GB1057471A - Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof - Google Patents

Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof

Info

Publication number
GB1057471A
GB1057471A GB12628/64A GB1262864A GB1057471A GB 1057471 A GB1057471 A GB 1057471A GB 12628/64 A GB12628/64 A GB 12628/64A GB 1262864 A GB1262864 A GB 1262864A GB 1057471 A GB1057471 A GB 1057471A
Authority
GB
United Kingdom
Prior art keywords
compounds
benzdiaz
novel
manufacture
lower alkanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12628/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1057471A publication Critical patent/GB1057471A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of the general formula <FORM:1057471/C2/1> (wherein R represents a lower alkanoyl or benzoyl group or a hydrogen atom, the lower alkanoyl and lower alkyl groups each contain 1-7 carbon atoms and the broken lines denote optional substituents) and their acid addition salts are prepared by subjecting a compound of the formula <FORM:1057471/C2/2> to rearrangement-cum-acylation by treatment with a C1-7 alkanoic acid or benzoic acid or a functional derivative thereof, optionally followed by hydrolysis and/or salt formation. The compounds of the invention are anti-convulsants and may be administered enterally or parenterally in the form of pharmaceutical preparations (e.g. tablets, drag<\>aees, suppositories, capsules, solutions, emulsions and suspensions) containing them, with or without other (unspecified) active ingredients, together with a carrier.
GB12628/64A 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof Expired GB1057471A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26790863A 1963-03-26 1963-03-26

Publications (1)

Publication Number Publication Date
GB1057471A true GB1057471A (en) 1967-02-01

Family

ID=23020651

Family Applications (3)

Application Number Title Priority Date Filing Date
GB12628/64A Expired GB1057471A (en) 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof
GB42651/65A Expired GB1057473A (en) 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof
GB42650/65A Expired GB1057472A (en) 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the preparation thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB42651/65A Expired GB1057473A (en) 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof
GB42650/65A Expired GB1057472A (en) 1963-03-26 1964-03-25 Novel benzdiaz[1,4]epine derivatives and a process for the preparation thereof

Country Status (11)

Country Link
BE (1) BE645624A (en)
BR (1) BR6457465D0 (en)
CH (1) CH461514A (en)
DE (3) DE1695155A1 (en)
DK (1) DK106911C (en)
ES (1) ES298037A1 (en)
FR (1) FR3276M (en)
GB (3) GB1057471A (en)
IL (2) IL27973A (en)
NL (1) NL6403187A (en)
SE (3) SE312340B (en)

Also Published As

Publication number Publication date
SE329171B (en) 1970-10-05
BR6457465D0 (en) 1973-07-17
GB1057473A (en) 1967-02-01
CH461514A (en) 1968-08-31
GB1057472A (en) 1967-02-01
DE1695154A1 (en) 1970-07-16
DE1445890A1 (en) 1969-02-06
BE645624A (en) 1964-09-24
IL20920A (en) 1968-07-25
FR3276M (en) 1965-04-26
DK106911C (en) 1967-04-03
IL27973A (en) 1968-07-25
DE1695155A1 (en) 1970-07-16
NL6403187A (en) 1964-09-28
SE329628B (en) 1970-10-19
ES298037A1 (en) 1964-09-01
SE312340B (en) 1969-07-14

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