GB1055926A - A novel class of steroid compounds - Google Patents
A novel class of steroid compoundsInfo
- Publication number
- GB1055926A GB1055926A GB921064A GB921064A GB1055926A GB 1055926 A GB1055926 A GB 1055926A GB 921064 A GB921064 A GB 921064A GB 921064 A GB921064 A GB 921064A GB 1055926 A GB1055926 A GB 1055926A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- subjected
- ring structure
- action
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel steroid compounds of the formulae <FORM:1055926/C2/1> wherein St represents the substituted or unsubstituted androstane configuration, R3 represents a hydrogen atom and R4 represents an alkyl aryl, or aralkyl group or R3 and R4 each represent an alkyl, aryl, or aralkyl group or together with the nitrogen atom represent a cyclic ring structure incorporating these three groups and optionally substituted within the ring structure, R represents a hydrogen atom or the residue of a carboxylic acid and Y represents the oxygen atom of a keto group or two hydrogen atoms are obtained in a process in which a 21,22-dicarboxylic pregnane of the general formula <FORM:1055926/C2/2> is subjected to the action of a chlorinating agent to form the corresponding 21,22-di-(acid chloride) derivative which is then reacted with an amine of the general formula <FORM:1055926/C2/3> to form the corresponding diamide which is then subjected to the action of an alkali metal aluminium hydride to yield a desired compound which is optionally thereafter acylated at the 3-position and/or oxidized at the 11-position and/or salified as desired. Pharmaceutical compositions having vasodilative and spasmolytic activity are administered orally, parenterally or rectally.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR926732A FR1453206A (en) | 1963-03-04 | 1963-03-04 | Diamino steroids and method of preparation |
FR933956A FR2810M (en) | 1963-03-04 | 1963-05-07 | New drug in particular for the treatment of spasms of coronary or visceral origin. |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1055926A true GB1055926A (en) | 1967-01-18 |
Family
ID=26200070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB921064A Expired GB1055926A (en) | 1963-03-04 | 1964-03-04 | A novel class of steroid compounds |
GB3723866A Expired GB1055927A (en) | 1963-03-04 | 1964-03-04 | 24-nor-5-ß-cholane steroids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3723866A Expired GB1055927A (en) | 1963-03-04 | 1964-03-04 | 24-nor-5-ß-cholane steroids |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH429719A (en) |
DK (1) | DK115471B (en) |
GB (2) | GB1055926A (en) |
-
1964
- 1964-02-18 CH CH195964A patent/CH429719A/en unknown
- 1964-03-02 DK DK103364A patent/DK115471B/en unknown
- 1964-03-04 GB GB921064A patent/GB1055926A/en not_active Expired
- 1964-03-04 GB GB3723866A patent/GB1055927A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK115471B (en) | 1969-10-13 |
CH429719A (en) | 1967-02-15 |
GB1055927A (en) | 1967-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1064284A (en) | Improvements in or relating to progesterone derivatives | |
GB1048231A (en) | New steroid compounds, compositions incorporating them and processes for their preparation | |
GB1033777A (en) | Bis-anilide derivatives | |
GB1055926A (en) | A novel class of steroid compounds | |
GB1504694A (en) | Benzo-bicyclononene derivatives | |
GB1110792A (en) | Novel 5(10)-dehydro-steroids | |
GB1093125A (en) | Improvements in or relating to new and therapeutically active derivatives of 1,2-cyclopentanoperhydrophen-anthrene | |
GB1060791A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB1082574A (en) | Steroid esters | |
ES335030A1 (en) | Cyano-derivatives of steroids | |
GB930676A (en) | Process for the preparation of 20-alkylamino steroid derivatives and novel 20-alkylamino steroid derivatives prepared thereby | |
GB1067345A (en) | Novel steroid compounds, processes for preparing them and compositions containing them | |
GB870388A (en) | Steroid compounds and the preparation thereof | |
GB1018780A (en) | Steroid (2,3í¬c) furazan compounds and the process for the production thereof | |
GB970588A (en) | New steroid compounds and processes for their preparation | |
ES293710A1 (en) | Novel steroid compounds, processes for their preparation and compositions containing them | |
GB1120478A (en) | Improvements in or relating to steroids and the manufacture thereof | |
GB1147343A (en) | Improvements in or relating to novel steroids and the manufacture thereof | |
GB979898A (en) | New fused polycyclic hydrocarbon derivatives and processes for the preparation thereof | |
GB870389A (en) | Steroid compounds and the preparation thereof | |
GB1031071A (en) | Novel substituted pregnanes, processes for their preparation and pharmaceutical compositions incorporating them | |
GB983608A (en) | Novel des-a-steroid compounds, and processes for their preparation | |
ES303113A1 (en) | Procedure for preparing steroid ketones and their derivatives. (Machine-translation by Google Translate, not legally binding) | |
GB1056937A (en) | Novel halogenomethyl steroids and processes for their preparation | |
GB870387A (en) | Steroid compounds and the preparation thereof |