GB1017277A - Process for the manufacture of benzodiazepine derivatives - Google Patents
Process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- GB1017277A GB1017277A GB45099/62A GB4509962A GB1017277A GB 1017277 A GB1017277 A GB 1017277A GB 45099/62 A GB45099/62 A GB 45099/62A GB 4509962 A GB4509962 A GB 4509962A GB 1017277 A GB1017277 A GB 1017277A
- Authority
- GB
- United Kingdom
- Prior art keywords
- product
- halogen
- group
- nitro group
- introducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the general formula <FORM:1017277/C2/1> (wherein R1 and R2 each represents a halogen atom or a trifluoromethyl group and the broken lines indicate that the substituents attached thereby are optional) and acid addition salts thereof are prepared by reacting a benzophenone of the formula <FORM:1017277/C2/2> (wherein R3 and R4 each represents an optional halogen, trifluoromethyl or nitro substituent) with ethylene diamine, introducing a nitro group into the reaction product where R4 is absent, replacing said nitro group and/or any nitro group(s) already present in the reaction product by halogen and, if desired, converting the product into an acid addition salt, a methylation step for the purpose of introducing a methyl group in the 1-position in the product being included at any suitable stage if desired.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15698861A | 1961-12-04 | 1961-12-04 | |
US20403462A | 1962-06-21 | 1962-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1017277A true GB1017277A (en) | 1966-01-19 |
Family
ID=26853725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB45099/62A Expired GB1017277A (en) | 1961-12-04 | 1962-11-29 | Process for the manufacture of benzodiazepine derivatives |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE625283A (en) |
CH (2) | CH436315A (en) |
DE (2) | DE1296638B (en) |
ES (1) | ES283029A1 (en) |
GB (1) | GB1017277A (en) |
MY (1) | MY6700025A (en) |
OA (1) | OA02393A (en) |
SE (1) | SE310685B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466799A (en) * | 1994-08-08 | 1995-11-14 | Iowa State University Research Foundation, Inc. | Synthesis of benzodiazepines |
-
1962
- 1962-11-16 CH CH1342862A patent/CH436315A/en unknown
- 1962-11-16 CH CH1295566A patent/CH457461A/en unknown
- 1962-11-19 DE DEH47444A patent/DE1296638B/en active Pending
- 1962-11-26 BE BE625283A patent/BE625283A/en unknown
- 1962-11-29 GB GB45099/62A patent/GB1017277A/en not_active Expired
- 1962-12-03 SE SE12974/62A patent/SE310685B/xx unknown
- 1962-12-03 ES ES283029A patent/ES283029A1/en not_active Expired
-
1967
- 1967-03-30 OA OA52858A patent/OA02393A/en unknown
- 1967-06-08 DE DE19671695192 patent/DE1695192A1/en active Pending
- 1967-12-31 MY MY196725A patent/MY6700025A/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE1695192A1 (en) | 1970-03-19 |
CH436315A (en) | 1967-05-31 |
BE625283A (en) | 1963-05-27 |
DE1296638B (en) | 1969-06-04 |
MY6700025A (en) | 1967-12-31 |
ES283029A1 (en) | 1963-06-01 |
OA02393A (en) | 1970-05-05 |
CH457461A (en) | 1968-06-15 |
SE310685B (en) | 1969-05-12 |
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