GB1006547A - The antibiotic, takamycin, and process for the production of the same - Google Patents
The antibiotic, takamycin, and process for the production of the sameInfo
- Publication number
- GB1006547A GB1006547A GB16461/62A GB1646162A GB1006547A GB 1006547 A GB1006547 A GB 1006547A GB 16461/62 A GB16461/62 A GB 16461/62A GB 1646162 A GB1646162 A GB 1646162A GB 1006547 A GB1006547 A GB 1006547A
- Authority
- GB
- United Kingdom
- Prior art keywords
- takamycin
- antibiotic
- methanol
- ethanol
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
<PICT:1006547/C2/1> The antibiotic Takamycin is obtained by cultivating Streptomyces takataensis or an antibiotic Takanycin - producing mutant thereof in a culture medium containing as essential constituents carbon and nitrogen sources under aerobic conditions and recovering the antibiotic from the mycelium and the culture broth. Preferably the culture medium is liquid, contains inorganic salts and is cultivated at pH 7.0 and 27-30 DEG C. for 3 to 6 days under submerged aerobic conditions. Takamycin is recovered from the mycelium by extraction with methanol, ethanol or acetone, followed by washing with ether or ethyl acetate and recrystallization from aqueous ethanol; and from the culture filtrate by adsorbtion on Japanese acid clay, elution with butanol/pyridine/water, concentrating the eluate, and washing and recrystallizing as above. Takamycin is a yellow crystalline amphoteric substance decomposing at 150 DEG C., soluble in pyridine, dimethylformamide and glacial acetic acid, hardly soluble in diethyl ether; chloroform, petroleum ether and moderately soluble in methanol, ethanol and acetone, particularly at an alkaline pH and insoluble in water at acid and neutral pH; having u.v. maxima at 341, 360, 380 and 405 mm (Img/ 100 ml. of methanol); an I.R. spectrum as shown in Fig. 2; gives negative ninhydrin and o-nitrobenzaldehyde reactions and shows the elemental analysis c = 60.48-59.51%, H = 7.93-7.70% and N = 3.05-2.64%. The antibiotic Takamycin in a vaseline base is used to treat Trycohophyton infections.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1541061 | 1961-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1006547A true GB1006547A (en) | 1965-10-06 |
Family
ID=11887951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16461/62A Expired GB1006547A (en) | 1961-05-04 | 1962-04-30 | The antibiotic, takamycin, and process for the production of the same |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH410286A (en) |
| FR (1) | FR1872M (en) |
| GB (1) | GB1006547A (en) |
-
1962
- 1962-04-30 GB GB16461/62A patent/GB1006547A/en not_active Expired
- 1962-05-03 FR FR896374A patent/FR1872M/en active Active
- 1962-05-03 CH CH528962A patent/CH410286A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH410286A (en) | 1966-03-31 |
| FR1872M (en) | 1963-06-24 |
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