FR3085848B1 - Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale - Google Patents

Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale Download PDF

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Publication number
FR3085848B1
FR3085848B1 FR1858342A FR1858342A FR3085848B1 FR 3085848 B1 FR3085848 B1 FR 3085848B1 FR 1858342 A FR1858342 A FR 1858342A FR 1858342 A FR1858342 A FR 1858342A FR 3085848 B1 FR3085848 B1 FR 3085848B1
Authority
FR
France
Prior art keywords
pharmaceutical composition
mass
topical use
substance
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1858342A
Other languages
English (en)
Other versions
FR3085848A1 (fr
Inventor
Catherine Bulcourt
Alice Denis
Severine Sigurani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Original Assignee
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA filed Critical Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Priority to FR1858342A priority Critical patent/FR3085848B1/fr
Priority to JP2021513240A priority patent/JP2022500377A/ja
Priority to PCT/FR2019/052118 priority patent/WO2020058605A1/fr
Priority to CN201980059400.0A priority patent/CN112689503A/zh
Priority to US17/276,315 priority patent/US20220031707A1/en
Priority to EP19787035.5A priority patent/EP3852719A1/fr
Publication of FR3085848A1 publication Critical patent/FR3085848A1/fr
Application granted granted Critical
Publication of FR3085848B1 publication Critical patent/FR3085848B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composition pharmaceutique à usage topique se présentant sous la forme d'une émulsion de type eau dans huile comprenant pour 100% de sa masse : - de 0,3% à 5% massique d'au moins une substance anesthésiante locale; - de 60 à 90% massique d'une phase aqueuse gélifiée (A1) - de 9,7 % à 35% massique d'une phase grasse (A2) comprenant au moins une huile et un système émulsionnant comprenant une combinaison d'au moins un agent tensioactif émulsionnant (S1) sélectionné parmi les éléments du groupe constitué par les compositions d'alkylpolyglycosides, les compositions d'alkylpolyglycosides et d'alcools gras, et d'au moins un agent tensioactif émulsionnant (S2) sélectionné parmi les éléments du groupe constitué par les esters de polyglycérols, les esters de polyglycérols alcoxylés, les polyhydroxystéarates de polyglycols, les polyhydroxystéarates de polyglycérols, les polyhydroxystéarates de polyglycérols alcoxylés.
FR1858342A 2018-09-17 2018-09-17 Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale Active FR3085848B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR1858342A FR3085848B1 (fr) 2018-09-17 2018-09-17 Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale
JP2021513240A JP2022500377A (ja) 2018-09-17 2019-09-12 少なくとも１種の局所麻酔物質を含む局所使用のための医薬組成物
PCT/FR2019/052118 WO2020058605A1 (fr) 2018-09-17 2019-09-12 Composition pharmaceutique à usage topique comprenant au moins une substance anesthésiante locale
CN201980059400.0A CN112689503A (zh) 2018-09-17 2019-09-12 包含至少一种局部麻醉物质的用于局部使用的药物组合物
US17/276,315 US20220031707A1 (en) 2018-09-17 2019-09-12 Pharmaceutical composition for topical use comprising at least one local anaesthetic substance
EP19787035.5A EP3852719A1 (fr) 2018-09-17 2019-09-12 Composition pharmaceutique à usage topique comprenant au moins une substance anesthésiante locale

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1858342A FR3085848B1 (fr) 2018-09-17 2018-09-17 Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale
FR1858342 2018-09-17

Publications (2)

Publication Number Publication Date
FR3085848A1 FR3085848A1 (fr) 2020-03-20
FR3085848B1 true FR3085848B1 (fr) 2020-09-18

Family

ID=65243732

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1858342A Active FR3085848B1 (fr) 2018-09-17 2018-09-17 Composition pharmaceutique a usage topique comprenant au moins une substance anesthesiante locale

Country Status (6)

Country Link
US (1) US20220031707A1 (fr)
EP (1) EP3852719A1 (fr)
JP (1) JP2022500377A (fr)
CN (1) CN112689503A (fr)
FR (1) FR3085848B1 (fr)
WO (1) WO2020058605A1 (fr)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104878D0 (en) * 1991-03-08 1991-04-24 Scott Bader Co Thickeners for personal care products
FR2721607B1 (fr) 1994-06-28 1996-10-31 Seppic Sa Nouveaux dérivés d'ammoniums quaternaires, leur procédé de préparation et leur utilisation comme agents de surface.
SE9704031D0 (sv) * 1997-11-05 1997-11-05 Astra Ab Novel formulation
JP5307309B2 (ja) * 1999-09-03 2013-10-02 ゼリア新薬工業株式会社 吉草酸酢酸プレドニゾロン及び塩基性局所麻酔薬を配合した外用剤
FR2852257B1 (fr) * 2003-03-14 2006-07-21 Emulsions eau-dans-huile, a forte teneur en phase aqueuse, obtenues par un procede simple et economique
FR2852258B1 (fr) * 2003-03-14 2006-07-21 Emulsions notamment solaires de type eau-dans-huile, et leur procede de preparation
FR2912651A1 (fr) 2007-02-21 2008-08-22 Oreal Emulsion e/h pour le soin de la peau.
AU2010351562B2 (en) * 2010-04-21 2013-10-10 Teikoku Pharma Usa, Inc. Local anesthetic emulsion compositions and methods of making and using the same
FR3004454B1 (fr) * 2013-04-12 2015-03-27 Seppic Sa Nouvelles emulsions eau-dans-huile a forte teneur en phase aqueuse, de consistances liquides et stables au stockage
WO2015161378A1 (fr) * 2014-04-22 2015-10-29 Intelactive S.A. Émulsifiants dotés de propriétés de stabilisation d'eau-dans-huile et compositions, utilisations et procédés associés à ceux-ci
FR3057771A1 (fr) * 2016-10-26 2018-04-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Emulsions topiques de lidocaine et d'acides gras utiles en tant qu'analgesique, antalgique ou retardant sexuel

Also Published As

Publication number Publication date
CN112689503A (zh) 2021-04-20
FR3085848A1 (fr) 2020-03-20
EP3852719A1 (fr) 2021-07-28
JP2022500377A (ja) 2022-01-04
WO2020058605A1 (fr) 2020-03-26
US20220031707A1 (en) 2022-02-03

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