A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- reacting
- represent
- acid addition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of the Formula I wherein R1 and R2 each represent an alkyl or aryl group or R1 and R2 together represent an oxo, imino or thio group; R3 represents an alkyl group and R4 andR5 each represent a halogen atom or a trifluoromethyl, alkyl, alkoxy, alkylthio, acyl, sulphamyl or alkylsulphamyl group and the broken lines denote that the substituents attached thereby are optional, and ketals and acid addition salts thereof, are prepared by reacting a compound of the Formula II with a cyanogen halide, a carbonic acid halide or ester, carbon disulphide or an appropriate aldehyde or ketone and if desired converting the product into an acetal and/or into an acid addition salt. <FORM:1068452/C2/1> <FORM:1068452/C2/2> Hydroxy amines of the Formula II where R3 is present may be prepared by treating the appropriate dibenzocycloheptenone with an agent yielding a hypohalous acid and reacting the resulting 10-hydroxy-11-halo compound with a suitable alkylamine, or, where R3 is present or absent, by reacting the appropriate 10,11 - epoxy - dibenzo - [a,d] - cyclohepten - 5-one with ammonia or an amine. Therapeutic compositions with antidepressant activity, in the forms of tablets, dragees, capsules, suppositories, salves, solutions, suspensions and emulsions for oral, topical or parenteral application comprise compounds of the Formula I, their ketals and acid addition salts, together with a compatible pharmaceutical carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH52565A CH469017A (en) | 1965-01-14 | 1965-01-14 | Process for the preparation of dihydrodibenzocycloheptene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1068452A true GB1068452A (en) | 1967-05-10 |
Family
ID=4188992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42566A Expired GB1068452A (en) | 1965-01-14 | 1966-01-05 | Novel dihydro-dibenzocycloheptene derivatives and a process for the manufacture thereof |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE674991A (en) |
| BR (1) | BR6576114D0 (en) |
| CH (2) | CH469017A (en) |
| DE (1) | DE1545979A1 (en) |
| DK (1) | DK118080B (en) |
| ES (1) | ES321731A1 (en) |
| FR (2) | FR4926M (en) |
| GB (1) | GB1068452A (en) |
| IL (1) | IL24853A (en) |
| NL (1) | NL6600452A (en) |
| SE (1) | SE352640B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4856114A (en) * | 1988-07-27 | 1989-08-15 | Chen Jiann Jong | Seaman style preset necktie |
-
1965
- 1965-01-14 CH CH52565A patent/CH469017A/en unknown
- 1965-01-14 CH CH1404968A patent/CH490406A/en unknown
- 1965-12-21 DE DE19651545979 patent/DE1545979A1/en active Pending
- 1965-12-22 IL IL2485365A patent/IL24853A/en unknown
- 1965-12-30 BR BR17611465A patent/BR6576114D0/en unknown
-
1966
- 1966-01-04 FR FR44694A patent/FR4926M/fr not_active Expired
- 1966-01-05 GB GB42566A patent/GB1068452A/en not_active Expired
- 1966-01-08 FR FR45262A patent/FR1463319A/en not_active Expired
- 1966-01-12 BE BE674991D patent/BE674991A/xx unknown
- 1966-01-12 DK DK15166A patent/DK118080B/en unknown
- 1966-01-13 NL NL6600452A patent/NL6600452A/xx unknown
- 1966-01-13 ES ES0321731A patent/ES321731A1/en not_active Expired
- 1966-01-14 SE SE54066A patent/SE352640B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL24853A (en) | 1969-11-12 |
| DK118080B (en) | 1970-07-06 |
| CH469017A (en) | 1969-02-28 |
| ES321731A1 (en) | 1966-06-16 |
| DE1545979A1 (en) | 1970-01-22 |
| FR4926M (en) | 1967-03-20 |
| FR1463319A (en) | 1966-12-23 |
| CH490406A (en) | 1970-05-15 |
| SE352640B (en) | 1973-01-08 |
| BR6576114D0 (en) | 1973-09-06 |
| BE674991A (en) | 1966-07-12 |
| NL6600452A (en) | 1966-07-15 |
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