FR2961691A1 - Dermatological composition, useful e.g. to maintain and repair skin, and to treat irritation and lesions of dry skin, comprises alpha tocopherol, beta, gamma or delta tocopherol, Vaseline, and zinc in the form of sulfate, chloride or oxide - Google Patents

Dermatological composition, useful e.g. to maintain and repair skin, and to treat irritation and lesions of dry skin, comprises alpha tocopherol, beta, gamma or delta tocopherol, Vaseline, and zinc in the form of sulfate, chloride or oxide Download PDF

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Publication number
FR2961691A1
FR2961691A1 FR1002621A FR1002621A FR2961691A1 FR 2961691 A1 FR2961691 A1 FR 2961691A1 FR 1002621 A FR1002621 A FR 1002621A FR 1002621 A FR1002621 A FR 1002621A FR 2961691 A1 FR2961691 A1 FR 2961691A1
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Prior art keywords
tocopherol
zinc
vaseline
skin
chloride
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Granted
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FR1002621A
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French (fr)
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FR2961691B1 (en
Inventor
Gilles Andre Yves Bhat
Jerome Didier Marc Grapinet
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Dermatological composition comprises alpha tocopherol, and beta , gamma or delta tocopherol and their mixtures and derivatives, Vaseline(RTM: Petroleum jelly), zinc in the form of sulfate, chloride or oxide, where the tocopherol is present in the form of alpha -tocopherol acetate. ACTIVITY : Dermatological; Vulnerary; Antiinflammatory. MECHANISM OF ACTION : None given.

Description

-1- La présente invention concerne une nouvelle composition dermatologique à usage topique, son procédé de fabrication et ses applications. De façon très courante, le tocophérol (vitamine E) est utilisé à des doses faibles en tant que conservateur du fait de son très puissant pouvoir antioxydant. The present invention relates to a new dermatological composition for topical use, its manufacturing process and its applications. Very commonly, tocopherol (vitamin E) is used in low doses as a preservative because of its very powerful antioxidant power.

La vaseline est utilisée en chirurgie pour la cicatrisation. Le zinc, sous forme de chlorure, de sulfate ou d'oxyde, est connu pour ses effets anti-inflammatoires et cicatrisants par son implication dans différents métabolismes énergétiques cellulaires, la synthèse des protéines, de certaines hormones et des acides nucléiques. Les demandeurs ont mis au point une nouvelle composition dotée de multiples qualités dans la cicatrisation cutanée et dans l'action anti-inflammatoire topique. Cette composition, tocophérol associé à de la vaseline et du zinc, présente des propriétés complémentaires dans la réparation cutanée. Par l'expression « tocophérol »on entend non seulement l'a tocophérol mais également le P, x ou le S tocophérol ainsi que leur mélanges et leurs dérivés, qu'ils proviennent de synthèse ou d'extraction naturelle. Parmi ceux-ci on peut citer les esters de tocophérol tel que l'acétate d'alpha tocophérol qui représente l'activité biologique la plus importante. Les demandeurs retiendront l'a tocophérol acétate (qui est la forme la plus active) comme dérivé de tocophérol associé à la vaseline et au zinc, mais de façon nullement limitative en référence aux différentes formes de tocophérol citées ci-dessus. Le zinc peut être sous forme de chlorure, de sulfate ou d'oxyde. Vaseline is used in surgery for healing. Zinc, in the form of chloride, sulphate or oxide, is known for its anti-inflammatory and healing effects through its involvement in various cellular energy metabolisms, the synthesis of proteins, certain hormones and nucleic acids. Applicants have developed a new composition with multiple qualities in skin healing and topical anti-inflammatory action. This composition, tocopherol combined with petrolatum and zinc, has complementary properties in cutaneous repair. By the term "tocopherol" is meant not only a tocopherol but also P, x or S tocopherol as well as their mixtures and their derivatives, whether they come from synthesis or natural extraction. Among these, tocopherol esters such as alpha tocopherol acetate, which represents the most important biological activity, may be mentioned. Applicants will retain tocopherol acetate (which is the most active form) as a tocopherol derivative associated with petrolatum and zinc, but in no way limiting with reference to the various forms of tocopherol cited above. The zinc may be in the form of chloride, sulphate or oxide.

Les différents constituants ci-dessus peuvent entrer dans la composition selon l'invention dans des proportions variables. La présente invention renferme pondéralement : De 20 à 90% de tocophérol De 20 à 90 % de vaseline De 0,5à30%de zinc - la teneur en tocophérol acétate dans la composition, qui est comprise entre 20 et 90 % en poids, est de préférence entre 30 et 40 % par rapport au poids total de la composition. -La teneur en vaseline dans la composition, qui est comprise entre 20 et 90 % en poids, est de préférence entre 30 et 40 % par rapport au poids total de la composition. -La teneur en zinc dans la composition, qui est comprise entre 0,5 et 30 %, est de préférence entre 20 et 30% par rapport au poids total de la composition. La composition selon l'invention peut être présentée sous forme de gel, crème, ou toute autre forme usuelle en application topique. Des exemples de réalisation nullement limitatifs sont donnés ci-après pour illustrer l'invention. 35 Exemple 1 : -2- Formulation crème 40 % Tocophérol acétate Vaseline 40 % Zinc 20 % Du poids total de la composition The various constituents above can be used in the composition according to the invention in variable proportions. The present invention contains by weight: From 20 to 90% of tocopherol From 20 to 90% of petrolatum From 0.5 to 30% of zinc - the content of tocopherol acetate in the composition, which is between 20 and 90% by weight, is preferably between 30 and 40% relative to the total weight of the composition. The content of petrolatum in the composition, which is between 20 and 90% by weight, is preferably between 30 and 40% relative to the total weight of the composition. The zinc content in the composition, which is between 0.5 and 30%, is preferably between 20 and 30% relative to the total weight of the composition. The composition according to the invention may be presented in the form of a gel, cream, or any other form customary in topical application. Non-limiting exemplary embodiments are given below to illustrate the invention. Example 1: Cream Formulation 40% Tocopherol Acetate Vaseline 40% Zinc 20% Total Weight of Composition

Exemple 2 : Autre formulation crème Tocophérol acétate 50 % Vaseline 20 % Zinc 30 % Du poids total de la composition Example 2: Other cream formulation Tocopherol acetate 50% Vaseline 20% Zinc 30% of the total weight of the composition

Exemple 4 : Formulation gel pour sites muqueux Tocophérol acétate 79,5 % Vaseline 20 % Zinc 0,5 % Du poids total de la composition Cette composition dermatologique, objet de la présente invention à base de tocophérol acétate, de vaseline et de zinc est utilisable en thérapeutique. Elle est présentée sous forme administrable par voie topique et est destinée au traitement de pathologies dermatologiques en particulier pour réduire le temps de cicatrisation post traumatique ou chirurgical et dans des syndromes inflammatoires cutanés. -le tocophérol acétate (vitamine E) a des propriétés anti-oxydantes, anti-inflammatoires et hydratantes. Il a un fort pouvoir d'absorption (lors de l'application de tocophérol acétate sur la surface de la peau on retrouve 24 heures après 22% de tocophérol dans le derme). Cela lui confère des propriétés dermatologiques intéressantes en raccourcissant le temps de réparation cutané. De plus, par son action antioxydant très puissante, il est à lui seul un conservateur. Il est à l'état pur comestible et a une période de conservation de 12 mois après ouverture sans adjonction de conservateurs pour une concentration minimale de 50% de la composition finale. Le zinc est un antibactérien puissant déterminant pour son rôle anti-inflammatoire. La nouvelle composition sera donc utilisable sans addition d'aucun conservateur. La vaseline est couramment utilisée en chirurgie, comme lubrifiant vaginal ou comme additif alimentaire(E 905b). Le zinc, sous forme de sulfate, sera associé au tocophérol et a la vaseline a une dose de 0,5% à 3% pour une utilisation réparatrice de sites cutanéo- muqueux sans toxicité. La vaseline est utilisée pour son action dans le traitement d'appoint des 2961691 -3- lésions d'irritation et de sécheresse cutanée. Elle est aussi utilisée comme lubrifiant des muqueuses vaginales sans toxicité. La vaseline, qui est utilisée en chirurgie en couche épaisse, a pour but de protéger une plaie, de ramollir les sécrétions et d'empêcher la formation de croutes. EXAMPLE 4 Gel Formulation for Mucous Sites Tocopherol Acetate 79.5% Vaseline 20% Zinc 0.5% of the total weight of the composition This dermatological composition, object of the present invention based on tocopherol acetate, petrolatum and zinc is usable in therapy. It is presented in topically administrable form and is intended for the treatment of dermatological pathologies, in particular for reducing the post-traumatic or surgical healing time and in inflammatory skin syndromes. tocopherol acetate (vitamin E) has antioxidant, anti-inflammatory and moisturizing properties. It has a high absorption capacity (when applying tocopherol acetate on the surface of the skin is found 24 hours after 22% of tocopherol in the dermis). This gives it interesting dermatological properties by shortening the skin repair time. In addition, by its very powerful antioxidant action, it is in itself a preservative. It is in the pure edible state and has a shelf life of 12 months after opening without the addition of preservatives for a minimum concentration of 50% of the final composition. Zinc is a powerful antibacterial determinant for its anti-inflammatory role. The new composition will therefore be usable without the addition of any preservative. Vaseline is commonly used in surgery, as a vaginal lubricant or as a food additive (E 905b). Zinc, in the form of sulphate, will be combined with tocopherol and petrolatum at a dose of 0.5% to 3% for restorative repair of mucocutaneous sites without toxicity. Petrolatum is used for its action in the adjunctive treatment of irritation and dry skin lesions. It is also used as lubricant vaginal mucosa without toxicity. Vaseline, which is used in thick-layer surgery, is intended to protect a wound, soften secretions and prevent the formation of crusts.

Claims (3)

REVENDICATIONS1) Une composition dermatologique caractérisée en ce qu'elle comprend de l'a tocophérol mais également du (3, x ou du 8 tocophérol ainsi que leur mélanges et leurs dérivés dont l'acétate d'alpha tocophérol, associé à de la vaseline et à du zinc sous forme de sulfate, de chlorure ou d'oxyde. CLAIMS1) A dermatological composition characterized in that it comprises a tocopherol but also (3, x or 8 tocopherol as well as their mixtures and their derivatives including alpha tocopherol acetate, combined with petrolatum and to zinc in the form of sulphate, chloride or oxide. 2) Une composition dermatologique selon la revendication 1, caractérisée en ce qu'elle renferme pondéralement : - De 20 à 90% de tocophérol - De 20 à 90 % de vaseline - De0,5à30%de zinc 2) A dermatological composition according to claim 1, characterized in that it contains by weight: - from 20 to 90% of tocopherol - from 20 to 90% of petrolatum - from 0.5 to 30% of zinc 3) Composition selon l'une quelconque des revendications précédentes, caractérisé en ce qu'elle est 10 administrée sous forme de crème, de gel ou toute autre forme usuelle en application topique. 3) Composition according to any one of the preceding claims, characterized in that it is administered in the form of cream, gel or any other form customary in topical application.
FR1002621A 2010-06-23 2010-06-23 NOVEL DERMATOLOGICAL COMPOSITION ASSOCIATED WITH TOCOPHEROL, VASELINE AND ZINC IN TOPICAL USE Expired - Fee Related FR2961691B1 (en)

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FR1002621A FR2961691B1 (en) 2010-06-23 2010-06-23 NOVEL DERMATOLOGICAL COMPOSITION ASSOCIATED WITH TOCOPHEROL, VASELINE AND ZINC IN TOPICAL USE

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FR1002621A FR2961691B1 (en) 2010-06-23 2010-06-23 NOVEL DERMATOLOGICAL COMPOSITION ASSOCIATED WITH TOCOPHEROL, VASELINE AND ZINC IN TOPICAL USE

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55333A (en) * 1978-06-16 1980-01-05 Fujita Yoshizo Scald ointment
US4551332A (en) * 1981-08-05 1985-11-05 Theodore Stillman Vitamin E compositions and methods
RU2160089C1 (en) * 2000-03-14 2000-12-10 Гройсман Валентина Михайловна Skin disease treatment cream
CN1301538A (en) * 1999-12-28 2001-07-04 张洪冰 Melanin cell growth promotor for external use for skin and producing method thereof
CN1084196C (en) * 1999-02-02 2002-05-08 艾广林 Burn ointment
RU2186561C2 (en) * 2000-08-15 2002-08-10 Иорданиди Наталья Николаевна Cream for dry and normal face skin
CN1365660A (en) * 2001-01-18 2002-08-28 董殿平 Face-beautifying skin-protecting product
US20040013784A1 (en) * 2000-03-16 2004-01-22 Fortunato Costa Additive method of standardized drinks and potable water production
DE102006020481A1 (en) * 2006-04-28 2007-10-31 Nahid Mozayeny Cosmetic and/or dermatological skin care product, useful e.g. to reduce skin aging, comprises a first component containing e.g. allantoin and/or sorbic acid, and a second component containing e.g. petrolatum and/or talc
KR20080074309A (en) * 2007-02-08 2008-08-13 유씨엘 주식회사 Foundation composition that eliminates defects on human skin, returns to natural state, and does not erase in water
CN101313885A (en) * 2008-07-08 2008-12-03 重庆五环富侨保健有限公司 Foot treating massage paste

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55333A (en) * 1978-06-16 1980-01-05 Fujita Yoshizo Scald ointment
US4551332A (en) * 1981-08-05 1985-11-05 Theodore Stillman Vitamin E compositions and methods
CN1084196C (en) * 1999-02-02 2002-05-08 艾广林 Burn ointment
CN1301538A (en) * 1999-12-28 2001-07-04 张洪冰 Melanin cell growth promotor for external use for skin and producing method thereof
RU2160089C1 (en) * 2000-03-14 2000-12-10 Гройсман Валентина Михайловна Skin disease treatment cream
US20040013784A1 (en) * 2000-03-16 2004-01-22 Fortunato Costa Additive method of standardized drinks and potable water production
RU2186561C2 (en) * 2000-08-15 2002-08-10 Иорданиди Наталья Николаевна Cream for dry and normal face skin
CN1365660A (en) * 2001-01-18 2002-08-28 董殿平 Face-beautifying skin-protecting product
DE102006020481A1 (en) * 2006-04-28 2007-10-31 Nahid Mozayeny Cosmetic and/or dermatological skin care product, useful e.g. to reduce skin aging, comprises a first component containing e.g. allantoin and/or sorbic acid, and a second component containing e.g. petrolatum and/or talc
KR20080074309A (en) * 2007-02-08 2008-08-13 유씨엘 주식회사 Foundation composition that eliminates defects on human skin, returns to natural state, and does not erase in water
CN101313885A (en) * 2008-07-08 2008-12-03 重庆五环富侨保健有限公司 Foot treating massage paste

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