FR2960777A1 - Dermatological composition, useful e.g. to maintain and repair skin, and to treat irritation and lesions of dry skin, comprises alpha tocopherol, beta, gamma, or delta tocopherol and Vaseline, where tocopherol is in tocopherol acetate form - Google Patents

Dermatological composition, useful e.g. to maintain and repair skin, and to treat irritation and lesions of dry skin, comprises alpha tocopherol, beta, gamma, or delta tocopherol and Vaseline, where tocopherol is in tocopherol acetate form Download PDF

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Publication number
FR2960777A1
FR2960777A1 FR1002401A FR1002401A FR2960777A1 FR 2960777 A1 FR2960777 A1 FR 2960777A1 FR 1002401 A FR1002401 A FR 1002401A FR 1002401 A FR1002401 A FR 1002401A FR 2960777 A1 FR2960777 A1 FR 2960777A1
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tocopherol
vaseline
dermatological composition
skin
gamma
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Granted
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French (fr)
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FR2960777B1 (en
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Gilles Andre Yves Bhat
Jerome Didier Marc Grapinet
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Dermatological composition comprises alpha tocopherol, and beta , gamma or delta tocopherol and their mixtures and derivatives, and Vaseline(RTM: Petroleum jelly), where the tocopherol is present in the form of tocopherol acetate. ACTIVITY : Dermatological; Antiseborrheic; Virucide; Vulnerary. MECHANISM OF ACTION : None given.

Description

-1- La présente invention concerne une nouvelle composition dermatologique à usage topique, son procédé de fabrication et ses applications. De façon très courante, le tocophérol (vitamine E) est utilisé à des doses faibles en tant que conservateur du fait de son très puissant pouvoir antioxydant. The present invention relates to a new dermatological composition for topical use, its manufacturing process and its applications. Very commonly, tocopherol (vitamin E) is used in low doses as a preservative because of its very powerful antioxidant power.

La vaseline est utilisée en chirurgie pour la cicatrisation. Les demandeurs ont mis au point une nouvelle composition dotée de multiples qualités dans la cicatrisation cutanée après lésion ou en post chirurgical. Cette composition, tocophérol à forte concentration (supérieure ou égale à 50%) associé à de la vaseline, présente des propriétés complémentaires dans la réparation cutanée. Par l'expression « tocophérol »on entend non seulement l'a tocophérol mais également le P, x ou le 8 tocophérol ainsi que leur mélanges et leurs dérivés, qu'ils proviennent de synthèse ou d'extraction naturelle. Parmi ceux-ci on peut citer les esters de tocophérol tel que l'acétate d'alpha tocophérol qui représente l'activité biologique la plus importante. Les demandeurs retiendront l'a tocophérol acétate (qui est la forme la plus active) comme dérivé de tocophérol associé à la vaseline, mais de façon nullement limitative en référence aux différentes formes de tocophérol citées ci-dessus. Dans des conditions préférentielles de mise en oeuvre de l'invention, la composition renferme en outre de l'acide salicylique. Dans encore d'autres conditions préférentielles de mise en oeuvre de l'invention, la composition renferme en outre du cyclopentasiloxane. La composition selon l'invention renferme de préférence 1 de ces composants supplémentaires, notamment 2 de ceux-ci. Les différents constituants ci-dessus peuvent entrer dans la composition selon l'invention dans des proportions variables. Vaseline is used in surgery for healing. The applicants have developed a new composition with multiple qualities in skin healing after injury or post-surgery. This composition, tocopherol at high concentration (greater than or equal to 50%) associated with petroleum jelly, has complementary properties in cutaneous repair. By the term "tocopherol" is meant not only tocopherol but also P, x or tocopherol 8 as well as their mixtures and their derivatives, whether they come from synthesis or natural extraction. Among these, tocopherol esters such as alpha tocopherol acetate, which represents the most important biological activity, may be mentioned. Applicants will retain tocopherol acetate (which is the most active form) as a tocopherol derivative associated with petrolatum, but in no way limiting with reference to the various forms of tocopherol cited above. Under preferred conditions of implementation of the invention, the composition also contains salicylic acid. In still other preferred conditions of implementation of the invention, the composition also contains cyclopentasiloxane. The composition according to the invention preferably contains 1 of these additional components, especially 2 thereof. The various constituents above can be used in the composition according to the invention in variable proportions.

La présente invention renferme pondéralement : De 50 à 90% de tocophérol - De 10 à 50 % de vaseline - De 0,1 à 3 % d'acide salicylique De 10 à 40 % de cyclopentasiloxane - la teneur en tocophérol acétate dans la composition, qui est comprise entre 50 et 90 % en poids, est de préférence entre 70 et 80 % par rapport au poids total de la composition. - La teneur en vaseline dans la composition, qui est comprise entre 10 et 50 % en poids, est de préférence entre 20 et 30 % par rapport au poids total de la composition. - La teneur en acide salicylique dans la composition, qui est comprise entre 0,1 et 0,3 %, est de préférence de 0,3 % par rapport au poids total de la composition. 2960777 -2- Le cyclopentasiloxane peut être mélangé au tocophérol avant la mise en contact de celui-ci à la vaseline pour former une crème plus onctueuse. Sa concentration est comprise entre 10 et 40 %. La composition selon l'invention peut être présentée sous forme de gel, crème, ou toute autre forme usuelle en application topique. 5 Des exemples de réalisation nullement limitatifs sont donnés ci-après pour illustrer l'invention. The present invention contains by weight: from 50 to 90% of tocopherol - from 10 to 50% of petrolatum - from 0.1 to 3% of salicylic acid From 10 to 40% of cyclopentasiloxane - the content of tocopherol acetate in the composition, which is between 50 and 90% by weight, is preferably between 70 and 80% relative to the total weight of the composition. - The petrolatum content in the composition, which is between 10 and 50% by weight, is preferably between 20 and 30% relative to the total weight of the composition. The content of salicylic acid in the composition, which is between 0.1 and 0.3%, is preferably 0.3% relative to the total weight of the composition. The cyclopentasiloxane can be mixed with tocopherol before bringing it into contact with petroleum jelly to form a creamier cream. Its concentration is between 10 and 40%. The composition according to the invention may be presented in the form of a gel, cream, or any other form customary in topical application. Non-limiting exemplary embodiments are given hereinafter to illustrate the invention.

Exemple 1 : Formulation gel Tocophérol acétate 60 % 10 Vaseline 40 % Du poids total de la composition Example 1: Gel formulation Tocopherol acetate 60% Vaseline 40% of the total weight of the composition

Exemple 2 : Autre formulation gel 15 Tocophérol acétate 80 % Vaseline 18,7 % Acide salicylique 0,3 % Du poids total de la composition Example 2: Other formulation gel Tocopherol acetate 80% Vaseline 18.7% Salicylic acid 0.3% of the total weight of the composition

20 Exemple 4 : Formulation crème Tocophérol acétate 50 % Cyclopentasiloxane 40 % Vaseline 10 % 25 Du poids total de la composition Example 4: Cream formulation Tocopherol acetate 50% Cyclopentasiloxane 40% Vaseline 10% Total weight of the composition

Cette composition dermatologique, objet de la présente invention à base de tocophérol acétate et de vaseline, est utilisable en thérapeutique et est présentée sous forme administrable par voie topique et destinée au traitement de pathologies dermatologiques en particulier pour réduire le temps de 30 cicatrisation post traumatique ou chirurgical. -le tocophérol acétate (vitamine E) a des propriétés anti-oxydantes, anti-inflammatoires et hydratantes. Il a un fort pouvoir d'absorption (lors de l'application de tocophérol acétate sur la surface de la peau on retrouve 24 heures après 22% de tocophérol dans le derme). Cela lui confère des propriétés dermatologiques intéressantes en raccourcissant le temps de réparation de différentes 35 formes de dermatoses. 2960777 -3- De plus, par son action antioxydant très puissante, il est à lui seul un conservateur. Il est a l'état pur comestible et a une période de conservation de 12 mois après ouverture sans adjonction de conservateurs pour une concentration minimale de 50% de la composition finale ; La vaseline est couramment utilisée en chirurgie, comme lubrifiant vaginal ou comme additif alimentaire(E 905b). 5 Cela permet au mélange une utilisation réparatrice de sites cutanéo-muqueux sans toxicité. La vaseline est utilisée pour son action dans le traitement d'appoint des lésions d'irritation et de sécheresse cutanée. Elle est aussi utilisée comme lubrifiant des muqueuses vaginales sans toxicité. La vaseline, qui est utilisée en chirurgie en couche épaisse, a pour but de protéger une plaie, de ramollir les sécrétions et d'empêcher la formation de croutes. 10 L'acide salicylique a une action sur l'acné, les verrues et l'hyperhidrose. Son association à la nouvelle composition permettra une action plus importante sur les dermatoses citées précédemment par une action complémentaire de ces trois composés (tocophérol, vaseline et acide salicylique). 2960777 Indication sur les applications industrielles This dermatological composition, object of the present invention based on tocopherol acetate and petrolatum, is therapeutically usable and is presented in topically administrable form and intended for the treatment of dermatological pathologies, in particular for reducing the post-traumatic or post-traumatic healing time. surgical. tocopherol acetate (vitamin E) has antioxidant, anti-inflammatory and moisturizing properties. It has a high absorption capacity (when applying tocopherol acetate on the surface of the skin is found 24 hours after 22% of tocopherol in the dermis). This gives it interesting dermatological properties by shortening the repair time of different forms of dermatoses. 2960777 -3- Moreover, by its very powerful antioxidant action, it is in itself a preservative. It is in the pure edible state and has a shelf life of 12 months after opening without the addition of preservatives for a minimum concentration of 50% of the final composition; Vaseline is commonly used in surgery, as a vaginal lubricant or as a food additive (E 905b). This allows the mixture a repairing use of mucocutaneous sites without toxicity. Vaseline is used for its action in the adjunctive treatment of irritation and dry skin lesions. It is also used as lubricant vaginal mucosa without toxicity. Vaseline, which is used in thick-layer surgery, is intended to protect a wound, soften secretions and prevent the formation of crusts. Salicylic acid has an action on acne, warts and hyperhidrosis. Its combination with the new composition will allow a greater action on the dermatoses mentioned above by a complementary action of these three compounds (tocopherol, petrolatum and salicylic acid). 2960777 Indication on industrial applications

Le tocophérol (vitamine E) a des propriétés anti-oxydantes, anti-inflammatoires et hydratantes. Il a un fort pouvoir d'absorption (lors de l'application d'alpha tocophérol acétate sur la surface de la peau on retrouve 24 heures après 22% de tocophérol dans le derme). Cela lui confère des propriétés dermatologiques intéressantes en raccourcissant le temps de réparation de différentes formes de dermatoses. De plus par son action antioxydant très puissante il est à lui seul un conservateur. Il est a l'état pur est comestible et a une période de conservation de 12 mois après ouverture sans adjonction de conservateurs pour une concentration minimale de 50% de la composition finale. La vaseline est couramment utilisée en chirurgie, comme lubrifiant vaginal, ou comme additif alimentaire(E 905b). Cela permet au mélange une utilisation réparatrice de sites cutanéo-muqueux sans toxicité. La vaseline est utilisée pour son action dans le traitement d'appoint des lésions d'irritation et de sécheresse cutanée. Elle est aussi utilisée comme lubrifiant des muqueuses vaginales sans toxicité. La vaseline, qui est utilisée en chirurgie en couche épaisse, a pour but de protéger une plaie, de ramollir les sécrétions et d'empêcher la formation de croutes. L'acide salicylique a une action sur l'acné, les verrues et l'hyperhidrose. Son association à la nouvelle composition permettra une action plus importante sur les dermatoses citées précédemment par une action complémentaire de ces trois composés (tocophérol, vaseline et acide salicylique). Tocopherol (vitamin E) has anti-oxidant, anti-inflammatory and moisturizing properties. It has a high absorption capacity (when applying alpha tocopheryl acetate on the skin surface is found 24 hours after 22% of tocopherol in the dermis). This gives it interesting dermatological properties by shortening the repair time of different forms of dermatoses. Moreover by its very powerful antioxidant action it is in itself a preservative. It is in its pure state is edible and has a shelf life of 12 months after opening without addition of preservatives for a minimum concentration of 50% of the final composition. Vaseline is commonly used in surgery, as a vaginal lubricant, or as a food additive (E 905b). This allows the mixture a repairing use of mucocutaneous sites without toxicity. Vaseline is used for its action in the adjunctive treatment of irritation and dry skin lesions. It is also used as lubricant vaginal mucosa without toxicity. Vaseline, which is used in thick-layer surgery, is intended to protect a wound, soften secretions and prevent the formation of crusts. Salicylic acid has an action on acne, warts and hyperhidrosis. Its combination with the new composition will allow a greater action on the dermatoses mentioned above by a complementary action of these three compounds (tocopherol, petrolatum and salicylic acid).

Claims (5)

REVENDICATIONS1) Une composition dermatologique caractérisée en ce qu'elle comprend de l'a tocophérol mais également du 13, x ou du S tocophérol ainsi que leur mélanges et leurs dérivés dont le tocophérol acétate, associé a de la vaseline. 1) A dermatological composition characterized in that it comprises a tocopherol but also 13, x or S tocopherol and mixtures thereof and derivatives including tocopherol acetate, associated with petroleum jelly. 2) Une composition dermatologique selon la revendication 1 caractérisée en ce qu'elle comprend en outre de l'acide salicylique. 2) A dermatological composition according to claim 1 characterized in that it further comprises salicylic acid. 3) Une composition dermatologique selon l'une des revendications 1 ou 2 caractérisée en ce qu'elle comprend en outre du cyclopentasiloxane. 3) A dermatological composition according to one of claims 1 or 2 characterized in that it further comprises cyclopentasiloxane. 4) Une composition dermatologique selon l'une des revendications 1 à 3, caractérisée en ce qu'elle renferme pondéralement : De 50 à 90% de tocophérol - De 10 à 50 % de vaseline De 0,1 à 3 % d'acide salicylique - De 10 à 40 % de cyclopentasiloxane 4) A dermatological composition according to one of claims 1 to 3, characterized in that it contains weight: 50 to 90% of tocopherol - 10 to 50% of petrolatum 0.1 to 3% of salicylic acid - 10 to 40% of cyclopentasiloxane 5) Utilisation selon l'une quelconque des revendications précédentes, caractérisé en ce que la composition est administrée sous forme de gel, de crème, ou toute autre forme usuelle en application topique. 5) Use according to any one of the preceding claims, characterized in that the composition is administered in the form of gel, cream, or any other form customary in topical application.
FR1002401A 2010-06-08 2010-06-08 NOVEL DERMATOLOGICAL COMPOSITION COMPRISING BETWEEN TOCOPHEROL AND VASELINE Expired - Fee Related FR2960777B1 (en)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410517A (en) * 1980-05-20 1983-10-18 Theodore Stillman Vitamin E (tocopherol) compositions which resemble petrolatum
US4551332A (en) * 1981-08-05 1985-11-05 Theodore Stillman Vitamin E compositions and methods
US4780145A (en) * 1986-12-23 1988-10-25 Shin-Etsu Chemical Co., Ltd. Gel composition comprising cyclic dimethyl polysiloxanes
RU2160089C1 (en) * 2000-03-14 2000-12-10 Гройсман Валентина Михайловна Skin disease treatment cream
RU2186561C2 (en) * 2000-08-15 2002-08-10 Иорданиди Наталья Николаевна Cream for dry and normal face skin
US20040013784A1 (en) * 2000-03-16 2004-01-22 Fortunato Costa Additive method of standardized drinks and potable water production
UA65846A (en) * 2003-06-10 2004-04-15 Alpina Yakivna Tolok Antiseptic, anti-inflammatory, and wound-healing ointment
CN101313885A (en) * 2008-07-08 2008-12-03 重庆五环富侨保健有限公司 Foot treating massage paste

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410517A (en) * 1980-05-20 1983-10-18 Theodore Stillman Vitamin E (tocopherol) compositions which resemble petrolatum
US4551332A (en) * 1981-08-05 1985-11-05 Theodore Stillman Vitamin E compositions and methods
US4780145A (en) * 1986-12-23 1988-10-25 Shin-Etsu Chemical Co., Ltd. Gel composition comprising cyclic dimethyl polysiloxanes
RU2160089C1 (en) * 2000-03-14 2000-12-10 Гройсман Валентина Михайловна Skin disease treatment cream
US20040013784A1 (en) * 2000-03-16 2004-01-22 Fortunato Costa Additive method of standardized drinks and potable water production
RU2186561C2 (en) * 2000-08-15 2002-08-10 Иорданиди Наталья Николаевна Cream for dry and normal face skin
UA65846A (en) * 2003-06-10 2004-04-15 Alpina Yakivna Tolok Antiseptic, anti-inflammatory, and wound-healing ointment
CN101313885A (en) * 2008-07-08 2008-12-03 重庆五环富侨保健有限公司 Foot treating massage paste

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