GB1061571A - N,n'-disubstituted piperazines and process for their manufacture - Google Patents

N,n'-disubstituted piperazines and process for their manufacture

Info

Publication number
GB1061571A
GB1061571A GB170264A GB170264A GB1061571A GB 1061571 A GB1061571 A GB 1061571A GB 170264 A GB170264 A GB 170264A GB 170264 A GB170264 A GB 170264A GB 1061571 A GB1061571 A GB 1061571A
Authority
GB
United Kingdom
Prior art keywords
acid addition
phenyl
addition salt
converting
free base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB170264A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1061571A publication Critical patent/GB1061571A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of formula <FORM:1061571/C2/1> in which Ar represents a phenyl, (lower alkyl)-phenyl, (lower alkoxy)-phenyl, halogenophenyl or trifluoromethylphenyl group, Ph represents a substituted or unsubstituted phenyl group, m represents 3 or 4, and R1 represents a hydrogen atom or methyl group, and acid addition salts thereof, are prepared by reacting an N-mono-substituted piperazine with a phenoxyalkyl halide, and converting a resulting acid addition salt into a free base, or into another acid addition salt, or converting a resulting free base into an acid addition salt. Therapeutic compositions having anti-inflammatory, anti-hypertensive, tranquillizing, sedative, adrenolytic, anti-histaminic, and anti-fibrillatory properties which may be administered enterally or parenterally contain as active ingredient the compounds of the general formula above, or physiologically tolerable acid addition salts thereof. Reference has been directed by the Comptroller to Specification 984,017.
GB170264A 1963-01-14 1964-01-14 N,n'-disubstituted piperazines and process for their manufacture Expired GB1061571A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25104763A 1963-01-14 1963-01-14
US25778463A 1963-02-11 1963-02-11
US25778363A 1963-02-11 1963-02-11
US27189063A 1963-04-10 1963-04-10
US32134263A 1963-11-04 1963-11-04
US32133463A 1963-11-04 1963-11-04

Publications (1)

Publication Number Publication Date
GB1061571A true GB1061571A (en) 1967-03-15

Family

ID=27559375

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1053301D Active GB1053301A (en) 1963-01-14
GB170264A Expired GB1061571A (en) 1963-01-14 1964-01-14 N,n'-disubstituted piperazines and process for their manufacture

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1053301D Active GB1053301A (en) 1963-01-14

Country Status (5)

Country Link
BE (3) BE642428A (en)
CH (5) CH449634A (en)
DE (1) DE1232587B (en)
FR (1) FR3734M (en)
GB (2) GB1061571A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034284A2 (en) * 1980-02-18 1981-08-26 Tanabe Seiyaku Co., Ltd. Piperazine derivative, processes for preparing the same and therapeutic compositions containing it
US7485651B2 (en) 1998-03-31 2009-02-03 Acadia Pharmaceuticals, Inc. Compounds with activity on muscarinic receptors

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5513209A (en) * 1978-07-11 1980-01-30 Synthelabo Antidepressive made of piperazine derivative
FR2568878B1 (en) * 1984-08-07 1986-11-21 Cortial NOVEL (PHENYLPIPERAZINYLETHYLAMINE ETHOXY) -4 PHENOL DERIVATIVES, THEIR PREPARATION METHOD AND THEIR THERAPEUTIC APPLICATION
DE3715763A1 (en) * 1987-05-12 1988-11-24 Hoechst Ag DIARYLALKYL-SUBSTITUTED ALKYLAMINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND MEDICINAL PRODUCTS CONTAINING THE SAME
KR100672186B1 (en) * 1998-03-31 2007-01-19 아카디아 파마슈티칼스 인코포레이티드 Compounds with activity on muscarinic receptors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034284A2 (en) * 1980-02-18 1981-08-26 Tanabe Seiyaku Co., Ltd. Piperazine derivative, processes for preparing the same and therapeutic compositions containing it
EP0034284A3 (en) * 1980-02-18 1981-12-09 Tanabe Seiyaku Co., Ltd. Piperazine derivative and processes for preparing the same
US7485651B2 (en) 1998-03-31 2009-02-03 Acadia Pharmaceuticals, Inc. Compounds with activity on muscarinic receptors

Also Published As

Publication number Publication date
BE642429A (en) 1964-07-13
GB1053301A (en)
DE1232587B (en) 1967-01-19
CH449633A (en) 1968-01-15
BE642428A (en) 1964-07-13
CH449635A (en) 1968-01-15
CH449634A (en) 1968-01-15
CH449030A (en) 1967-12-31
BE642427A (en) 1964-07-13
FR3734M (en) 1965-12-06
CH449636A (en) 1968-01-15

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